Skip to main content
SpringerLink
Log in

Calcium as a Regulator of Intracellular Processes in Actinomycetes: A Review

  • Published:
Applied Biochemistry and Microbiology Aims and scope Submit manuscript

Abstract

Data on the effects of calcium ions (Ca2+) on processes of morphological and physiological differentiation in cultures of actinomycetes have been reviewed, with emphasis on representatives of the genus Strepomyces. Evidence accumulated thus far regarding the regulatory role of serine-threonine protein kinases in the differentiation and the possible involvement of Ca2+-dependent protein kinases in secondary metabolism (including antibiotic biosynthesis) are analyzed. The possibility that regulatory elements of apoptosis (including Ca2+-dependent) function in actinomycetes is discussed. A hypothesis is advanced, according to which determinants of antibiotic resistance play a key role in the network of signal transduction systems of actinomycetes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

APT:

aminoglycoside phosphotransferase

CM:

calmodulin

CML:

chloramphenicol

EGTA:

ethylene glycol tetraacetate (Ca2+ chelator)

LIE:

leupeptin-inactivating enzyme

MDTR:

multiple drug resistance transcription regulator

STPK:

serine-threonine protein kinase

STS:

signal transduction system

TLP:

trypsin-like protease

REFERENCES

  1. Chater, K.F., Microbiology, 1998, vol. 144, no.4, pp. 1465–1478.

    Google Scholar 

  2. Berridge, M.J., Biochem. Soc. Trans., 2003, vol. 31, no.5, pp. 930–933.

    Google Scholar 

  3. Crivici, A. and Ikura, M., Annu. Rev. Biophys. Biomol. Struct., 1995, vol. 24, pp. 85–116.

    Google Scholar 

  4. Stabel, S. and Parker, P.J., Pharmacol. Ther., 1991, vol. 51, no.1, pp. 71–95.

    Google Scholar 

  5. Mellor, H. and Parker, P.J., Biochem. J., 1998, vol. 332, no.2, pp. 281–292.

    Google Scholar 

  6. Oancea, E. and Meyer, T., Cell, 1998, vol. 95, no.3, pp. 307–318.

    Google Scholar 

  7. Norris, V., Grant, S., and Freestone, P., J. Bacteriol., 1996, vol. 178, no.13, pp. 3677–3682.

    Google Scholar 

  8. Werthen, M. and Lundgren, T., J. Biol. Chem., 2001, vol. 276, no.9, pp. 6468–6472.

    Google Scholar 

  9. Jones, H.E., Holland, I.B., Baker, H.L., and Campbell, A.K., Cell Calcium, 1999, vol. 25, no.3, pp. 265–274.

    Google Scholar 

  10. Levy, J., Bres, C., Geurts, R., Chalhoub, B., Kulikova, O., Duc, G., Journet, E.P., Ane, J.M., Lauber, E., Bisseling, T., Denarie, J., Rosenberg, C., and Debelle, F., Science, 2004, vol. 303, no.5662, pp. 1361–1364.

    Google Scholar 

  11. Smith, R.J., Adv. Microb. Physiol., 1995, vol. 37, pp. 83–133.

    Google Scholar 

  12. Natsume, M., Yasui, K., and Marumo, S., J. Antibiot., 1989, vol. 42, no.13, pp. 440–447.

    Google Scholar 

  13. Natsume, M., J. Antibiotics, 1992, vol. 45, no.6, pp. 1026–1028.

    Google Scholar 

  14. Natsume, M., Tazava, J., and Abe, H., Biosci. Biotechnol. Biochem., 1995, vol. 59, no.1, pp. 152–154.

    Google Scholar 

  15. Natsume, M., Actinomycetol., 1999, vol. 13, no.1, pp. 11–19.

    Google Scholar 

  16. Penyige, A., Kelemen, G.H., and Barabas, G., Proc. 13th Int. Symp. Biol. Actinomycetes, Melbourne, 2004, pp. 23–24.

  17. Tussavainen, H., Permi, P., and Annila, A., Eur. J. Bio-chem., 2003, vol. 270, no.6, pp. 2505–2512.

    Google Scholar 

  18. Yonerava, T., Ohnishi, Y., and Horinouchi, S., Boisci. Biotechnol. Biochem., 2001, vol. 65, no.1, pp. 156–160.

    Google Scholar 

  19. Ivanova, I.V., Khristova, A.R., Danova, S.T., and Moncheva, P.A., Antibiot. Khimioter., 1994, vol. 39, no.11, pp. 21–27.

