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Photodynamic therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy: A 30-month multicenter study in Hyogo, Japan

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the long-term effects of photodynamic therapy (PDT) on different phenotypes of age-related macular degeneration (AMD): typical AMD (tAMD) and polypoidal choroidal vasculopathy (PCV).

Methods

A multicenter prospective study of 207 eyes of 201 patients (tAMD, 123 eyes; PCV, 84 eyes) treated with PDT. Sex, age, best-corrected visual acuity (BCVA), greatest linear dimension, and lesion type were evaluated for pretreatment factors. PDT frequency, BCVA at 30 months post-PDT, frequency of recurrence, and mean recurrence period were compared as posttreatment outcomes.

Results

The 30 months post-PDT mean BCVA was significantly lower than the pre-PDT value in the tAMD group, but it remained unchanged in the PCV group. There was no difference in PDT frequency between the two groups. Multivariate analysis revealed that lesion type was the only predicting factor significantly associated with BCVA at 30 months post-PDT. The incidence of recurrence before 30 months post-PDT was not significantly different between the tAMD and PCV groups, whereas the mean duration of the PDT effect was significantly longer in the PCV group than in the tAMD group.

Conclusions

PDT may have some advantages for PCV patients, but not for tAMD patients. However, as PCV often recurred 12 months post-PDT, long-term observation after the treatment is crucial.

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Author information

Authors and Affiliations

  1. Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan

    Shigeru Honda

  2. Department of Ophthalmology, Kobe City General Hospital, Kobe, Japan

    Yasuo Kurimoto

  3. Department of Ophthalmology, Ono Municipal Hospital, Ono, Japan

    Yasuaki Kagotani

  4. Department of Ophthalmology, Nippon Steel Hirohata Hospital, Himeji, Japan

    Hiroyuki Yamamoto

  5. Department of Ophthalmology, Hyogo Prefectural Amagasaki Hospital, Amagasaki, Japan

    Hitoshi Takagi

  6. Department of Ophthalmology, Mitsubishi Kobe Hospital, Kobe, Japan

    Mamoru Uenishi

  7. Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Shigeru Honda

Authors
  1. Shigeru Honda
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  2. Yasuo Kurimoto
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  3. Yasuaki Kagotani
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  4. Hiroyuki Yamamoto
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  5. Hitoshi Takagi
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  6. Mamoru Uenishi
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for the Hyogo Macular Disease Study Group

Corresponding author

Correspondence to Shigeru Honda.

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Honda, S., Kurimoto, Y., Kagotani, Y. et al. Photodynamic therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy: A 30-month multicenter study in Hyogo, Japan. Jpn J Ophthalmol 53, 593–597 (2009). https://doi.org/10.1007/s10384-009-0741-0

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  • DOI: https://doi.org/10.1007/s10384-009-0741-0

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