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Tear film osmolarity in patients with thyroid ophthalmopathy

  • Laboratory Investigation
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Abstract

Purpose

To compare tear film osmolarity between patients with thyroid ophthalmopathy and normal healthy subjects.

Methods

The tear film osmolarity in 15 normal subjects (15 eyes) (control group) and 21 patients (21 eyes) with thyroid ophthalmopathy was evaluated. Tear film osmolarity in milliosmole (mOsm) was determined by using an auto-osmometer. The palpebral fissure width, degree of proptosis, and tear break-up time (BUT) were also determined. The results for the two groups were compared statistically.

Results

The mean palpebral fissure width was 9.13 ± 0.74 mm in the healthy subjects and 13.33 ± 1.55 mm in the thyroid ophthalmopathy patients. This difference was statistically significant (P = 0.0001). The mean proptosis was 15.33 ± 1.39 Hertel units in the healthy subjects and 20.71 ± 0.95 Hertel units in the patients. This difference was also statistically significant (P = 0.0001). The mean tear BUT was 6.35 ± 1.56 s in the patients and 18.27 ± 1.53 s in the healthy subjects, and this difference was also statistically significant (P = 0.0005). The mean tear film osmolarity was 290.80 ± 13.58 mOsm in the healthy subjects and 340.38 ± 18.74 mOsm in the patients. There was a statistically significant difference between the groups (P = 0.0001).

Conclusions

The significantly higher tear film osmolarity in patients with thyroid ophthalmopathy was most likely due to the increased proptosis and lid fissure width. These conditions may lead to injury of the ocular surface.

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References

  1. Kanski JJ. Disorder of the orbit. In: Clinical Ophthalmology, a Systematic Approach. 4th ed. Oxford: Butterworth Heinemann; 1999. p. 558–563.

    Google Scholar 

  2. Tucker SM, Tucker NA, Linberg JV. Thyroid eye disease. In: Tasman W, Jaeger EA, editors. Duane’s clinical ophthalmology. Philadelphia: Lippincott-Raven; 1998. p. 1–19.

    Google Scholar 

  3. Lemp MA. Report of the National Eye Institute/Industry Workshop on clinical trials in dry eyes. CLAO J 1995;21:221–232.

    CAS  PubMed  Google Scholar 

  4. Gilbard JP, Farris RL. Ocular surface drying and tear film osmolarity in thyroid eye disease. Acta Ophthalmol (Copenh) 1983;61: 108–116.

    Article  CAS  Google Scholar 

  5. Luo L, Li DQ, Doshi A, Farley W, Corrales RM, Pflugfelder SC. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci 2004;45:4293–4301.

    Article  PubMed  Google Scholar 

  6. Gilbard JP, Rossi SR, Gray Heyda K. Ophthalmic solutions, the ocular surface, and a unique therapeutic artificial tear formulation. Am J Ophthalmol 1989;107:348–355.

    Article  CAS  PubMed  Google Scholar 

  7. Croci T, Landi M, Gully D, Maffrand JP, Le Fur G, Manara L. Negative modulation of nitric oxide production by neurotensin as a putative mechanism of the diuretic action of SR 48692 in rats. Br J Pharmacol 1997;120:1312–1318.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Rossato M, Balercia G, Lucarelli G, Foresta C, Mantero F. Role of seminal osmolarity in the reduction of human sperm motility. Int J Androl 2002;25:230–235.

    Article  CAS  PubMed  Google Scholar 

  9. Ray CD. Clinical pathology and clinical chemistry. In: Ray CD, editor. Medical engineering. Chicago: Year Book Medical; 1974. p. 43–782.

    Google Scholar 

  10. Paschides CA, Kitsios G, Karakostas KX, Psillas C, Moutsopoulos HM. Evaluation of tear break-up time, Schirmer’s-I test and rose bengal staining as confirmatory tests for keratoconjunctivitis sicca. Clin Exp Rheumatol 1989;7:155–157.

    CAS  PubMed  Google Scholar 

  11. Von Bahr G. Könnte die Flussigkeitsabgang durch die Cornea von physiologischer Bedeutung sein. Acta Opthalmol (Copenh) 1941;19:125–134.

    Article  Google Scholar 

  12. Gulati A, Dana R. Keratoconjunctivitis Sicca: Clinic aspects. In: Foster CS, Azar DT, Dohlman CH, editors. Smolin and Thoft’s the cornea. Philadelphia: Lippincott-Williams & Wilkins; 2005. p. 603–627.

    Google Scholar 

  13. Rolando M, Refojo MF, Kenyon KR. Increased tear evaporation in eyes with keratoconjunctivitis sicca. Arch Ophthalmol 1983;101:557–558.

    Article  CAS  PubMed  Google Scholar 

  14. Luo L, Li DQ, Corrales RM, Pflugfelder SC. Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye & Contact Lens 2005;31:186–193.

    Article  Google Scholar 

  15. Katsuyama I, Arakawa T. A convenient rabbit model of ocular epithelium damage induced by osmotic dehydration. J Ocul Pharmacol Ther 2003;19:281–289.

    Article  CAS  PubMed  Google Scholar 

  16. Gilbard JP, Carter JB, Sang DN, et al. Morphologic effect of hyperosmolarity on rabbit corneal epithelium. Ophthalmology 1984;91:1205–1212.

    Article  CAS  PubMed  Google Scholar 

  17. Nowak M, Marek B, Kos-Kudla B, Kajdaniuk D, Sieminska L. Tear film profile in patients with active thyroid orbithopathy. Klin Oczna 2005;107:479–482.

    PubMed  Google Scholar 

  18. Khurana AK, Sunder S, Ahluwalia BK, Malhotra KC. Tear film profile in Graves ophthalmopathy. Acta Ophthalmol (Copenh) 1992;70:346–349.

    Article  CAS  Google Scholar 

  19. McCulley JP, Uchiyama E, Aronowicz JD, Butovich IA. Impact of evaporation on aqueous tear loss. Trans Am Ophthalmol Soc 2006;104:121–128.

    PubMed  PubMed Central  Google Scholar 

  20. Tsubota K, Nakamori K. Dry eyes and video display terminals. N Eng J Med 1993;328:584.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Cerrahpasa Faculty of Medicine, Department of Ophthalmology, Istanbul University, Istanbul, Turkey

    Guzin Iskeleli & Arzu Abdula

  2. Faculty of Medicine, Department of Physiology, Inonu University, Malatya, Turkey

    Yunus Karakoc

Authors
  1. Guzin Iskeleli
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  2. Yunus Karakoc
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  3. Arzu Abdula
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Corresponding author

Correspondence to Guzin Iskeleli.

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Iskeleli, G., Karakoc, Y. & Abdula, A. Tear film osmolarity in patients with thyroid ophthalmopathy. Jpn J Ophthalmol 52, 323–326 (2008). https://doi.org/10.1007/s10384-008-0545-7

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  • DOI: https://doi.org/10.1007/s10384-008-0545-7

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