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Visual loss and perimetric sensitivity in eyes with retinitis pigmentosa

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the various perimetric parameters that best predict reduction of best-corrected visual acuity (BCVA) to worse than 0.5 in the near future in eyes with retinitis pigmentosa (RP).

Methods

The most recent records obtained by Humphrey Field Analyzer (HFA) central 10-2 perimetry were studied for the right eyes of 123 patients (60 men and 63 women) with typical RP. The correlation between various parameters of perimetric sensitivity and BCVA was retrospectively studied. The receiver operating characteristic (ROC) curves were used to find the best parameter to discriminate eyes with BCVA ≥0.5 from those with BCVA <0.5.

Results

Spearman rank correlation coefficients with logMAR BCVA were the highest for the foveal threshold (FT) and mean sensitivity of the test points within 1.4° of the fixation point (MS1.4). The ROC curve analysis revealed that the area under the curve was the largest for the MS1.4 among all the perimetric parameters for discriminating eyes with BCVA ≥0.5 from those with BCVA <0.5. The cutoff value of 30 dB showed 100 % specificity and 57 % sensitivity.

Conclusions

The risk of vision decreasing below 0.5 in the near future may be predicted when the mean sensitivity within 1.4° of the fixation point in the HFA 10-2 reaches 30 dB in eyes with RP.

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Acknowledgments

This study was supported in part by a JSPS KAKENHI Grant (no. 22591937) (Grant-in-aid for scientific Research [C]) from the Japan Society for the Promotion of Science. The author has no financial conflicts of interest to declare. The author thanks the members of the Retina Clinic of the University of Yamanashi Hospital, including Kyoko Kohno, Daisuke Yuzurihara, Toshihito Ariizumi, Tadasuke Hatori, Nami Chiba, Yoichi Sakurada, and Naohiko Tanabe, for their contributions in examining the participating patients. The author also thanks Naoko Matsui, Miho Sakurabayashi, Keiko Hanada, Takako Tanaka, and Yuki Suzuki for their assistance in conducting HFA perimetry.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan

    Hiroyuki Iijima

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  1. Hiroyuki Iijima
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Correspondence to Hiroyuki Iijima.

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Iijima, H. Visual loss and perimetric sensitivity in eyes with retinitis pigmentosa. Jpn J Ophthalmol 57, 563–567 (2013). https://doi.org/10.1007/s10384-013-0271-7

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  • DOI: https://doi.org/10.1007/s10384-013-0271-7

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