Zusammenfassung
Die Spondylitis ankylosans (AS) ist eine Autoimmunerkrankung und gehört zur Gruppe der seronegativen Spondylarthropathien. Sie ist mit dem HLA B27 assoziiert und betrifft in erster Linie die Wirbelsäule und die Sakroiliakalgelenke, kann aber auch die peripheren Gelenke sowie diverse Organe befallen. Die Erkrankung betrifft vor allem Männer und geht mit Morgensteifigkeit und dumpfem Rückenschmerz einher, die sich durch Bewegung bessern. AS führt zu einer verminderten Lebenserwartung, eine möglichst frühzeitige Diagnose und Therapie sind daher sehr wichtig.
Summary
Ankylosing Spondylitis (AS) is an autoimmune disease of unknown cause belonging to the group of spondyloarthritides associated with HLA B27. This disease affects the spine and sacroiliac joints, but may also concern peripheral joints and different organs. Symptoms include morning stiffness and dull low back pain, both improving by exercise. AS causes reduction in life expectancy due to subsequent manifestation in different organs, so early diagnosis and treatment are of great importance.
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References
Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH. Rheumatology. 4th Ed. Mosby-Elsevier, Philadelphia. Section 9: Spondylarthropathies, pp 2056, 2008. (text with continually updated online reference, 2-volume set, ISBN 9780323044295)
Taurog JD. The Spondyloarthritides (Section II, Chapter 8). In: Fauci AS, Langford C (ed) Harrison's Rheumatology. 16th Ed. McGraw-Hill Professional, 2006
Moll J, Haslock I, MacRae IF, Wright V. Association between ankylosing spondylitis, psoriatic arthritis, Reiter's disease, the intestinal arthropathies and Behcet's syndrome. Medicine, 53: 343–364, 1974
Van Der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for Ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum, 27: 361–368, 1984
Müller-Ladner U. Chapter 5: Spondylitis ankylosans. In: Evidenzbasierte Therapie in der Rheumatologie (Evidence based Therapy in Rheumatology). Uni-Med Verlag, Bremen-London-Boston, 2005
Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A. A new approach to defining disease status in Ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol, 21: 2286–2291, 1994
Calin A, Garrett S, Whitelock H, et al. A new approach to defining functional ability in Ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol, 21: 2281–2285, 1994
Van Der Heijde D, Bellamy N, Calin A, Dougados M, Khan MA, Van Der Linden S. Preliminary core sets for endpoints in Ankylosing spondylitis. Assessments in Ankylosing Spondylitis Working Group. J Rheumatol, 24: 2225–2229, 1997
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Wolf, J., Fasching, P. Ankylosing spondylitis. Wien Med Wochenschr 160, 211–214 (2010). https://doi.org/10.1007/s10354-010-0793-2
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DOI: https://doi.org/10.1007/s10354-010-0793-2