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Impact of parametric imaging on contrast-enhanced ultrasound of breast cancer

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Abstract

Purpose

To prospectively evaluate the usefulness of contrast-enhanced ultrasound (CEUS) using parametric imaging for breast cancer in a multicenter study.

Methods

A total of 65 patients with breast cancer were included in this study. CEUS was performed, and still images on peak time (S), accumulated images (A) and parametric images (P) were generated from the raw data. Four blind reviewers ranked the best visible images as first place, and determined second and third place consecutively. We compared the average ranking of each image. The maximal diameter of the tumor determined on ultrasonography and MRI was compared with the corresponding pathological maximal diameter for 48 of the 65 patients. The correlation between the diameter determined by two experts and two beginners was analyzed.

Results

The average rank of visibility was as follows: P, 1.44; A, 2.04; and S, 2.52. The correlation between each image and the pathology was as follows: P, r = 0.664; A, r = 0.630; S, r = 0.717; and MRI, r = 0.936. There were no significant differences among the correlation between the experts and beginners in each image.

Conclusions

The use of parametric imaging improves the visibility of CEUS. The maximal diameter of the tumor determined on CEUS correlates substantially with the pathology.

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Author information

Authors and Affiliations

  1. Department of Breast Surgery, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Aya Noro & Tomoko Ogawa

  2. Department of Breast Surgery, Nabari City Hospital, Nabari, Mie, Japan

    Takashi Nakamura

  3. Department of Endoscopy and Ultrasound, Nara Medical University Hospital, Kashihara, Nara, Japan

    Toshiko Hirai

  4. Department of Radiology, Nara Medical University Hospital, Kashihara, Nara, Japan

    Masayo Haga

  5. Department of Breast Surgery, Nara Medical University Hospital, Kashihara, Nara, Japan

    Toyoki Kobayashi

  6. Department of Pathology, Mie University Hospital, Tsu, Mie, Japan

    Akinobu Hayashi & Yuji Kozuka

  7. Department of Pathology, Nara Medical University Hospital, Kashihara, Nara, Japan

    Tokiko Nakai

  8. Center of Development of Clinical Study, Mie University Hospital, Tsu, Mie, Japan

    Toru Ogura

Authors
  1. Aya Noro
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  2. Takashi Nakamura
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  3. Toshiko Hirai
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  4. Masayo Haga
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  5. Toyoki Kobayashi
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  6. Akinobu Hayashi
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  7. Yuji Kozuka
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  8. Tokiko Nakai
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  9. Toru Ogura
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  10. Tomoko Ogawa
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Corresponding author

Correspondence to Aya Noro.

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Conflict of interest

All authors declare that they have no conflict of interest.

Ethical standards

This study was performed at Mie University Hospital and Nara Medical University Hospital. The study was approved by the Ethical Review Board of both hospitals (UMIN000013345). Written informed consent was obtained from all patients.

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Cite this article

Noro, A., Nakamura, T., Hirai, T. et al. Impact of parametric imaging on contrast-enhanced ultrasound of breast cancer. J Med Ultrasonics 43, 227–235 (2016). https://doi.org/10.1007/s10396-015-0692-7

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  • DOI: https://doi.org/10.1007/s10396-015-0692-7

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