Skip to main content

Advertisement

SpringerLink
Log in

Contrast-enhanced ultrasound for needle biopsy of central lung cancer with atelectasis

  • Original Article
  • Published:
Journal of Medical Ultrasonics Aims and scope Submit manuscript

Abstract

Purpose

Contrast-enhanced ultrasound (CEUS) can distinguish between central lung cancer and atelectatic lung tissue. The aim of this study was to explore the clinical value of CEUS for biopsy in patients with central lung cancer with obstructive atelectasis.

Methods

One hundred and twelve patients were selected and CEUS was performed to display central lung cancer and atelectatic lung tissue. The front edge of central lung cancer was punctured with a needle, avoiding the necrotic area, under the guidance of CEUS.

Results

All of the 112 lesions were diagnosed with a clear central lung cancer mass and atelectatic lung tissue. In 104 cases, the central lung cancer mass presented with a “slow-in and fast-out” pattern compared to atelectatic lung tissue. In eight cases, the central lung cancer mass presented with a “fast-in and fast-out” pattern compared to atelectatic lung tissue. The mean number of punctures was 2.6, and the success rate of puncture biopsy was 98%. Of the 112 patients, six cases had hemoptysis during the procedure and 10 patients had bloody sputum in the postoperative period. No complications were found in the other cases.

Conclusion

CEUS has important clinical value for needle biopsy of central lung cancer with atelectasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Dewall RJ. Ultrasound elastography: principles, techniques, and clinical applications. Crit Rev Biomed Eng. 2013;41:1–19.

    Article  PubMed  Google Scholar 

  2. X MA, Zhang B, Ling W, Liu R, Jia H, Zhu F, Wang M, Liu H, Huang J, Liu L. Contrast-enhanced sonography for the identification of benign and malignant thyroid nodules: Systematic review and meta-analysis. J Clin Ultrasound. 2016;44:199–209.

    Article  Google Scholar 

  3. Sheth S, Hamper UM, Stanley DB, Wheeler JH, Smith PA. US guidance for thoracic biopsy: a valuable alternative to CT. Radiology. 1999;210:721–6.

    Article  PubMed  CAS  Google Scholar 

  4. Ofiara LM, Navasakulpong A, Ezer N, Gonzalez AV. The importance of a satisfactory biopsy for the diagnosis of lung cancer in the era of personalized treatment. Curr Oncol. 2012;19:S16–23.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Cao BS, Wu JH, Li XL, Deng J, Liao GQ. Sonographically guided transthoracic biopsy of peripheral lung and mediastinal lesions: role of contrast-enhanced sonography. J Ultrasound Med. 2011;30:1479–90.

    Article  PubMed  Google Scholar 

  6. Sartori S, Tombesi P. Emerging roles for transthoracic ultrasonography in pulmonary diseases. World J Radiol. 2010;2:203–14.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Jiang J, Huang L, Zhang H, Ma W, Shang X, Zhou Q, Gao Y, Yu S, Qi Y. Contrast-enhanced sonography of thyroid nodules. J Clin Ultrasound. 2015;43:153–6.

    Article  PubMed  CAS  Google Scholar 

  8. Wu JP, Shu R, Zhao YZ, Ma GL, Xue W, He QJ, Hao MN, Liu Y. Comparison of contrast-enhanced ultrasonography with virtual touch tissue quantification in the evaluation of focal liver lesions. J Clin Ultrasound. 2016;44:347–53.

    Article  PubMed  Google Scholar 

  9. Barr RG. Off-label use of ultrasound contrast agents for abdominal imaging in the United States. J Ultrasound Med. 2013;32:7–12.

    Article  PubMed  Google Scholar 

  10. Di Vece F, Tombesi P, Ermili F, Sartori S. Contrast-enhanced ultrasound (CEUS) and CEUS-guided biopsy in the diagnosis of lung abscess in a patient with achalasia: Case report. Interv Med Appl Sci. 2013;5:31–3.

    PubMed  PubMed Central  Google Scholar 

  11. Luo W, Zhou X, Yu M, He G, Zheng X, Li Q, Liu Q, Han Z, Zhang J, Qian Y. Ablation of high-intensity focused ultrasound assisted with SonoVue on rabbit VX2 liver tumors: sequential findings with histopathology, immunohistochemistry, and enzyme histochemistry. Ann Surg Oncol. 2009;16:2359–68.

    Article  PubMed  Google Scholar 

  12. Khankan AA, Al-Muaikeel M. Image-guided percutaneous transthoracic biopsy in lung cancer–emphasis on CT-guided technique. J Infect Public Health. 2012;5(Suppl 1):S22–30.

