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Hemodynamic Analysis of Microcirculation in Malaria Infection

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Abstract

Malaria-infected red blood cells (IRBCs) show various changes in mechanical properties. IRBCs lose their deformability and develop properties of cytoadherence and rosetting. To clarify how these changes advance microvascular occlusion, we need qualitative and quantitative information on hemodynamics in malaria infection, including the interaction among IRBCs, healthy RBCs, and endothelial cells. We developed a numerical model of blood flow with IRBCs based on conservation laws of fluid dynamics. The deformability and adhesive property of IRBCs were simply modeled using springs governed by Hook’s law. Our model could express the basic behavior of IRBCs, including the rolling motion due to cytoadhesive interaction with endothelial cells and complex interaction with healthy RBCs. We confirmed that these types of interactions significantly increase the flow resistance, particularly when knobs develop.

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Acknowledgments

This study was made possible by the following grants: the “Revolutionary Simulation Software (RSS21)” project, supported by the next-generation IT program of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Grants-in-Aid for Scientific Research from MEXT, and JSPS Scientific Research in Priority Areas (768) “Biomechanics at Micro- and Nano-scale Levels” and Scientific Research(A) No.16200031 “Mechanism of the Formation, Destruction, and Movement of Thrombi Responsible for Ischemia of Vital Organs”.

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Authors and Affiliations

  1. Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki Aza Aoba, Sendai, 980-8579, Japan

    Hitoshi Kondo, Yohsuke Imai & Takuji Ishikawa

  2. Department of Mechanical Engineering, Division of Artificial System Science, Graduate School of Engineering, Chiba University, 1-33 Yayoi, Inage, Chiba, 263-8522, Japan

    Ken-ichi Tsubota

  3. Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 6-6-01 Aramaki Aza Aoba, Sendai, 980-8579, Japan

    Takami Yamaguchi

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  1. Hitoshi Kondo
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  2. Yohsuke Imai
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  3. Takuji Ishikawa
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  4. Ken-ichi Tsubota
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  5. Takami Yamaguchi
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Correspondence to Yohsuke Imai.

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Kondo, H., Imai, Y., Ishikawa, T. et al. Hemodynamic Analysis of Microcirculation in Malaria Infection. Ann Biomed Eng 37, 702–709 (2009). https://doi.org/10.1007/s10439-009-9641-1

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  • DOI: https://doi.org/10.1007/s10439-009-9641-1

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