    Google Scholar 

  20. Danova, S.T., Moncheva, P.A., Antonova, S.K., and Ivanova, I.V., Antibiot. Khimioter., 1997, vol. 42, no.4, pp. 12–15.

    Google Scholar 

  21. Wais, R.J., Galera, C., Oldroyd, G., Catoira, R., Penmetsa, R.V., Cook, D., Gough, C., Denarie, J., and Long, S.R., Proc. Natl. Acad. Sci. USA, 2000, vol. 97, no.24, pp. 13407–13412.

    Google Scholar 

  22. Gregor, A.K., Klubek, B., and Varsa, E.C., Can. J. Microbiol., 2003, vol. 49, no.8, pp. 483–491.

    Google Scholar 

  23. Hellingwerf, K.J., Postma, P.W., Tommassen, J., and Westerhoff, H.V., FEMS Microbiol. Rev., 1995, vol. 16, no.4, pp. 309–321.

    Google Scholar 

  24. Munoz-Dorado, J., Inouye, S., and Inouye, M., Cell, 1991, vol. 67, no.5, pp. 995–1006.

    Google Scholar 

  25. Petrickova, K. and Petricek, M., Microbiology, 2003, vol. 149, no.4, pp. 1609–1621.

    Google Scholar 

  26. Horinouchi, S. and Beppu, T., Gene, 1992, vol. 115, nos.1–2, pp. 167–172.

    Google Scholar 

  27. Lee, P.-C., Umeyama, T., and Horinouchi, S., Mol. Microbiol., 2002, vol. 43, no.6, pp. 1413–1430.

    Google Scholar 

  28. O’Connor, T.J., Kanellis, P., and Nodwell, J.R., Mol. Microbiol., 2002, vol. 45, no.1, pp. 45–57.

    Google Scholar 

  29. Nadvornik, R., Vomastek, T., Janecek, J., Technikova, Z., and Branny, P., J. Bacteriol., 1999, vol. 181, no.1, pp. 15–23.

    Google Scholar 

  30. Neu, J.M., MacMillan S.V., Nodwell J.R., Wright G.D, Mol. Microbiol., 2002, vol. 44, no.2, pp. 417–430.

    Google Scholar 

  31. Ueda, K., Umeyama, T., Beppu, T., and Horinouchi, S., Gene, 1996, vol. 169, no.1, pp. 91–95.

    Google Scholar 

  32. Elizarov, S.M., Mironov, V.A., and Danilenko, V.N., IUBMB Life, 2000, vol. 50, no.1, pp. 1–5.

    Google Scholar 

  33. Elizarov, S.M. and Danilenko, V.N., FEMS Microbiol. Letts., 2001, vol. 202, pp. 135–138.

    Google Scholar 

  34. Oancea, E. and Meyer, T., Cell, 1998, vol. 95, no.3, pp. 307–18.

    Google Scholar 

  35. Thomas, A.P., Bird, G.S., Hajnoczky, G., Robb-Gaspers, L.D., and Putney, J.W., FASEB J., 1996, vol. 10, no.13, pp. 1505–1517.

    Google Scholar 

  36. Elizarov, S.M., Mironov, V.A., and Danilenko, V.N., Prikl. Biokhimiya Mikrobiologiya, 1999, vol. 35, no.6, pp. 647–653.

    Google Scholar 

  37. Elizarov, S.M., Mironov, V.A., and Danilenko, V.N., Mikrobiologiya, 2000, vol. 69, no.3, pp. 345–351.

    Google Scholar 

  38. Elizarov, S.M., Gavrilina, A.V., and Danilenko, V.N., Mol. Biol., 2004, vol. 38, no.3, pp. 1–10.

    Google Scholar 

  39. Elizarov, S.M., Sergienko, O.V., Sizova, I.A., and Danilenko, V.N., Mol. Biol., 2005, vol. 39, no.2, pp. 1–9.

    Google Scholar 

  40. Mironov, V.A., Antonova, S.V., Bobyleva, R.I., and Danilenko, V.N., Antibiot. Khimoter., 1997, vol. 42, no.4, pp. 3–7.

