Abstract
This work for the first time describes a centrifugal technique for the production and manipulation of highly monodisperse water droplets (CV of droplet diameter below 2%) immersed in a continuous flow of immiscible oil. Within a given working range, droplet volumes (5–22 nL) and their mutual spacing is governed by the channel geometry and the frequency of rotation. Different regimes of liquid–liquid flows are presented. We also demonstrate capabilities like droplet splitting and sedimentation as well as the production of two colored droplets, thus setting the stage for a novel centrifugal platform for multiphase flows.
Similar content being viewed by others
References
Anna SL, Bontoux N, Stone HA (2003) Formation of dispersions using “flow focusing” in microchannels. Appl Phys Lett 82(3):364–366
Brenner T, Glatzel T, Zengerle R, Ducrée J (2005) Frequency-dependent transversal flow control in centrifugal microfluidics. Lab Chip 5(2):146–150
Cramer C, Fischer P, Windhab EJ (2004) Drop formation in a co-flowing ambient fluid. Chem Eng Sci 59(15):3045–3058
Dendukuri D, Tsoi K, Hatton TA, Doyle PS (2005) Controlled synthesis of nonspherical microparticles using microfluidics. Langmuir 21(6):2113–2116
Ducrée J, Schlosser HP, Haeberle S, Glatzel T, Brenner T, Zengerle R (2004) Centrifugal platform for high-throughput reactive micromixing. In: Laurell T, Nilsson J, Jensen KF, Harrison DJ, Kutter JP (eds) Proceedings of μTAS 2004, 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences, September 26–30, Malmö, Sweden, pp 554–556
Ducrée J, Haeberle S, Brenner T, Glatzel T, Zengerle R (2005) Patterning of flow and mixing in rotating radial microchannels. Microfluid Nanofluid 2(2):97–105
Ducrée J, Brenner T, Haeberle S, Glatzel T, Zengerle R (2006) Multilamination of flows in planar networks of rotating microchannels. Microfluid Nanofluid 2(1):78–84
Ganan-Calvo AM, Gordillo JM (2001) Perfectly monodisperse microbubbling by capillary flow focusing. Phys Rev Lett 87(27):274501
Garstecki P, Gitlin I, DiLuzio W, Whitesides GM, Kumacheva E, Stone HA (2004) Formation of monodisperse bubbles in a microfluidic flow-focusing device. Appl Phys Lett 85(13):2649–2651
Garstecki P, Stone HA, Whitesides GM (2005) Mechanism for flow-rate controlled breakup in confined geometries: a route to monodisperse emulsions. Phys Rev Lett 94(16):164501
Geschke O, Klank H, Telleman P (2004) Microsystem engineering of lab-on-a-chip devices. Wiley, Weinheim
Grumann M, Brenner T, Beer C, Zengerle R, Ducrée J (2005) Visualization of flow patterning in high-speed centrifugal microfluidics. Rev Sci Instrum 76(2):025101
Gunther A, Jhunjhunwala M, Thalmann M, Schmidt MA, Jensen KF (2005) Micromixing of miscible liquids in segmented gas–liquid flow. Langmuir 21(4):1547–1555
Haeberle S, Brenner T, Schlosser HP, Zengerle R, Ducrée J (2005a) Centrifugal micromixer. Chem Eng Technol 28(5):613–616
Haeberle S, Zengerle R, Ducrée J (2005b) Online process control for centrifugal microfluidics. In: Proceedings of Transducers 05, the 13th International Conference on Solid-State Sensors, Actuators and Microsystems, June 5–9, Seoul, Korea, pp 1525–1528
Haeberle S, Schlosser HP, Zengerle R, Ducrée J (2005c) A centrifuge-based microreactor. In: IMRET 8, 8th International Conference on Microreaction Technology, April 10–14, Atlanta, USA, p TK-129f
Haeberle S, Zengerle R, Ducrée J (2005d) Monodisperse droplet trains and segmented flow for centrifugal microfluidics. In: Proceedings 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2005), Boston, USA, pp 635–637
Haeberle S, Schmitt N, Zengerle R, Ducrée J (2006) A centrifugo-magnetically actuated gas micropump. In: Proceedings of 19th International Conference on Microelectro Mechanical Systems (MEMS 2006), Istanbul, Turkey, pp 166–169
Hessel V, Lowe H, Stange T (2002) Microchemical processing at IMM—from pioneering work to customer-specific services. Lab Chip 2(1):14N–21N
Joanicot M, Ajdari A (2005) Droplet control for microfluidics. Science 309(5736):887–888
Kim DS, Kwon TH (2006) Modeling, analysis and design of centrifugal force-driven transient filling flow into a circular microchannel. Microfluid Nanofluid 2(2):125–140
Link DR, Anna SL, Weitz DA, Stone HA (2004) Geometrically mediated breakup of drops in microfluidic devices. Phys Rev Lett 92(5):054503
Lord Rayleigh FRS (1878) On the instability of jets. Proc Lond Math Soc 10(4):4–13
Nisisako T, Torii T, Higuchi T (2004a) Novel microreactors for functional polymer beads. Chem Eng J 101(1–3):23–29
Nisisako T, Torii T, Higuchi T (2004b) Controlled production of functional polymeric microspheres using multi-phase microfluidics. In: Laurell T, Nilsson J, Jensen KF, Harrison DJ, Kutter JP (eds) Proceedings of μTAS 2004, 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences, September 26–30, Malmö, Sweden, pp 408–410
Roach LS, Song H, Ismagilov RF (2005) Controlling nonspecific protein adsorption in a plug-based microfluidic system by controlling interfacial chemistry using fluorous-phase surfactants. Anal Chem 77(3):785–796
Shestopalov IA, Tice JD, Ismagilov RF (2004) Multi-step chemical reactions performed on millisecond time scale in a microfluidic droplet-based system. Lab Chip 4:316–321
Song H, Bringer MR, Tice JD, Gerdts CJ, Ismagilov RF (2003) Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels. Appl Phys Lett 83(22):4664–4666
Sugiura S, Nakajima M, Iwamoto S, Seki M (2001) Interfacial tension driven monodispersed droplet formation from microfabricated channel array. Langmuir 17(18):5562–5566
Tan YC, Fisher JS, Lee AI, Cristini V, Lee AP (2004) Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting. Lab Chip 4(4):292–298
Thorsen T, Roberts RW, Arnold FH, Quake SR (2001) Dynamic pattern formation in a vesicle-generating microfluidic device. Phys Rev Lett 86(18):4163–4166
Utada AS, Lorenceau E, Link DR, Kaplan PD, Stone HA, Weitz DA (2005) Monodisperse double emulsions generated from a microcapillary device. Science 308(5721):537–541
Windhab EJ, Dressler M, Feigl K, Fischer P, Megias-Alguacil D (2005) Emulsion processing—from single-drop deformation to design of complex processes and products. Chem Eng Sci 60(8–9):2101–2113
Zheng B, Roach LS, Ismagilov RF (2003) Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size droplets. J Am Chem Soc 125(37):11170–11171
Acknowledgements
The authors are grateful to the partial support by the German “Landesstiftung Baden-Württemberg gGmbH”.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Haeberle, S., Zengerle, R. & Ducrée, J. Centrifugal generation and manipulation of droplet emulsions. Microfluid Nanofluid 3, 65–75 (2007). https://doi.org/10.1007/s10404-006-0106-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10404-006-0106-7