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Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

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Abstract

Advances in microengineering technologies have enabled a variety of insights into biomedical sciences that would not have been possible with conventional techniques. Engineering microenvironments that simulate in vivo organ systems may provide critical insight into the cellular basis for pathophysiologies, development, and homeostasis in various organs, while curtailing the high experimental costs and complexities associated with in vivo studies. In this article, we aim to survey recent attempts to extend tissue-engineered platforms toward simulating organ structure and function, and discuss the various approaches and technologies utilized in these systems. We specifically focus on microtechnologies that exploit phenomena associated with compartmentalization to create model culture systems that better represent the in vivo organ microenvironment.

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA

    Christopher Moraes, Geeta Mehta, Sasha Cai Lesher-Perez & Shuichi Takayama

  2. Department of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, 48109, USA

    Shuichi Takayama

  3. Division of Nano-Bio and Chemical Engineering WCU Project, UNIST, Ulsan, Republic of Korea

    Shuichi Takayama

Authors
  1. Christopher Moraes
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  2. Geeta Mehta
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  3. Sasha Cai Lesher-Perez
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  4. Shuichi Takayama
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Correspondence to Shuichi Takayama.

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Associate Editor Michael Shuler oversaw the review of this article.

The first three authors contributed equally in this study.

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Moraes, C., Mehta, G., Lesher-Perez, S.C. et al. Organs-on-a-Chip: A Focus on Compartmentalized Microdevices. Ann Biomed Eng 40, 1211–1227 (2012). https://doi.org/10.1007/s10439-011-0455-6

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  • DOI: https://doi.org/10.1007/s10439-011-0455-6

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