    Google Scholar 

  41. Elizarov, S.M., Michurina, T.A., and Danilenko, V.N., Antibiot. Khimioter., 1998, vol. 43, no.2, pp. 3–8.

    Google Scholar 

  42. Hensel, M., Deckers-Hebestreit, G., and Altendorf, K., Eur. J. Biochem., 2002, vol. 18, no.202, pp. 1313–1319.

    Google Scholar 

  43. Reeves, A.R., Weber, G., Cernota, W.H., and Weber, J.M., Antimicrob. Agents Chemother., 2002, vol. 46, no.12, pp. 3892–3899.

    Google Scholar 

  44. Berdy, J., Proc. 9th Int. Symp. Biol. Actinomycetes, Moscow, 1996, vol. 7–8, pp. 13–37.

    Google Scholar 

  45. Demain, A.L. and Fang, A., Adv. Biochem. Eng. Biotechnol., 2000, vol. 69, pp. 1–39.

    Google Scholar 

  46. Danilenko, V.N., Puzynina, T.G., and Lomovskaya, N.D., Genetika, 1977, vol. 13, no.10, pp. 1831–1842.

    Google Scholar 

  47. Danilenko, V.N. and Akopiants, K.E., Proc. 9th Int. Symp. Biol. Actinomycetes, Moscow, 1996, vol. 7–8, pp. 104–112.

    Google Scholar 

  48. Akopyants, K.E., Sizova, I.A., Michurina, T.A., and Danilenko, V.N., Antibiot. Khimioter., 1997, vol. 42, no.9, pp. 3–13.

    Google Scholar 

  49. Sizova, I.A., Khegemann, P., Furman, M., and Danilenko, V.N., Mol. Biol., 2002, vol. 36, no.1, pp. 18–25.

    Google Scholar 

  50. RF Patent 147320, Byull. Izobret., 2000.

  51. RF Patent 147319, Byull. Izobret., 2000.

  52. Danilenko, V.N., Elizarov, S.M., Sizova, I.A., and Alekseeva, M.G., Mat. WCDA, Nurnberg, Germany, 2004, p. A29.

  53. Kahmann, J.D., Sass, H.J., Allan, M.G., Seto, H., Thompson, C.J., and Grzesiek, S., EMBO J., 2003, vol. 22, no.8, pp. 1824–1834.

    Google Scholar 

  54. Barrett, J.F., Goldschmidt, R.M., Lawrence, L.E., Foleno, B., and Chen, R., Proc. Natl. Acad. Sci. USA, 1998, vol. 95, no.9, pp. 5317–5322.

    Google Scholar 

  55. Miguelez, E.M., Int. Microbiol., 2000, vol. 3, no.2, pp. 153–158.

    Google Scholar 

  56. Aravind, L., Dixit, V.M., and Koonin, E.V., Trends Biochem. Sci., 1999, vol. 24, no.1, pp. 47–53.

    Google Scholar 

  57. Miguelez, E.M., Hardisson, C., and Manzanal, M.B., J. Cell Biol., 1999, vol. 145, no.3, pp. 515–525.

    Google Scholar 

  58. Nicieza, R.G., Huergo, J., Connolly, A., and Sanchez, J., J. Biol. Chem., 1999, vol. 274, no.29, pp. 20366–20375.

    Google Scholar 

  59. Montague, J.W., Gaido, M.L., Frye, C., and Cidlowski, J.A., J. Biol. Chem., 1994, vol. 269, no.29, pp. 18877–18880.

    Google Scholar 

  60. Fernandez, M. and Sanchez, J., Microbology, 2002, vol. 148, no.2, pp. 405–412.

    Google Scholar 

  61. Kutsyi, M.P., Kuznetsova, E.A., and Gaziev, A.I., Biokhimiya, 1999, vol. 64, no.2, pp. 149–163.

    Google Scholar 

  62. Ginther, C.L., Antimicrob. Agents Chemother., 1979, vol. 15, no.4, pp. 522–526.

    Google Scholar 

  63. Gibb, G.D. and Strohl, W.R., Can. J. Microbiol., 1988, vol. 34, no.2, pp. 187–190.

    Google Scholar 

  64. Bascaran, V., Hardisson, C., and Brana, A.F., FEMS Microbiol. Lett., 1990, vol. 57, nos.1–2, pp. 27–30.

    Google Scholar 

  65. Kim, I.S. and Lee, K.J., Microbiology, 1995, vol. 141, no.4, pp. 1017–1025.

    Google Scholar 

  66. Kim, I.S. and Lee, K.J., Microbiology, 1996, vol. 142, no.7, pp. 1797–1806.

    Google Scholar 

  67. Moncheva, P.A., Danova, S.T., Antonova, S.K., and Ivanova, I.V., Antibiot. Khimioter., 1997, vol. 42, no.9, pp. 14–19.

