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The usefulness of infraorbital nerve enlargement on MRI imaging in clinical diagnosis of IgG4-related orbital disease

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the frequency of infraorbital nerve enlargement (IONE) in orbital lymphoproliferative disorders, and to show that IONE can contribute to the clinical diagnosis of IgG4-related orbital diseases (IgG4-ROD).

Subjects and methods

71 cases in which orbital lymphoproliferative disorders were diagnosed at Okayama Medical Center and Mitoyo General Hospital from April, 2004 to March, 2011 were investigated. The male-to-female ratio was 39:32, and the age range 27–87 years old (average age 64.1 years). Whenever the coronal section of the infraorbital nerve was larger than that of the optic nerve on MRI, it was defined as IONE.

Results

The breakdown of the 71 cases was: 45 cases of non-Hodgkin lymphoma, 16 cases of IgG4-ROD, 5 cases of reactive lymphoid hyperplasia, and 5 cases of idiopathic orbital inflammation. Of these, a total of 9 cases had IONE. The incidence of IONE was compared between the IgG4-ROD patient group and the non-IgG4-ROD patient group and was significantly higher in the IgG4-ROD patient group (p < 0.0001).

Conclusion

If IONE is observed in a case of orbital lymphoproliferative disorders on MRI, then it is highly possible that such a case is IgG4-ROD.

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Author information

Authors and Affiliations

  1. Section of Ophthalmology, National Hospital Organization Okayama Medical Center, 1711-1 Tamasu, Kitaku, Okayama, 701-1154, Japan

    Koh-ichi Ohshima

  2. Section of Ophthalmology, Mitoyo General Hospital, Kanonji, Japan

    Yuka Sogabe

  3. Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Yasuharu Sato

Authors
  1. Koh-ichi Ohshima
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  2. Yuka Sogabe
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  3. Yasuharu Sato
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Corresponding author

Correspondence to Koh-ichi Ohshima.

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Ohshima, Ki., Sogabe, Y. & Sato, Y. The usefulness of infraorbital nerve enlargement on MRI imaging in clinical diagnosis of IgG4-related orbital disease. Jpn J Ophthalmol 56, 380–382 (2012). https://doi.org/10.1007/s10384-012-0151-6

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  • DOI: https://doi.org/10.1007/s10384-012-0151-6

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