Summary
Focal palmar hyperhidrosis is a common and often debilitating eccrine sweat gland disorder with negative impact on quality of life and self-esteem. For treatment of recalcitrant cases, a stellate ganglion block is a nonsurgical alternative. Although this method has only a temporary effect, surgical risks can be avoided. The usual way to perform the block is by ultrasound-guided injection of local anesthetics. Here we describe the use of therapeutic ultrasound at 0.8 MHz for stellate ganglion block. Ultrasound was applied for 1 min unilaterally every other day for 6 days. The efficacy was monitored by video capillaroscopy and Minor’s iodine starch test. Treatment was well tolerated and no adverse effects were noted. Sweating was stopped and capillary blood flow increased. The effect lasted for several weeks.
Zusammenfassung
Die fokale palmare Hyperhidrose ist eine häufige und oftmals hinderliche Erkrankung der ekkrinen Schweißdrüsen mit negativen Auswirkungen auf die Lebensqualität und das Selbstwertgefühl. Für therapieresistente Fälle stellt die Stellatum-Blockade eine nicht-chirurgische Alternative dar. Obwohl die Wirkung zeitlich begrenzt ist, können chirurgische Risiken vermieden werden. Wir beschreiben die Verwendung von therapeutischem 0,8 MHz-Ultraschall für eine Stellatum-Blockade. Der Ultraschall wurde für eine Minute unilateral jeden zweiten Tag für insgesamt sechs Tage eingesetzt. Die Effizienz wurde durch Video-Kapillaroskopie und den Minor-Test objektiviert. Die Behandlung wurde gut vertragen, unerwünschte Nebenwirkungen traten nicht auf. Das übermäßige Schwitzen wurde gestoppt und der kapilläre Blutfluß gesteigert. Die Wirkung hielt einige Wochen an.
Similar content being viewed by others
References
Strutton DR, Kowalski JW, Glaser DA, Stang PE. US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: results from a national survey. J Am Acad Dermatol. 2004;51(2):241–8.
Westphal FL, Carvalho MA de, Lima LC, Carvalho BC de, Padilla R, Araújo KK. Prevalence of hyperhidrosis among medical students. Rev Col Bras Cir. 2011;38(6):392–7.
Lima SO, Aragão JF, Machado Neto J, Almeida KB, Menezes LM, Santana VR. Research of primary hyperhidrosis in students of medicine of the State of Sergipe, Brazil. An Bras Dermatol. 2015;90(5):661–5.
Schlereth T, Dieterich M, Birklein F. Hyperhidrosis – causes and treatment of enhanced sweating. Dtsch Arztebl Int. 2009;106(3):32–7.
Du Q, Lin M, Yang JH, Chen JF, Tu YR. Overexpression of AQP5 was detected in axillary sweat glands of primary focal hyperhidrosis patients. Dermatology. 2016;232(2):150–5.
Nejsum LN, Kwon TH, Jensen UB, Fumagalli O, Frøkiaer J, Krane CM, Menon AG, King LS, Agre PC, Nielsen S. Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Proc Natl Acad Sci U S A. 2002;99(1):511–6.
Inoue R, Sohara E, Rai T, Satoh T, Yokozeki H, Sasaki S, Uchida S. Immunolocalization and translocation of aquaporin-5 water channel in sweat glands. J Dermatol Sci. 2013;70(1):26–33.
Bragança GM, Lima SO, Pinto NAF, Marques LM, Melo EV, Reis FP. Evaluation of anxiety and depression prevalence in patients with primary severe hyperhidrosis. An Bras Dermatol. 2014;89(2):230–5.
Kouris A, Armyra K, Stefanaki C, Christodoulou C, Karimali P, Kontochristopoulos G. Quality of life and social isolation in Greek adolescents with primary focal hyperhidrosis treated with botulinum toxin type A: a case series. Pediatr Dermatol. 2015;32(2):226–30.
Pariser DM, Ballard A. Topical therapies in hyperhidrosis care. Dermatol Clin. 2014;32(4):485–90.
Wollina U. Botulinum toxin: non-cosmetic indications and possible mechanisms of action. J Cutan Aesthet Surg. 2008;1(1):3–6.
Wollina U, Uhlemann C, Elstermann D, Köber L, Barta U. Therapy of hyperhidrosis with tap water iontophoresis. Positive effect on healing time and lack of recurrence in hand-foot eczema. Hautarzt. 1998;49(2):109–13.
Hölzle E. Tap water iontophoresis. Hautarzt. 2012;63(6):462–8.
Hund M, Sinkgraven R, Rzany B. Randomized, placebo-controlled, double blind clinical trial for the evaluation of the efficacy and safety of oral methantheliniumbromide (Vagantin) in the treatment of focal hyperhidrosis. J Dtsch Dermatol Ges. 2004;2(5):343–9.