    Google Scholar 

  68. Mendez, C., Brana, A.F., Manzanal, M.B., and Hardisson, C., Can. J. Microbiol., 1985, vol. 31, no.5, pp. 446–450.

    Google Scholar 

  69. Miguelez, E.M., Garcia, M., Hardisson, C., and Manzanal, M.B., J. Bacteriol., 1994, vol. 176, no.7, pp. 2105–2107.

    Google Scholar 

  70. Prokof’eva-Bel’govskaya, A., Stroenie i razvitie aktinomitsetov (Structure and Development of Actinomycetes), Moscow: Akad. Nauk SSSR, 1963.

    Google Scholar 

  71. Chater, K.F. and Horinouchi, S., Mol. Microbiol., 2003, vol. 48, no.1, pp. 9–15.

    Google Scholar 

  72. Coleman, R.N. and Ensign, J.C., J. Bacteriol., 1982, vol. 149, no.3, pp. 1102–1111.

    Google Scholar 

  73. Daza, A., Martin, J.F., Dominguez, A., and Gil, J.A., J. Gen. Microbiol., 1989, vol. 135, no.9, pp. 2483–2491.

    Google Scholar 

  74. Martin, J.F. and Demain, A.L., Microbiol. Rev., 1980, vol. 44, no.2, pp. 230–251.

    Google Scholar 

  75. Sola-Landa, A., Moura, R.S., and Martin, J.F., Proc. Natl. Acad. Sci. U.S.A., 2003, vol. 100, no.10, pp. 6133–6138.

    Google Scholar 

  76. She, Y., Cell. Press. Molecular., 2002, vol. 9, no.3, pp. 459–470.

    Google Scholar 

  77. McConkey, D.J. and Orrenius, S., Biochem. Biophys. Res. Commun., 1997, vol. 239, no.2, pp. 357–366.

    Google Scholar 

  78. Mizuta, K., Hashimoto, E., and Yamamura, H., Biochem. Biophys. Res. Commun., 1985, vol. 131, no.3, pp. 1262–1268.

    Google Scholar 

  79. Richert, N.D. and Ryan, R.J., Proc. Natl. Acad. Sci. USA, 1977, vol. 74, no.11, pp. 4857–4861.

    Google Scholar 

  80. Floriano, B. and Bibb, M., Mol. Microbiol., 1996, vol. 21, no.2, pp. 385–396.

    Google Scholar 

  81. Kim, E.S., Hong, H.J., Choi, C.Y., and Cohen, S.N., J. Bacteriol., 2001, vol. 183, no.7, pp. 2198–2203.

    Google Scholar 

  82. Anderson, P., Microbiol. Mol. Biol. Rev., 1997, vol. 61, no.1, pp. 33–46.

    Google Scholar 

  83. Koch, A.L., J. Theor. Biol., 1994, vol. 171, no.2, pp. 137–150.

    Google Scholar 

  84. Heydarian, S.M., Mirjalili, N., and Ison, A.P., Bioproces. Eng., 1999, vol. 21, no.1, pp. 31–39.

    Google Scholar 

  85. Stocks, S.M. and Thomas, C.R., Biotechnol. Bioeng., 2001, vol. 73, no.5, pp. 370–378.

    Google Scholar 

  86. Stocks, S.M. and Thomas, C.R., Biotechnol. Bioeng., 2001, vol. 75, no.6, pp. 702–709.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. State Research Institute of Biosynthesis of Proteinaceous Compounds, Moscow, 109004, Russia

    V. N. Danilenko & V. A. Mironov

  2. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071, Russia

    S. M. Elizarov

Authors
  1. V. N. Danilenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. A. Mironov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. M. Elizarov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Prikladnaya Biokhimiya i Mikrobiologiya, Vol. 41, No. 4, 2005, pp. 363–375.

Original Russian Text Copyright © 2005 by Danilenko, Mironov, Elizarov.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Danilenko, V.N., Mironov, V.A. & Elizarov, S.M. Calcium as a Regulator of Intracellular Processes in Actinomycetes: A Review. Appl Biochem Microbiol 41, 319–329 (2005). https://doi.org/10.1007/s10438-005-0055-z

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10438-005-0055-z

Keywords

Search

Navigation