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Magnetic Nanoparticle Targeted Hyperthermia of Cutaneous Staphylococcus aureus Infection

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An Erratum to this article was published on 04 December 2012

Abstract

The incidence of wound infections that do not adequately respond to standard-of-care antimicrobial treatment has been increasing. To address this challenge, a novel antimicrobial magnetic thermotherapy platform has been developed in which a high-amplitude, high-frequency, alternating magnetic field is used to rapidly heat magnetic nanoparticles that are bound to Staphylococcus aureus (S. aureus). The antimicrobial efficacy of this platform was evaluated in the treatment of both an in vitro culture model of S. aureus biofilm and a mouse model of cutaneous S. aureus infection. We demonstrated that an antibody-targeted magnetic nanoparticle bound to S. aureus was effective at thermally inactivating S. aureus and achieving accelerated wound healing without causing tissue injury.

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Acknowledgments

We thank Dr. Thomas Graf (Center for Genomic Regulation, Barcelona Spain) and Dr. Ambros Cheung (Dartmouth Medical School) for generously providing EGFP-lys-mice and the bioluminescent strain of S. aureus. We also thank Dr. Jose Renau (UC Santa Cruz) for use of the FLIR SC8000 thermal camera. This research was supported by NIH AI47294 and a generous grant from the Robert S. and Star Pepper Foundation to SIS, as well as other private donors.

Conflict of interests

Joseph Nayfech (Qteris, Inc.) declares competing financial interest.

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of California at Davis, 451 E. Health Sciences Dr., Davis, CA, 95616, USA

    Min-Ho Kim, Itsukyo Yamayoshi, Steven Mathew, Hubert Lin & Scott I. Simon

  2. College of Applied Engineering, Sustainability, and Technology, Kent State University, Kent, OH, 44242, USA

    Min-Ho Kim

  3. Qteris, Inc., San Rafael, CA, 94903, USA

    Joseph Nayfach

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  1. Min-Ho Kim
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  2. Itsukyo Yamayoshi
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Correspondence to Scott I. Simon.

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Associate Editor Sriram Neelamegham oversaw the review of this article.

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Kim, MH., Yamayoshi, I., Mathew, S. et al. Magnetic Nanoparticle Targeted Hyperthermia of Cutaneous Staphylococcus aureus Infection. Ann Biomed Eng 41, 598–609 (2013). https://doi.org/10.1007/s10439-012-0698-x

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  • DOI: https://doi.org/10.1007/s10439-012-0698-x

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