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Usefulness of measurement of carotid arterial wall elasticity distribution in detection of early-stage atherosclerotic lesions caused by cigarette smoking

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Abstract

Purpose

The aim of this study was to evaluate early-stage changes in the arterial wall caused by smoking.

Methods

A newly developed real-time ultrasonic measurement system was used to measure the elasticity distribution of the carotid arterial intima-media complex in 53 healthy male volunteers (mean age: 37.6 years), including 27 smokers. Simultaneous measurement of the elasticity distribution and intima-media thickness (IMT) was performed at six locations in the bilateral carotid arteries.

Results

The mean elastic modulus in the radial direction (Er) of the carotid arterial area where the IMT was less than 1.1 mm in smokers was larger than that in age-matched nonsmokers. There were no significant correlations between IMT and Er at the same location. However, a significant positive correlation was observed between the maximum IMT (maxIMT) and that of Er (maxEr) in six locations. In smokers, maxEr had a better correlation with the smoking index, and areas of IMT less than 1.1 mm containing harder lesions of Er ≥ 160 kPa were significantly more frequent than in nonsmokers.

Conclusion

Measurement of carotid arterial wall elasticity is useful for detecting distortion in the intramural elasticity distribution that occurs prior to IMT thickening caused by smoking as an early-stage atherosclerotic sign.

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Authors and Affiliations

  1. Department of Internal Medicine, Tohoku Kosai Hospital, 2-3-11 Kokubun, Aoba, Sendai, 980-0803, Japan

    Toshio Yamagishi

  2. Healthcare Business Company, Matsushita Electric Industrial Co., Yokohama, Japan

    Makoto Kato

  3. Department of Medical Sciences, Graduate School of Medicine, Tohoku University, Sendai, Japan

    Yoshiro Koiwa

  4. Department of Electronic Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan

    Hideyuki Hasegawa & Hiroshi Kanai

Authors
  1. Toshio Yamagishi
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  2. Makoto Kato
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  3. Yoshiro Koiwa
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  4. Hideyuki Hasegawa
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  5. Hiroshi Kanai
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Corresponding author

Correspondence to Toshio Yamagishi.

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Yamagishi, T., Kato, M., Koiwa, Y. et al. Usefulness of measurement of carotid arterial wall elasticity distribution in detection of early-stage atherosclerotic lesions caused by cigarette smoking. J Med Ultrasonics 33, 203–210 (2006). https://doi.org/10.1007/s10396-006-0111-1

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  • DOI: https://doi.org/10.1007/s10396-006-0111-1

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