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A case of verrucous squamous cell carcinoma of the esophagus

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Abstract

We report a rare case of verrucous squamous cell carcinoma (VSC) of the esophagus. A 73-year-old woman presented to our hospital with dysphagia. On gastrointestinal endoscopy, a white mass with a cauliflower-like appearance (3.5 cm in diameter) was detected in the upper esophagus at 23 cm from the incisors. Histological examination of a biopsy specimen revealed squamous epithelial hyperplasia and no malignancy. During 17 months of follow-up by repeated endoscopy, the lesion showed no marked changes in appearance. However, reexamination of the specimen obtained by partial endoscopic mucosal resection (EMR) using a jumbo biopsy forceps revealed very well differentiated squamous cell carcinoma corresponding to VSC. The clinical and histopathological characteristics of esophageal VSC are discussed on the basis of the published literature.

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References

  1. Ackermann LV. Verrucous carcinoma of the oral cavity. Surgery (St. Louis) 1948;23:670–678.

    Google Scholar 

  2. Perez CA, Kraus FT, Evans JC, Powers WE. Anaplastic transformation in verrucous carcinoma of the oral cavity after radiation therapy. Radiology 1966;86:108–115.

    CAS  PubMed  Google Scholar 

  3. Duckworth R. Verrucous carcinoma presenting as mandibular osteomyelitis. Br J Surg 1961;49:332–337.

    Article  CAS  PubMed  Google Scholar 

  4. Goethals PL, Hnison EG, Devine KD. Verrucous carcinoma of the oral cavity. Am J Surg 1963;106:845–851.

    Article  CAS  PubMed  Google Scholar 

  5. Kraus FT, Perez-Mesa C. Verrucous carcinoma. Clinical and pathologic study of 105 cases involving oral cavity, larynx and genitalia. Cancer (Phila) 1966;19:26–38.

    Article  CAS  Google Scholar 

  6. Minielly JA, Harrison EG Jr, Fontana RS, Payne WS. Verrucous squamous cell carcinoma of the esophagus. Cancer (Phila) 1967;20:2078–2087.

    Article  CAS  Google Scholar 

  7. Parkinson AT, Haidak GL, McInerney RP. Verrucous squamous cell carcinoma of the esophagus following lye stricture. Chest 1971;57:489–492.

    Article  Google Scholar 

  8. Meyerowitz BR, Shea LT. The natural history of squamous verrucose carcinoma of the esophagus. J Thorac Cardiovasc Surg 1971;61:646–649.

    CAS  PubMed  Google Scholar 

  9. Sridhar C, Zeskind HJ, Rising JA. Verrucous squamous-cell carcinoma: an unusual tumor of the esophagus. Radiology 1980;136:614.

    CAS  PubMed  Google Scholar 

  10. Sakurai T, Fuchigami T, Omae T, Iwashita A, Kume K, Asano S. Bleomycin in verrucous squamous cell carcinoma of the oesophagus. Postgrad Med J 1983;59:578–580.

    Article  CAS  PubMed  Google Scholar 

  11. Agha FP, Weatherbee L, Sams JS. Verrucous carcinoma of the esophagus. Am J Gastroenterol 1984;79:844–849.

    CAS  PubMed  Google Scholar 

  12. Barbier PA, Luder PJ, Wagner HE. Verrucous acanthosis: so-called verrucous carcinoma of the esophagus. Z Gastroenterol 1987;25:93–97.

    CAS  PubMed  Google Scholar 

  13. Koerfgen HP, Husemann B, Giedl J, Hohenberger W. Verrucous carcinoma of the esophagus. Endoscopy 1988;20:326–329.

    Article  CAS  PubMed  Google Scholar 

  14. Kojima T, Minami K, Kouyama K, Kawaguti M, Saitou T, Ashizawa S. A case of verrucous squamous cell carcinoma of the esophagus. Gastroenterol Endosc 1988;30:582–587.