    Article  PubMed  Google Scholar 

  13. Birchard KR. Transthoracic needle biopsy. Semin Intervent Radiol. 2011;28:87–97.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Dasgupta A, Mehta AC. Transbronchial needle aspiration. An underused diagnostic technique. Clin Chest Med. 1999;20:39–51.

    Article  PubMed  CAS  Google Scholar 

  15. Boskovic T, Stanic J, Pena-Karan S, Zarogoulidis P, Drevelegas K, Katsikogiannis N, Machairiotis N, Mpakas A, Tsakiridis K, Kesisis G, Tsiouda T, Kougioumtzi I, Arikas S, Zarogoulidis K. Pneumothorax after transthoracic needle biopsy of lung lesions under CT guidance. J Thorac Dis. 2014;6(Suppl 1):S99–107.

    PubMed  PubMed Central  Google Scholar 

  16. Yang RM, Li L, Wei XH, Guo YM, Huang YH, Lai LS, Chen AM, Liu GS, Xiong WF, Luo LP, Jiang XQ. Differentiation of central lung cancer from atelectasis: comparison of diffusion-weighted MRI with PET/CT. PLoS One. 2013;8:e60279.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  17. Koegelenberg CF, Von Groote-Bidlingmaier F, Bolliger CT. Transthoracic ultrasonography for the respiratory physician. Respiration. 2012;84:337–50.

    Article  PubMed  Google Scholar 

  18. Stark DD, Moss AA, Goldberg HI, Davis PL, Federle MP. Magnetic resonance and CT of the normal and diseased pancreas: a comparative study. Radiology. 1984;150:153–62.

    Article  PubMed  CAS  Google Scholar 

  19. Gorg C, Bert T, Kring R. Contrast-enhanced sonography of the lung for differential diagnosis of atelectasis. J Ultrasound Med. 2006;25:35–9.

    Article  PubMed  Google Scholar 

  20. Gorg C, Kring R, Bert T. Transcutaneous contrast-enhanced sonography of peripheral lung lesions. AJR Am J Roentgenol. 2006;187:W420–9.

    Article  PubMed  Google Scholar 

  21. Sartori S, Postorivo S, Vece FD, Ermili F, Tassinari D, Tombesi P. Contrast-enhanced ultrasonography in peripheral lung consolidations: what’s its actual role? World J Radiol. 2013;5:372–80.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Gorg C. Transcutaneous contrast-enhanced sonography of pleural-based pulmonary lesions. Eur J Radiol. 2007;64:213–21.

    Article  PubMed  Google Scholar 

  23. Redman R, Zalaznick H, Mazzaferri EL, Massoll NA. The impact of assessing specimen adequacy and number of needle passes for fine-needle aspiration biopsy of thyroid nodules. Thyroid. 2006;16:55–60.

    Article  PubMed  Google Scholar 

  24. Mccormack M, Duclos A, Latour M, Mccormack MH, Liberman D, Djahangirian O, Bergeron J, Valiquette L, Zorn K. Effect of needle size on cancer detection, pain, bleeding and infection in TRUS-guided prostate biopsies: a prospective trial. Can Urol Assoc J. 2012;6:97–101.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Yildirim E, Kirbas I, Harman A, Ozyer U, Tore HG, Aytekin C, Boyvat F. CT-guided cutting needle lung biopsy using modified coaxial technique: factors effecting risk of complications. Eur J Radiol. 2009;70:57–60.

    Article  PubMed  Google Scholar 

Download references

Funding

This work is supported by Social Development Project of Hangzhou Science Committee (20170533B92).

Author information

Authors and Affiliations

  1. Department of Ultrasound, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China

    Zhikai Lei

  2. Department of Ultrasound, Hangzhou Tumor Hospital, Hangzhou, China

    Jun Lou & Zhuying Lv

  3. Department of Ultrasound, Hangzhou First People’s Hospital, Hangzhou, China

    Lingyun Bao

Authors
  1. Zhikai Lei
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jun Lou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lingyun Bao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zhuying Lv
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zhikai Lei.

Ethics declarations

Ethical statements

This study was approved by the Ethics Committee of Hangzhou First People’s Hospital. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent was obtained from all patients for being included in the study.

IRB

This study was approved by the Ethics Committee of Hangzhou First People’s Hospital (No. 054-01).

Conflict of interest

The authors declare that they have no conflicts of interest.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lei, Z., Lou, J., Bao, L. et al. Contrast-enhanced ultrasound for needle biopsy of central lung cancer with atelectasis. J Med Ultrasonics 45, 461–467 (2018). https://doi.org/10.1007/s10396-017-0851-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10396-017-0851-0

Keywords

Search

Navigation