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Comparison of myopia progression between children wearing three types of orthokeratology lenses and children wearing single-vision spectacles

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate factors related to myopia progression in children wearing either orthokeratology (OK) lenses or single-vision spectacles (SVS) for 2 years.

Study design

Pooled-analysis retrospective intervention study.

Methods

This study involved 105 school-aged children wearing SVS who participated in the multi-center Myovision Study and 89 school-aged children wearing one of 3 OK lens types [Menicon Z Night (M, n = 27), αORTHO®-K (A, n = 32), and Emerald™ (E, n = 30)]. In the OK-lens patients, last examination was performed at ≥ 3-weeks post lens-wear discontinuation. Of the subjects, 102 SVS-Group and 79 OK-Group (M: n = 24, A: n = 28, and E: n = 27) children completed all examinations. A relationship between refractive error (RE) change and 7 factors (correction methods, baseline age, baseline RE, baseline axial length, gender, right or left eye, and follow-up period) was derived by multiple regression modeling. Via those same methods, we investigated the relationship between RE change and 7 factors including 3 OK-lens corrections.

Results

Related influence factors were correction method (0.85 D myopia reduction in the OK Group, P < 0.001), baseline age (0.16 D myopia reduction in older-age patients, P < 0.001), and baseline RE (0.12 D myopia reduction per 1 D myopia, P = 0.01). No relationship was found between RE change and OK-lens type. No serious adverse events occurred.

Conclusion

Regardless of OK lens design, myopia progression in school-aged children was suppressed. The effect was examined not only via axial-length elongation but also RE change, and the myopia control effect by OK lenses was found to be 0.85 D over the 2-year period.

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Acknowledgements

The authors appreciate the members of Multi-Center Clinical Trial of the Myovision Study Group (T. Fujikado, H. Kanda, T. Oshika, T. Hiraoka, S. Hasebe, K. Ohno-Matsui, S. Ishiko, and H. Torii) who provided the control data. The authors wish to thank John Bush for reviewing the manuscript.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan

    Yo Nakamura, Osamu Hieda & Chie Sotozono

  2. Department of Biostatistics, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

    Isao Yokota

  3. Department of Biostatistics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Satoshi Teramukai

  4. Department of Frontier Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Shigeru Kinoshita

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Correspondence to Yo Nakamura.

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Conflicts of interest

Y. Nakamura, None; O. Hieda, None; I. Yokota, None; S. Teramukai, None; C. Sotozono, Lecture fee (Otsuka, Santen, Senju, TOA); S. Kinoshita, Lecture fee (Otsuka, Santen, Senju, Kowa), Senju and the author own the patent for the use of ROCK inhibitor. CorneaGen and the author own the patent for the use of ROCK inhibitor. Santen and the author own the patent for glaucoma-related genes. Sysmex and the author are applicants for the patent for SJS-related genes.

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Corresponding Author: Yo Nakamura

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 19 kb)

10384_2021_854_MOESM2_ESM.tif

Supplementary file2 Supplementary Fig. 1a RE change over the 2-year study period in the OK Group only (subgroup analysis). There was no significant difference in RE change among the three different-type design OK lens groups (right eye: P = 0.47, left eye: P = 0.38, one-way ANOVA). Dot filled square box: Right eye, Slant line filled square box: Left eye. (TIF 81 kb)

10384_2021_854_MOESM3_ESM.tif

Supplementary file3 Supplementary Fig. 1b AL elongation over the 2-year study period in the OK Group only (subgroup analysis). There was no significant difference in AL elongation among the three different-type design OK lens groups (right eye: P = 0.65, left eye: P = 0.38, one-way ANOVA). Dot filled square box: Right eye, Slant line filled square box: Left eye. (TIF 80 kb)

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Nakamura, Y., Hieda, O., Yokota, I. et al. Comparison of myopia progression between children wearing three types of orthokeratology lenses and children wearing single-vision spectacles. Jpn J Ophthalmol 65, 632–643 (2021). https://doi.org/10.1007/s10384-021-00854-4

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  • DOI: https://doi.org/10.1007/s10384-021-00854-4

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