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Influence of the Opening Mode of the Mitral Valve Orifice on Intraventricular Hemodynamics

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Abstract

We analyzed intraventricular blood flow numerically to study the influence of the mode of mitral valve opening on the flow field in the left ventricle. Four different types of opening mode were examined: gradually axisymmetric, gradually anteroposterior (anatomical), gradually bilateral (anti-anatomical), or instantaneous opening and closing. In these models, the shape of the valve orifice was the same when the mitral valve was opened fully. The results demonstrated that the framework of the velocity profile of transmitral flow was built during the phase of mitral valve opening, which was characterized by the mode of valve opening. After the mitral valve opened completely, the transmitral velocity profile developed while maintaining its topological features. Consequently, each mode of mitral valve opening had its own pattern of intraventricular flow, although mitral valve opening accounted for less than 4% of a cardiac cycle. Particle tracking in the resulting flow field revealed that ventricular ejection was more efficient in the anteroposterior and axisymmetric opening modes. These results addressed the importance of the mode of mitral valve opening in intraventricular flow dynamics.

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ACKNOWLEDGMENTS

This work was supported by a Research Fellowship from the Japan Society for the Promotion of Science for Young Scientists (No. 06787). It was also funded by Grants-in-Aid of Scientific Research No. 15086204 and 17300138, the “Revolutionary Simulation Software (RSS21)” project, supported by the next-generation IT program of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Grants-in-Aid of Scientific Research from the MEXT and JSPS Scientific Research in Priority Areas (768) “Biomechanics at Micro- and Nanoscale Levels,” and Scientific Research (A) No.16200031, “Mechanism of the formation, destruction, and movement of thrombi responsible for ischemia of vital organs.”

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Authors and Affiliations

  1. Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, Aoba 6-6-01, Sendai, Japan

    Masanori Nakamura, Shigeo Wada & Takami Yamaguchi

  2. Physiological Flow Studies Laboratory, Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, Aoba 6-6-01, Sendai, 980-8579, Japan

    Masanori Nakamura

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  1. Masanori Nakamura
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Correspondence to Masanori Nakamura.

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Nakamura, M., Wada, S. & Yamaguchi, T. Influence of the Opening Mode of the Mitral Valve Orifice on Intraventricular Hemodynamics. Ann Biomed Eng 34, 927–935 (2006). https://doi.org/10.1007/s10439-006-9127-3

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  • DOI: https://doi.org/10.1007/s10439-006-9127-3

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