Abstract
Fewer than 1 % of gastrointestinal stromal tumors (GISTs) are of the esophagus. This report describes a 63-year-old female diagnosed with mixed spindle/epithelioid cell GIST of the esophagus. She was admitted to our hospital with symptoms of nausea and hematemesis. Preoperative imaging showed a huge submucosal tumor in the lower thoracic and abdominal esophagus. Pathologic examination of an endoscopic biopsy sample suggested squamous cell carcinoma. She underwent subtotal esophagectomy and reconstruction with a gastric tube. Postoperative pathological diagnosis revealed a mixed spindle/epithelioid cell type GIST. The tumor measured 8 × 6 cm, with 30–50 mitotic counts per high power field, immunohistochemical positivity for C-kit (CD117) and CD34 and high risk by modified Fletcher classification. Adjuvant chemotherapy with imatinib mesylate was started 3 months after surgery. Preoperative pathological examination, including staining for CD117 and CD34, of biopsy samples of apparently stromal tumors may be required to rule out rare subtypes of GIST.
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References
Lott S, Schmieder M, Mayer B, et al. Gastrointestinal stromal tumors of the esophagus: evaluation of a pooled case series regarding clinicopathological features and clinical outcome. Am J Cancer Res. 2014;5:333–43.
Miettinen M, Makhlouf H, Sobin LH, et al. Gastrointesinal stromal tumors of the jejunum and ileum: a clinicopathologic, immunohistochemical, and molecular genetic study of 906 cases with long-term follow-up. Am J Surg Pathol. 2006;30:477–89.
Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998;279:577–80.
Miettinen M, Lasota J, Sobin LH, et al. Gastrointesinal stromal tumors of the stomach in children and young adults: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases with long-term follow-up. Am J Surg Pathol. 2005;29:1373–81.
Cichoz-Lach H, Kasztelan-Szczerbinska B, Slomka M, et al. Gastrointestinal stromal tumors: epidemiology, clinical picture, diagnosis, prognosis and treatment Por Arch Med Wewn. 2008;118:216–21.
Lee HJ, Park SI, Kim DK, et al. Surgical resection of esophageal gastrointestinal stromal tumors. Ann Thorac Surg. 2009;87:1569–71.
Dei Tos AP, Laurino L, Bearzi I, et al. Gastrointestinal stromal tumors: the histology report. Dig Liver Dis. 2011;43:304–9.
Miwako A, Masahiro T, Yoichi T, et al. EUS-FNA for esophageal and mediastinal lesions. Endoscop Dig. 2011;23:1337–46.
Mekky MA, Yamao K, Sawaki A, et al. Diagnostic utility of EUS-guided FNA in patients with gastric submucosal tumors. Gastrointest Endosc. 2010;71:913–9.
Wong NA, Mangwana S, et al. KIT and PDGFRA mutational analyses of mixed cell-type gastrointestinal stromal tumors. Histopathology. 2007;51:758–62.
Attili SV, Amamda B, Mandapal T, et al. Factors influencing progression-free survival in gastrointestinal stromal tumors with special reference to pathologic features, cytogenetics, and radiologic response. Gastrointest Cancer Res. 2011;4:173–7.
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The study protocol was approved by our institutional review board, and the patient provided written informed consent for treatment and for publication of this report.
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Korehisa, S., Saeki, H., Nakashima, Y. et al. Mixed spindle and epithelioid cell type gastrointestinal stromal tumor of the esophagus: a case report. Esophagus 13, 301–305 (2016). https://doi.org/10.1007/s10388-016-0525-9
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DOI: https://doi.org/10.1007/s10388-016-0525-9