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Preoperative Combined Radiotherapy and Chemotherapy for Middle and Lower Rectal Cancer: Preliminary Results

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Abstract

Background: Adjuvant treatment for rectal cancer is still controversial. This study reports on overall survival and disease-free survival, toxicity, downstaging, and surgical morbidity in rectal cancer patients who received combined chemoradiation therapy followed by curative surgery.

Methods: Between 1993 and 1998, 51 patients (31 males and 20 females; median age, 60 years; range, 33–73 years) underwent chemoradiation therapy followed by radical surgery for middle and lower rectal adenocarcinoma. Criteria for giving preoperative radiotherapy (total 45 Gy in 25 fractions of 1.8 Gy/day for 5 weeks) and chemotherapy (5-fluorouracil 350 mg/m2/day and leucovorin 10 mg/m2/day, bolus on days 1–5 and 29–33) were an age younger than 75 years; an Eastern Cooperative Oncology Group performance status score of 0 to 2; and clinical preoperative stage II–III. Forty-three low anterior and eight abdominoperineal resections were performed. Median follow-up time was 29 (range, 3–63) months.

Results: Although grade 3 to 4 toxicity occurred in 14 cases (27.4%), all patients completed the planned adjuvant therapy. At pathology, a complete response was found in eight (15.7%) cases. Of the remaining 43 cases, 22 were stage I, 12 were stage II, and 9 were stage III. Five-year actuarial disease-free survival and overall survival rates were 86.4% and 85.5%, respectively. Whereas no local recurrences were found, 4 patients had distant metastases. Three patients died (1 of cancerrelated causes), 45 are alive and disease free, and 3 are alive with disease.

Conclusions: The combined preoperative chemoradiation approach used by us seems to improve the disease-free survival and overall survival of selected patients with rectal cancer. However, a longer follow-up time is required to confirm these preliminary results.

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Authors and Affiliations

  1. Clinica Chirurgica II, Dipartimento di Scienze Oncologiche e Chirurgiche, Università di Padova, Azienda Ospedaliera di Padova, Padova, Italy

    Salvatore Pucciarelli MD, Paola Toppan MD, Sandro Carnio MD, Elisabetta Marchiori MD & Mario Lise MD

  2. Divisione di Radioterapia, Azienda Ospedaliera di Padova, Padova, Italy

    Maria Luisa Friso MD

  3. Divisione di Oncologia Medica, Azienda Ospedaliera di Padova, Padova, Italy

    Adriano Fornasiero MD

  4. Dipartimento di Scienze Oncologiche e Chirurgiche, Sezione di Clinica Chirurgica II, Policlinico, VI Piano, Via Giustiniani 2, 35100, Padova, Italy

    Salvatore Pucciarelli MD

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  1. Salvatore Pucciarelli MD
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  2. Maria Luisa Friso MD
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  3. Paola Toppan MD
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  4. Adriano Fornasiero MD
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  5. Sandro Carnio MD
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  6. Elisabetta Marchiori MD
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  7. Mario Lise MD
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Presented at the 52nd Annual Meeting of Society of Surgical Oncology, Orlando, Florida, March 4–7, 1999.

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Pucciarelli, S., Friso, M.L., Toppan, P. et al. Preoperative Combined Radiotherapy and Chemotherapy for Middle and Lower Rectal Cancer: Preliminary Results. Ann Surg Oncol 7, 38–44 (2000). https://doi.org/10.1007/s10434-000-0038-5

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  • DOI: https://doi.org/10.1007/s10434-000-0038-5

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