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High Fidelity Virtual Stenting (HiFiVS) for Intracranial Aneurysm Flow Diversion: In Vitro and In Silico

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Abstract

A flow diverter (FD) is a flexible, densely braided stent-mesh device placed endoluminally across an intracranial aneurysm to induce its thrombotic occlusion. FD treatment planning using computational virtual stenting and flow simulation requires accurate representation of the expanded FD geometry. We have recently developed a high fidelity virtual stenting (HiFiVS) technique based on finite element analysis to simulate detailed FD deployment processes in patient-specific aneurysms (Ma et al. J. Biomech. 45:2256–2263, 2012). This study tests if HiFiVS simulation can recapitulate real-life FD implantation. We deployed two identical FDs (Pipeline Embolization Device) into phantoms of a wide-necked segmental aneurysm using a clinical push–pull technique with different delivery wire advancements. We then simulated these deployment processes using HiFiVS and compared results against experimental recording. Stepwise comparison shows that the simulations precisely reproduced the FD deployment processes recorded in vitro. The local metal coverage rate and pore density quantifications demonstrated that simulations reproduced detailed FD mesh geometry. These results provide validation of the HiFiVS technique, highlighting its unique capability of accurately representing stent intervention in silico.

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Acknowledgments

This study was partially supported by NIH/NINDS (Grant No. R01NS064592), Toshiba Medical Systems, Covidien (Grant No. VTGCC053012-009), and National Science Foundation of China (Grant No. 81220108007 and 81171079). We thank Dr. Jianping Xiang for assistance in phantom fabrication, Dr. Robert Baier for surface analysis of FD strands, Lisa Pope and Michael Rejewski for assistance on in vitro experiment, and Nicholas Liaw for editorial assistance.

Conflict of interest

The authors Ma, Dumont, Kosukegawa, Ohta, and Yang have no conflict of interest. Meng—Principal investigator of NIH/NINDS Grant R01NS064592. Siddiqui—Research Grants–NIH (co-investigator: NINDS 1R01NS064592-01A1), University at Buffalo (Research Development Award); financial interests–Hotspur, Intratech Medical, StimSox, Valor Medical; consultant to Codman & Shurtleff, Concentric Medical, ev3/Covidien Vascular Therapies, GuidePoint Global Consulting, Penumbra; speakers’ bureaus—Codman & Shurtleff, Genentech; advisory board–Codman & Shurtleff; honoraria–Abbott Vascular, Codman & Shurtleff, Genentech, Neocure Group LLC.

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Authors and Affiliations

  1. Toshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, 875 Ellicott Street, Buffalo, NY, 14203, USA

    Ding Ma, Travis M. Dumont, Adnan H. Siddiqui & Hui Meng

  2. Department of Mechanical and Aerospace Engineering, University at Buffalo, State University of New York, Buffalo, NY, USA

    Ding Ma & Hui Meng

  3. Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, NY, USA

    Travis M. Dumont, Adnan H. Siddiqui & Hui Meng

  4. Department of Radiology, University at Buffalo, State University of New York, Buffalo, NY, USA

    Adnan H. Siddiqui

  5. Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, USA

    Hui Meng

  6. Institute of Fluid Science, Tohoku University, Sendai, Japan

    Hiroyuki Kosukegawa & Makoto Ohta

  7. Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Xinjian Yang

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  1. Ding Ma
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  2. Travis M. Dumont
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  6. Adnan H. Siddiqui
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  7. Hui Meng
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Correspondence to Hui Meng.

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Associate Editor Jane Grande-Allen oversaw the review of this article.

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Ma, D., Dumont, T.M., Kosukegawa, H. et al. High Fidelity Virtual Stenting (HiFiVS) for Intracranial Aneurysm Flow Diversion: In Vitro and In Silico . Ann Biomed Eng 41, 2143–2156 (2013). https://doi.org/10.1007/s10439-013-0808-4

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  • DOI: https://doi.org/10.1007/s10439-013-0808-4

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