    Google Scholar 

  15. Jasim KA, Bateson MC. Verrucous carcinoma of the oesophagus: a diagnostic problem. Histopathology (Oxf) 1990;17:473–475.

    Article  CAS  Google Scholar 

  16. Biemond P, ten Kate FJ, van Blankenstein M. Esophageal verrucous carcinoma: histologically a low-grade malignancy but clinically a fatal disease. J Clin Gastroenterol 1991;13:102–107.

    Article  CAS  PubMed  Google Scholar 

  17. Roach E, Barr G. Verrucous carcinoma of the oesophagus and achalasia. J Gastroenterol Hepatol 1993;8:107–109.

    Article  CAS  PubMed  Google Scholar 

  18. Garrard CL, Sheih WJ, Cohn RA. Verrucous carcinoma of the esophagus: surgical treatment for an often fatal disease. Am Surg 1994;60:613–616.

    CAS  PubMed  Google Scholar 

  19. Kavin H, Yaremko L, Valaitis J, Chowdhury L. Chronic esophagitis evolving to verrucous squamous carcinoma: possible role of exogenous chemical carcinogens. Gastroenterology 1996;110:904–914.

    Article  CAS  PubMed  Google Scholar 

  20. Malik AB, Bidani JA, Rich HG, McCully KS. Long-term survival in a patient with verrucous carcinoma of the esophagus. Am J Gastroenterol 1996;91:1031–1033.

    CAS  PubMed  Google Scholar 

  21. Tajiri H, Muto M, Boku N, Ohtsu A, Yoshida S, Kawahara H. Verrucous carcinoma of the esophagus completely resected by endoscopy. Am J Gastroenterol 2000;95:1076–1077.

    Article  CAS  PubMed  Google Scholar 

  22. Ereño C, Lopez JI, Loizate A, Bilbao FJ. Verrucous carcinoma of the esophagus. Endoscopy 2001;33:297.

    Article  PubMed  Google Scholar 

  23. Osborn NK, Keate RF, Trastek VF, Nguyen CC. Verrucous carcinoma of the esophagus: clinicopathophysiologic features and treatment of a rare entity. Dig Dis Sci 2003;48:465–474.

    Article  CAS  PubMed  Google Scholar 

  24. Pfitzmann R, Abou-Rebyeh H, Krenn V, Settmacher U, Neuhaus P. Verrucous carcinoma of the esophagus: a rare entity. Zentralbl Chir 2004;129:70–72.

    Article  CAS  PubMed  Google Scholar 

  25. Devlin S, Falck V, Urbanski SJ, Mitchell P, Romagnuolo J. Verrucous carcinoma of the esophagus eluding multiple sets of endoscopic biopsies and endoscopic ultrasound: a case report and review of the literature. Can J Gastroenterol 2004;18:459–462.

    PubMed  Google Scholar 

  26. Liberale G, De Simone P, Snoeck R, Féron P, Gelin M, El Nakadi I. Verrucous carcinoma of the esophagus. A case report. Minerva Chir 2005;60:61–65.

    CAS  PubMed  Google Scholar 

  27. Miyako H, Makuuti H, Shimada H, Chino O, Nishi T, Kenmochi T, et al. Verrucous carcinoma of esophagus, superficial type associated with candidal infection. Prog Dig Endosc 2005;66(2):48–49.

    Google Scholar 

  28. Mizutani S, Oyama T, Uchikoshi H, Nakahara M, Tsujimoto M, Nakao K. A case of verrucous carcinoma of the esophagus with successful resection. J Jpn Surg Assoc 2005;66:2146–2150.

    Google Scholar 

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Correspondence to Jiro Fujimoto.

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Oh, K., Nishigami, T., Takubo, K. et al. A case of verrucous squamous cell carcinoma of the esophagus. Esophagus 6, 263–267 (2009). https://doi.org/10.1007/s10388-009-0208-x

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