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Increased choroidal blood flow velocity with regression of unilateral acute idiopathic maculopathy

  • Clinical Investigation
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Abstract

Purpose

The pathogenesis of unilateral acute idiopathic maculopathy (UAIM) is unknown. The aim of this study was to quantitatively examine changes in choroidal circulation hemodynamics in patients with UAIM.

Methods

This was a retrospective observational case-series which included five eyes of four patients with UAIM. All UAIM eyes and the fellow eyes in remaining three patients were studied using laser speckle flowgraphy (LSFG) to evaluate the mean blur rate (MBR), a quantitative index of relative blood flow velocity. The changes in MBR between the initial visit and after 1 and 3 months were statistically analyzed. Subfoveal choroidal thickness was measured in three UAIM eyes by enhanced depth imaging optical coherence tomography.

Results

The mean logMAR value of best-corrected visual acuity in the UAIM eyes significantly improved (P = 0.04) with recovery of outer retinal morphology. The average MBR of the UAIM eyes significantly increased at 1 (+21.7 % baseline value; P = 0.003) and 3 months (+32.5 % baseline value; P = 0.001), whereas the fellow eyes did not show this tendency. The mean values of subfoveal choroidal thickness decreased with time (316.0 µm at baseline, 186.6 µm at 1 month, and 167.3 µm at 3 months).

Conclusions

These results reveal that there is a significant elevation of choroidal blood flow velocity and substantial reduction of choroidal thickness with regression of UAIM, suggesting that impaired choroidal circulation may be involved in the pathogenesis of UAIM.

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Conflicts of interest

Y. Hashimoto, None; W. Saito, None; M. Saito, None; K. Hirooka, None; S. Mori, None; K. Noda, None; S. Ishida, None.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Kiriko Hirooka, Shohei Mori, Kousuke Noda & Susumu Ishida

  2. Department of Ocular Circulation and Metabolism, Hokkaido University Graduate School of Medicine, Nishi 7, Kita 15, Kita-ku, Sapporo, 060-8638, Japan

    Wataru Saito, Kousuke Noda & Susumu Ishida

Authors
  1. Yuki Hashimoto
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  2. Wataru Saito
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  3. Michiyuki Saito
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  4. Kiriko Hirooka
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  5. Shohei Mori
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  6. Kousuke Noda
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  7. Susumu Ishida
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Corresponding author

Correspondence to Wataru Saito.

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Hashimoto, Y., Saito, W., Saito, M. et al. Increased choroidal blood flow velocity with regression of unilateral acute idiopathic maculopathy. Jpn J Ophthalmol 59, 252–260 (2015). https://doi.org/10.1007/s10384-015-0380-6

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  • DOI: https://doi.org/10.1007/s10384-015-0380-6

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