Walling HW. Systemic therapy for primary hyperhidrosis: a retrospective study of 59 patients treated with glycopyrrolate or clonidine. J Am Acad Dermatol. 2012;66(3):387–92.
Raposio E, Caruana G. Video-assisted thoracic sympathicotomy for the treatment of palmar and axillary hyperhidrosis: a 17-year experience. Surg Laparosc Endosc Percutan Tech. 2015;25(5):417–9.
Karamustafaoglu YA, Kuzucuoglu M, Yanik F, Sagiroglu G, Yoruk Y. 3‑year follow-up after uniportal thoracoscopic sympathicotomy for hyperhidrosis: undesirable side effects. J Laparoendosc Adv Surg Tech A. 2014;24(11):782–5.
Menna C, Ibrahim M, Andreetti C, Ciccone AM, D’Andrilli A, Maurizi G, Poggi C, Rendina EA. Long term compensatory sweating results after sympathectomy for palmar and axillary hyperhidrosis. Ann Cardiothorac Surg. 2016;5(1):26–32.
Minor V. Ein neues Verfahren zu der klinischen Untersuchung der Schweißabsonderung. Dtsch Z Nervenheilkd. 1928;101(1):302–7.
Wörle B, Heckmann M, Rapprich S. Definition und Therapie der primären Hyperhidrose, AWMF-Register-Nr. 013059. http://www.awmf.org/uploads/tx_szleitlinien/013-059l_S1_prim%C3%A4re_Hyperhidrose_Definition_Therapie_2012-01.pdf. Accessed 12 Feb 2016.
Edel H. Fibel der Elektrodiagnostik und Elektrotherapie, 5th ed. Berlin: Volk und Gesundheit; 1983.
Dosch P. Lehrbuch der Neuraltherapie nach Huneke (Regulationstherapie mit Lokalanästhetika), 12th ed. Heidelberg: Haug; 1986.
Pangratis N. Diagnostic investigation using vital capillary microscopy and dynamic capillaroscopy. Clin Hemorheol Microcirc. 1997;17(5):371–83.
Cheshire WP, Fealey RD. Drug-induced hyperhidrosis and hypohidrosis: incidence, prevention and management. Drug Saf. 2008;31(2):109–26.
Di Sciascio G, Riva MA. Aripiprazole: from pharmacological profile to clinical use. Neuropsychiatr Dis Treat. 2015;11:2635–47. doi:10.2147/NDT.S88117.
Lu BY, Cullen CE, Eide CE, Williams CC, Apfeldorf WJ. Antidepressant-induced sweating alleviated by aripiprazole. J Clin Psychopharmacol. 2008;28(6):710–1.
Huang WL, Chang LR. Hyperhidrosis under combination of zotepine and haloperidol alleviated by aripiprazole. Psychiatry Clin Neurosci. 2012;66(3):245.
Lessa LR, Luz FB, De Rezende RM, Durães SM, Harrison BJ, De Menezes GB, Fontenelle LF. The psychiatric facet of hyperhidrosis: demographics, disability, quality of life, and associated psychopathology. J Psychiatr Pract. 2014;20(4):316–23.
Bale R. Ganglion block. When and how? Radiologe. 2015;55(10):886–95.
Fujiwara S, Komasawa N, Kido H, Minami T. A rare case of accidental arterial local anesthetic injection under ultrasound-guided stellate ganglion block. J Clin Anesth. 2016;29:3–4.
Shankar H, Simhan S. Transient neuronal injury followed by intravascular injection during an ultrasound guided stellate ganglion block. Anesth Pain Med. 2013;2(3):134–7.
Crandall CG, Meyer DM, Davis SL, Dellaria SM. Palmar skin blood flow and temperature responses throughout endoscopic sympathectomy. Anesth Analg. 2005;100(1):277–83.
Yang SH, Tsai JC, Kao MC. Laser Doppler scanning study of palmar skin perfusion for patients with hyperhidrosis before and after thoracic sympathectomy. Surg Neurol. 2006;66(Suppl 2):S48–51.
Ng I, Yeo TT. Palmar hyperhidrosis: intraoperative monitoring with laser Doppler blood flow as a guide for success after endoscopic thoracic sympathectomy. Neurosurgery. 2003;52(1):127–30.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
B. Heinig, A. Koch, and U. Wollina declare that they have no competing interests.
Rights and permissions
About this article
Cite this article
Heinig, B., Koch, A. & Wollina, U. Palmar hyperhidrosis treated by noninvasive ultrasound stellate ganglion block. Wien Med Wochenschr 168, 250–253 (2018). https://doi.org/10.1007/s10354-016-0468-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10354-016-0468-8