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Decreased Expression of Monocyte Chemoattractant Protein-1 Predicts Poor Prognosis Following Curative Resection of Colorectal Cancer

  • Original Contribution
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Diseases of the Colon & Rectum

Abstract

Purpose

The significance of monocyte chemoattractant protein-1 in colorectal cancer is not well understood. The aim of this study was to investigate the significance of monocyte chemoattractant protein-1 expression in colorectal cancer patients undergoing potentially curative surgery.

Methods

We studied 101 colorectal cancer patients who underwent potentially curative surgery. The concentration of monocyte chemoattractant protein-1 in the tumor and normal mucosa were measured. The expression of monocyte chemoattractant protein-1 was also evaluated immunohistochemically.

Results

The tissue concentration of monocyte chemoattractant protein-1 in the tumor was significantly higher than that in the normal mucosa. The decreased monocyte chemoattractant protein-1 cancer/normal ratio was associated with lymph node involvement and could predict poor prognosis. On univariate analysis, the decreased monocyte chemoattractant protein-1 ratio, carcinoembryonic antigen levels, and serosal invasion were the significant factors for poor prognosis. Multivariate analysis showed that monocyte chemoattractant protein-1 ratio was the only independent risk factor predictive of a poor prognosis. Immunohistochemically, monocyte chemoattractant protein-1 was expressed in the cytoplasm.

Conclusion

The decreased monocyte chemoattractant protein-1 ratio was an independent factor predicting poor prognosis in patients undergoing potentially curative surgery. Monocyte chemoattractant protein-1 deficiency may present a new therapeutic approach for colorectal cancer.

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Authors and Affiliations

  1. Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan

    Hideki Watanabe M.D., Chikao Miki M.D., Yoshinaga Okugawa M.D., Yuji Toiyama M.D., Yasuhiro Inoue M.D. & Masato Kusunoki M.D.

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  1. Hideki Watanabe M.D.
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  2. Chikao Miki M.D.
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  3. Yoshinaga Okugawa M.D.
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  4. Yuji Toiyama M.D.
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  5. Yasuhiro Inoue M.D.
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  6. Masato Kusunoki M.D.
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Correspondence to Hideki Watanabe M.D..

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Watanabe, H., Miki, C., Okugawa, Y. et al. Decreased Expression of Monocyte Chemoattractant Protein-1 Predicts Poor Prognosis Following Curative Resection of Colorectal Cancer. Dis Colon Rectum 51, 1800–1805 (2008). https://doi.org/10.1007/s10350-008-9380-7

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  • DOI: https://doi.org/10.1007/s10350-008-9380-7

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