Skip to main content

Advertisement

SpringerLink
Log in

Prognostic risk factors for failure of trabeculectomy with mitomycin C after vitrectomy

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the prognostic risk factors for failure of trabeculectomy with mitomycin C (MMC) in vitrectomized eyes.

Methods

Retrospective cohort study. We reviewed the medical records of 116 patients (116 eyes) treated at Kumamoto University Hospital. The primary endpoints were persistent intraocular pressure of >21 mmHg, deterioration of visual acuity to no light perception, or additional glaucoma procedures. Multivariable analysis was performed with the Cox proportional hazards model.

Results

The mean follow-up period was 36.5 months (range, 0.5–134.1 months). The probability of success 1 year after trabeculectomy was 55.1 %, 2 years after was 45.3 %, and 3 years after was 43.1 %. The multivariable model showed that higher preoperative intraocular pressure (IOP) [relative risk (RR), 1.05/mmHg; P = 0.0077] and neovascular glaucoma (NVG) (RR, 1.88; P = 0.049) were prognostic factors for surgical failure.

Conclusions

The prognostic factors for surgical failure of trabeculectomy with MMC in vitrectomized eyes are a higher preoperative IOP and NVG.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Kiuchi Y, Sugimoto R, Nakae K, Saito Y, Ito S. Trabeculectomy with mitomycin C for treatment of neovascular glaucoma in diabetic patients. Ophthalmologica. 2006;220:383–8.

    Article  PubMed  CAS  Google Scholar 

  2. Takihara Y, Inatani M, Fukushima M, Iwao K, Iwao M, Tanihara H. Trabeculectomy with mitomycin C for neovascular glaucoma: prognostic factors for surgical failure. Am J Ophthalmol. 2009;147:912–8, 918e1.

    Google Scholar 

  3. Kaburaki T, Koshino T, Kawashima H, Numaga J, Tomidokoro A, Shirato S. Initial trabeculectomy with mitomycin C in eyes with uveitic glaucoma with inactive uveitis. Eye (Lond). 2009;23:1509–17.

    Article  CAS  Google Scholar 

  4. Broadway DC, Chang LP. Trabeculectomy, risk factors for failure and the preoperative state of the conjunctiva. J Glaucoma. 2001;10:237–49.

    Article  PubMed  CAS  Google Scholar 

  5. Kitazawa Y, Kawase K, Matsushita H, Minobe M. Trabeculectomy with mitomycin. A comparative study with fluorouracil. Arch Ophthalmol. 1991;109:1693–8.

    Article  PubMed  CAS  Google Scholar 

  6. The Advanced Glaucoma Intervention Study (AGIS): 11. Risk factors for failure of trabeculectomy and argon laser trabeculoplasty. Am J Ophthalmol. 2002;134:481–98.

    Google Scholar 

  7. Mills KB. Trabeculectomy: a retrospective long-term follow-up of 444 cases. Br J Ophthalmol. 1981;65:790–5.

    Article  PubMed  CAS  Google Scholar 

  8. Allen RC, Bellows AR, Hutchinson BT, Murphy SD. Filtration surgery in the treatment of neovascular glaucoma. Ophthalmology. 1982;89:1181–7.

    PubMed  CAS  Google Scholar 

  9. Katz LJ, Spaeth GL. Surgical management of the secondary glaucomas: part I. Ophthalmic Surg. 1987;18:826–34.

    PubMed  CAS  Google Scholar 

  10. Heuer DK, Gressel MG, Parrish RK 2nd, Anderson DR, Hodapp E, Palmberg PF. Trabeculectomy in aphakic eyes. Ophthalmology. 1984;91:1045–51.

    PubMed  CAS  Google Scholar 

  11. Law SK, Shih K, Tran DH, Coleman AL, Caprioli J. Long-term outcomes of repeat vs initial trabeculectomy in open-angle glaucoma. Am J Ophthalmol. 2009;148(685–95):e1.

    PubMed  Google Scholar 

  12. Beauchamp GR, Parks MM. Filtering surgery in children: barrier to success. Ophthalmology. 1979;86:170–80.

    PubMed  CAS  Google Scholar 

  13. Cadera W, Pachtman MA, Cantor LB, Ellis FD, Helveston EM. Filtering surgery in childhood glaucoma. Ophthalmic Surg. 1984;15:584–90.

    Google Scholar 

Download references

Acknowledgments

This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Tokyo, Japan, and from the Ministry of Health, Labor and Welfare, Tokyo, Japan.

Author information

Authors and Affiliations

  1. Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan

    Toshihiro Inoue, Masaru Inatani, Yuji Takihara, Nanako Awai-Kasaoka, Minako Ogata-Iwao & Hidenobu Tanihara

Authors
  1. Toshihiro Inoue
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masaru Inatani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yuji Takihara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nanako Awai-Kasaoka
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Minako Ogata-Iwao
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hidenobu Tanihara
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Toshihiro Inoue.

About this article

Cite this article

Inoue, T., Inatani, M., Takihara, Y. et al. Prognostic risk factors for failure of trabeculectomy with mitomycin C after vitrectomy. Jpn J Ophthalmol 56, 464–469 (2012). https://doi.org/10.1007/s10384-012-0171-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10384-012-0171-2

Keywords

Search

Navigation