Skip to main content
Log in

Self-optimizing, thermally adaptive microfluidic flow structures

  • Research Paper
  • Published:
Microfluidics and Nanofluidics Aims and scope Submit manuscript

Abstract

Although microfluidic devices offer many benefits, high fluid shear stresses in such devices are an undesirable consequence of miniaturization. In the present study, we present an adaptive “smart” design that mitigates the effects of high shear stresses in microfluidic-based devices by autonomously optimizing its internal flow structure. This concept was demonstrated by testing a prototype microscale thermal-fluid device that responded to changes in the local thermal environment. The autonomous, self-optimizing functionality was achieved using poly(N-isopropylacrylamide) hydrogel actuated microvalves, which independently controlled the flow to four distinct regions within the device. The experimental results showed that the device optimized its internal topological flow arrangement such that fluid was delivered only to regions where cooling was required. As a result, a series of spatially distributed thermal loads were dissipated with minimal pumping power consumption.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  • Baldi A, Yuandong G, Loftness PE, Siegel RA, Ziaie B (2003) A hydrogel-actuated environmentally sensitive microvalve for active flow control. J Microelectromech Syst 12(5):613–621

    Article  Google Scholar 

  • Beebe DJ, Moore JS, Bauer JM, Yu Q, Liu RH, Devadoss C, Jo BH (2000) Functional hydrogel structures for autonomous flow control inside microfluidic channels. Nature 404(6778):588–590

    Article  Google Scholar 

  • Bejan A (2000) Shape and structure, from engineering to nature. Cambridge University Press, Cambridge

    MATH  Google Scholar 

  • Bejan A, Errera MR (2000) Convective trees of fluid channels for volumetric cooling. Int J Heat Mass Transfer 43(17):3105–3118

    Article  MATH  Google Scholar 

  • Cao X, Lai S, Lee LJ (2001) Design of a self-regulated drug delivery device. Biomed Microdevices 3(2):109–118

    Article  Google Scholar 

  • Champagne PR, Bergles AE (2001) Development and testing of a novel, variable-roughness technique to enhance, on demand, heat transfer in a single-phase heat exchanger. J Enhanc Heat Transf 8(5):341–352

    Google Scholar 

  • Coleman HW, Steele WG (1999) Experimentation and uncertainty analysis for engineers, 2nd edn. Wiley, New York

    Google Scholar 

  • Dong L, Jiang H (2007) Autonomous microfluidics with stimuli-responsive hydrogels. Soft Matter 3(10):1223–1230

    Article  Google Scholar 

  • Eddington DT, Liu RH, Moore JS, Beebe DJ (2001) An organic self-regulating microfluidic system. Lab Chip 1(2):96–99

    Article  Google Scholar 

  • Garimella SV (2006) Advances in mesoscale thermal management technologies for microelectronics. Microelectron J 37(11):1165–1185

    Article  Google Scholar 

  • Gerlach G, Arndt KF (2009) Hydrogel sensors and actuators. Springer, New York

    Google Scholar 

  • Harmon ME, Tang M, Frank CW (2003) A microfluidic actuator based on thermoresponsive hydrogels. Polymer 44(16):4547–4556

    Article  Google Scholar 

  • Hart RA, da Silva AK (2011) Experimental thermal–hydraulic evaluation of constructal microfluidic structures under fully constrained conditions. Int J Heat Mass Transfer 54(15–16):3661–3671

    Article  Google Scholar 

  • Hart RA, Ponkala MJV, da Silva AK (2011) Development and testing of a constructal microchannel flow system with dynamically controlled complexity. Int J Heat Mass Transfer 54(25–26):5470–5480

    Article  Google Scholar 

  • Hoffmann J, Plötner M, Kuckling D, Fischer W-J (1999) Photopatterning of thermally sensitive hydrogels useful for microactuators. Sens Actuators A 77(2):139–144

    Article  Google Scholar 

  • Kellogg DL (2006) In vivo mechanisms of cutaneous vasodilation and vasoconstriction in humans during thermoregulatory challenges. J Appl Physiol 100(5):1709–1718

    Article  MathSciNet  Google Scholar 

  • Liu RH, Yu Q, Beebe DJ (2002) Fabrication and characterization of hydrogel-based microvalves. J Microelectromech Syst 11(1):45–53

    Article  Google Scholar 

  • Lorente S, Wechsatol W, Bejan A (2002) Tree-shaped flow structures designed by minimizing path lengths. Int J Heat Mass Transfer 45(16):3299–3312

    Article  MATH  Google Scholar 

  • Meijer GI (2010) Cooling energy-hungry data centers. Science 328(5976):318–319

    Article  Google Scholar 

  • Nguyen N-T, Wereley ST (2006) Fundamentals and applications of microfluidics, 2nd edn. Artech House, Boston

    MATH  Google Scholar 

  • O’Hayre R, Cha S-W, Colella W, Prinz FB (2005) Fuel cell fundamentals. Wiley, Hoboken

    Google Scholar 

  • Qu W, Mudawar I (2002) Experimental and numerical study of pressure drop and heat transfer in a single-phase micro-channel heat sink. Int J Heat Mass Transfer 45(12):2549–2565

    Article  Google Scholar 

  • Richter A, Kuckling D, Howitz S, Thomas G, Arndt KF (2003) Electronically controllable microvalves based on smart hydrogels: magnitudes and potential applications. J Microelectromech Syst 12(5):748–753

    Article  Google Scholar 

  • Sobhan CB, Garimella SV (2001) A Comparative analysis of studies on heat transfer and fluid flow in microchannels. Microscale Thermophys Eng 5(4):293–311

    Article  Google Scholar 

  • Tuckerman DB, Pease RFW (1981) High-performance heat sinking for VLSI. IEEE Electron Device Lett EDL-2 5:126–129

    Google Scholar 

  • van der Linden HJ, Herber S, Olthuis W, Bergveld P (2003) Stimulus-sensitive hydrogels and their applications in chemical (micro)analysis. Analyst 128(4):325–331

    Article  Google Scholar 

  • Ward JH, Bashir R, Peppas NA (2001) Micropatterning of biomedical polymer surfaces by novel UV polymerization techniques. J Biomed Mater Res 56(3):351–360

    Article  Google Scholar 

  • Wechsatol W, Lorente S, Bejan A (2002) Optimal tree-shaped networks for fluid flow in a disc-shaped body. Int J Heat Mass Transfer 45(25):4911–4924

    Article  MATH  Google Scholar 

  • Whitesides GM (2006) The origins and the future of microfluidics. Nature 442(7101):368–373

    Article  Google Scholar 

  • Yu C, Mutlu S, Selvaganapathy P, Mastrangelo CH, Svec F, Fréchet JMJ (2003) Flow control valves for analytical microfluidic chips without mechanical parts based on thermally responsive monolithic polymers. Anal Chem 75(8):1958–1961

    Article  Google Scholar 

  • Zhao B, Moore JS (2001) Fast pH- and ionic strength-responsive hydrogels in microchannels. Langmuir 17(16):4758–4763

    Article  Google Scholar 

Download references

Acknowledgments

We gratefully acknowledge NSF for supporting this work through CAREER Award #846318. We also thank Prof. C. Bielawski and Dr. J. Geng of the UT Austin Chemistry Department for their technical assistance.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alexandre K. da Silva.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 2230 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hart, R.A., da Silva, A.K. Self-optimizing, thermally adaptive microfluidic flow structures. Microfluid Nanofluid 14, 121–132 (2013). https://doi.org/10.1007/s10404-012-1030-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10404-012-1030-7

Keywords

Navigation