Abstract
Purpose
To establish a Korean normative database of retinal nerve fiber layer (RNFL) thickness.
Methods
Data was collected from 103 healthy volunteers. Total ophthalmologic examinations, including fast RNFL thickness analysis by time domain optical coherence tomography (STRATUS OCT) were performed. The RNFL thickness of 64 glaucoma patients with localized RNFL defects and 48 independent healthy subjects were collected. The RNFL thickness of both the glaucoma patients and the healthy subjects was evaluated using both normative databases.
Results
The average RNFL thickness of Koreans was 108.3 ± 10.3 μm. The sensitivity rates recorded in the Korean normative database with 5% and 1% significance were 0.984 and 0.984, with specificity values of 0.938 and 1.000. By comparison, the sensitivity rates in the conventional normative database with 5% and 1% significance are 0.984 and 0.953, and the specificity values are 1.000 and 1.000.
Conclusion
In detecting localized RNFL defects, the Korean database showed higher sensitivity than the conventional database.
Similar content being viewed by others
References
Quigley HA, Addicks EM, Green R. Optic nerve damage in human glaucoma. III: Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic optic neuropathy, papilledema, and toxic neuropathy. Arch Ophthalmol 1982;100:135–146.
Mikelberg FS, Yidegiligne HM, Shulzer M. Optic nerve axon count and axon diameter in patients with ocular hypertension and normal visual fields. Ophthalmology 1995;102:342–348.
Mardin CY, Junemann AG. The diagnostic value of optic nerve imaging in early glaucoma. Curr Opin Ophthalmol 2001;12:100–104.
Quigley HA, Miller NR, George T. Clinical evaluation of nerve fiber atrophy as an indicator of glaucomatous optic nerve damage. Arch Ophthalmol 1980;98:1564–1571.
Quigley HA, Addicks EM. Quantitative studies of retinal nerve fiber layer defects. Arch Ophthalmol 1982;100:807–814.
Sommer A, Miller NR, Pollack I, et al. The nerve fiber layer in the diagnosis of glaucoma. Arch Ophthalmol 1977;95:2149–2156.
Tuulonen A, Lehtola J, Airaksinen PJ. Nerve fiber layer defects with normal visual fields: do normal optic disc and normal visual field indicate absence of glaucomatous abnormality? Ophthalmology 1993;100:587–598.
Jeoung JW, Park KH, Kim TW, et al. Diagnostic ability of optical coherence tomography with a normative database to detect localized retinal nerve fiber layer defects. Ophthalmology 2005;112:2157–2163.
Sihota R, Sony P, Gupta V, et al. Diagnostic capability of optical coherence tomography in evaluating the degree of glaucomatous retinal nerve fiber damage. Invest Ophthalmol Vis Sci 2006;47:2006–2010.
Kim TW, Park UC, Park KH, et al. Ability of Stratus OCT to identify localized retinal nerve fiber layer defects in patients with normal standard automated perimetry results. Invest Ophthalmol Vis Sci 2007;48:1635–1641.
Lee EJ, Kim TW, Park KH, et al. Ability of Stratus OCT to detect progressive retinal nerve fiber layer atrophy in glaucoma. Invest Ophthalmol Vis Sci 2009;50:662–668.
Budenz D, Michael A, Chang R, et al. Sensitivity and specificity of the stratus OCT for perimetric glaucoma. Ophthalmology 2005;112:3–9.
Mandavi KN, Hoffman D, Tannenbaum DP, et al. Identifying early glaucoma with optical coherence tomography. Am J Ophthalmol 2004;137:228–235.
Bowd C, Zangwill LM, Berry CC, et al. Detecting early glaucoma by assessment of retinal nerve fiber layer thickness and visual function. Invest Ophthalmol Vis Sci 2001;42:1993–2003.
Patella M. STRATUS OCT: establishment of normative reference values for retinal nerve fiber layer thickness measurements. Carl Zeiss Meditec, Inc. Dublin, CA.
Wilson MR, Eezzuduemhoi DR. Ophthalmologic disorders in minority populations. Med Clin North Am 2005;89:795–804.
Aung T, Nolan WP, Machin D, et al. Anterior chamber depth and the risk of primary open angle closure in 2 East Asian populations. 2005;123:527–532.
Wadhwa SD, Higginbotham EJ. Ethnic differences in glaucoma: prevalence, management, and outcome. Curr Opin Ophthalmol 2005;16:101–106.
Nagasubramanian S, Weale RA. Ethnic variability of the vasculature of the optic disc in normal tension and in glaucomatous eyes. Eur J Ophthalmol 2004;14:501–507.
Friedman DS, West SK, Munoz B, et al. Racial variations in cause of vision loss in nursing homes: The Salisbury eye evaluation in nursing home groups (SEEING) study. Arch Ophthalmol 2004;122:1019–1024.
Poinoosawmy D, Fontana L, Xu JX, et al. Variation of nerve fiber layer thickness measurement with age and ethnicity by scanning laser polarimetry. Br J Ophthalmol 1997;81:350–354.
Varma R, Bazzaz S, Lai M. Optical tomography-measured retinal nerve fiber layer thickness in normal Latinos. Invest Ophthalmol Vis Sci 2003;44:3369–3373.
Racette L, Boden C, Kleinhandler SL, et al. Differences in visual function and optic nerve structure between healthy eyes of blacks and whites. Arch Ophthalmol 2005;123:1547–1553.
Mok KH, Lee VW, So KF. Retinal nerve fiber layer measurement of the Hong Kong Chinese population by optical coherence tomography. J Glaucoma 2002;11:481–483.
Lee JB, Cho YS, Chae YJ, et al. The prevalence of glaucoma in Korean adults. J Korean Ophthalmol Soc 1993;34:65–69.
Sommer A, Quigley HA, Robin AL, et al. Evaluation of nerve fiber layer assessment. Arch Ophthalmol 1984;102:1766–1771.
Quigley HA, Miller NR, George T. Clinical evaluation of nerve fiber layer atrophy as an indicator of glaucomatous optic nerve damage. Arch Ophthalmol 1980;98:1564–1571.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Kang, S.H., Park, K.H., Kim, J.M. et al. Korean normative database for time domain optical coherence tomography to detect localized retinal nerve fiber layer defects (preliminary study). Jpn J Ophthalmol 54, 144–150 (2010). https://doi.org/10.1007/s10384-009-0777-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10384-009-0777-1