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Vasodilatory effects of antivascular endothelium growth factor (VEGF) antibody, corticosteroid, and nitric oxide on the posterior ciliary arteries

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Abstract

Purpose

The purpose of this study was to determine whether an antivascular endothelium growth factor (VEGF) antibody, a corticosteroid, and sodium nitroprusside (SNP) [a nitric oxide (NO) donor] are possible treatment agents for nonarteritic ischemic optic neuropathy (NAION) by clarifying their effects on high-K (potassium) solution-induced contraction in isolated rabbit and human posterior ciliary arteries (PCA).

Methods

Vascular ring segments were cut from the distal section of the PCA and mounted in a double-myograph system. After obtaining the maximal contraction following the administration of high-K solution, bevacizumab as an anti-VEGF antibody, methylprednisolone as a corticosteroid, and SNP were administered separately. When a vasodilatory effect was observed, carboxy-PTIO (a NO scavenger) or l-NAME (a NO synthase inhibitor) was administered.

Results

Bevacizumab did not relax either the rabbit or the human PCA, whereas methylprednisolone relaxed both. Neither carboxy-PTIO nor l-NAME inhibited methylprednisolone-induced relaxation. SNP relaxed the rabbit PCA. Carboxy-PTIO inhibited SNP-induced relaxation, but l-NAME did not. In the human PCA, the vasodilatory effect of SNP was present, but weaker than in the rabbit PCA.

Conclusions

A corticosteroid has NO-independent vasodilatory effects. Exogenous NO has a weak dilating effect in the human PCA. Therefore, corticosteroid could be effective for the treatment of NAION.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki, Miyazaki, 889-1692, Japan

    Hideki Chuman, Naoko Kawano, Maki Kozawa & Nobuhisa Nao-i

Authors
  1. Hideki Chuman
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  2. Naoko Kawano
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  3. Maki Kozawa
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  4. Nobuhisa Nao-i
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Correspondence to Hideki Chuman.

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Chuman, H., Kawano, N., Kozawa, M. et al. Vasodilatory effects of antivascular endothelium growth factor (VEGF) antibody, corticosteroid, and nitric oxide on the posterior ciliary arteries. Jpn J Ophthalmol 57, 320–326 (2013). https://doi.org/10.1007/s10384-012-0179-7

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  • DOI: https://doi.org/10.1007/s10384-012-0179-7

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