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Temporary Sacral Nerve Stimulation for Treatment of Irritable Bowel Syndrome: A Pilot Study

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Diseases of the Colon & Rectum

Abstract

Purpose

This study was designed to evaluate the effect of temporary sacral nerve stimulation in patients with diarrhea-predominant irritable bowel syndrome.

Methods

Symptoms of diarrhea-predominant irritable bowel syndrome and disease-specific quality of life was evaluated in six patients before and during percutaneous sacral nerve evaluation test. Primary end points were differences between total irritable bowel syndrome symptom score and total quality of life score before and during stimulation. Secondary end points were differences between the variable domains.

Results

Percutaneous sacral nerve evaluation test was performed in five women and one man (median age, 33 (range, 26–54) years). The irritable bowel syndrome symptom score decreased from 48.9 to 28.3 (P = 0.004). Pain, bloating, and diarrhea were significantly reduced from 7.9, 13.5, and 17.3 to 4.4, 7.2, and 10.6, respectively (P = 0.02, P = 0.01, P = 0.03). The irritable bowel syndrome quality of life score decreased from 99.3 to 59.6 (P = 0.009). Daily activities, emotional distress, eating habits, and fatigue were significantly reduced from 26.9, 22.2, 15.2, and 23.2 to 16.9, 13.3, 8, and 14.4, respectively (P = 0.02, P = 0.02, P = 0.02, P = 0.007). Two weeks after cessation of stimulation, the patients had symptoms as before stimulation.

Conclusions

Temporary sacral nerve stimulation provides a significant reduction in diarrhea-predominant irritable bowel symptoms and improves quality of life. Further studies with permanent implantation and double-blind crossover ON-and-OFF-stimulation to evaluate the impact of placebo effect are needed.

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Authors and Affiliations

  1. Department of Surgery P and Neurogastroenterology Unit, Aarhus University Hospital, Aarhus, Denmark

    Lilli Lundby M.D., Ph.D., Steen Buntzen M.D., D.M.Sc. & Søren Laurberg M.D., D.M.Sc.

  2. Department of Hepatology and Gastroenterology V, Aarhus University Hospital, Aarhus, Denmark

    Klaus Krogh M.D., D.M.Sc.

  3. Department of Surgery P, Aarhus University Hospital, Section TGH, Tage Hansensgade 2, DK-8000, Aarhus C, Denmark

    Lilli Lundby M.D., Ph.D.

Authors
  1. Lilli Lundby M.D., Ph.D.
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  2. Klaus Krogh M.D., D.M.Sc.
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  3. Steen Buntzen M.D., D.M.Sc.
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  4. Søren Laurberg M.D., D.M.Sc.
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Correspondence to Lilli Lundby M.D., Ph.D..

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Lundby, L., Krogh, K., Buntzen, S. et al. Temporary Sacral Nerve Stimulation for Treatment of Irritable Bowel Syndrome: A Pilot Study. Dis Colon Rectum 51, 1074–1078 (2008). https://doi.org/10.1007/s10350-008-9255-y

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  • DOI: https://doi.org/10.1007/s10350-008-9255-y

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