Purpose
This study was designed to analyze the results of a multimodality treatment using preoperative radiotherapy, followed by surgery and intraoperative radiotherapy in patients with primary locally advanced rectal cancer.
Methods
Between 1987 and 2002, 123 patients with initial unresectable and locally advanced rectal cancer were identified in our prospective database, containing patient characteristics, radiotherapy plans, operation notes, histopathologic reports, and follow-up details. An evaluation of prognostic factors for local recurrence, distant metastases, and overall survival was performed.
Results
All patients were treated preoperatively with a median dose of 50 Gy radiotherapy. Surgery was performed six to ten weeks after radiotherapy. Twenty-seven patients were treated with intraoperative radiotherapy because margins were incomplete or ≤2 mm. Postoperative mortality was 2 percent. The median follow-up of all patients was 25.1 months. The overall five-year local control was 65 percent and the overall five-year survival was 50 percent. Positive lymph nodes and incomplete resections negatively influenced local control and overall survival. Intraoperative radiotherapy improved five-year local control (58 vs. 0 percent, P = 0.016) and overall survival (38 vs. 0 percent, P = 0.026) for patients with R1/2 resections.
Conclusions
The presented multimodality treatment is feasible with an acceptable mortality and a five-year overall survival of 50 percent. Addition of intraoperative radiotherapy for patients with a narrow or microscopic incomplete resection seems to overrule the unfavorable prognostic histologic finding.
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References
LL Gunderson MJ O’Connell RR Dozois (1992) ArticleTitleThe role of intra-operative irradiation in locally advanced primary and recurrent rectal adenocarcinoma World J Surg 16 495–501 Occurrence Handle1589987 Occurrence Handle1:STN:280:By2B2s7ltlA%3D Occurrence Handle10.1007/BF02104454
E Kapiteijn CA Marijnen ID Nagtegaal et al. (2001) ArticleTitlePreoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer N Engl J Med 345 638–646 Occurrence Handle11547717 Occurrence Handle1:STN:280:DC%2BD3Mvps1ektw%3D%3D Occurrence Handle10.1056/NEJMoa010580
RJ Heald BJ Moran RD Ryall R Sexton JK MacFarlane (1998) ArticleTitleRectal cancer: the Basingstoke experience of total mesorectal excision, 1978–1997 Arch Surg 133 894–899 Occurrence Handle9711965 Occurrence Handle1:STN:280:DyaK1cznsFOrsQ%3D%3D Occurrence Handle10.1001/archsurg.133.8.894
E Kapiteijn CA Marijnen AC Colenbrander et al. (1998) ArticleTitleLocal recurrence in patients with rectal cancer diagnosed between 1988 and 1992: a population-based study in the west Netherlands Eur J Surg Oncol 24 528–535 Occurrence Handle9870729 Occurrence Handle1:STN:280:DyaK1M%2Fos1aktA%3D%3D Occurrence Handle10.1016/S0748-7983(98)93500-4
Anonymous. Randomised trial of surgery alone versus surgery followed by radiotherapy for mobile cancer of the rectum. Medical Research Council Rectal Cancer Working Party. Lancet 1996;348:1610–4.
M Vermaas FT Ferenschild JJ Nuyttens et al. (2005) ArticleTitlePreoperative radiotherapy improves outcome in recurrent rectal cancer Dis Colon Rectum 48 918–928 Occurrence Handle15785886 Occurrence Handle10.1007/s10350-004-0891-6
CG Willett PC Shellito JE Tepper R Eliseo K Convery WC Wood (1991) ArticleTitleIntraoperative electron beam radiation therapy for primary locally advanced rectal and rectosigmoid carcinoma J Clin Oncol 9 843–849 Occurrence Handle2016628 Occurrence Handle1:STN:280:By6B3c3itFY%3D
L Pahlman B Glimelius (1992) ArticleTitlePre-operative and post-operative radiotherapy and rectal cancer World J Surg 16 858–865 Occurrence Handle1462620 Occurrence Handle1:STN:280:ByyD1MjntFM%3D Occurrence Handle10.1007/BF02066982
GJ Frykholm B Glimelius L Pahlman (1993) ArticleTitlePreoperative or postoperative irradiation in adenocarcinoma of the rectum: final treatment results of a randomized trial and an evaluation of late secondary effects Dis Colon Rectum 36 564–572 Occurrence Handle8500374 Occurrence Handle1:STN:280:ByyB2s3mtFM%3D Occurrence Handle10.1007/BF02049863
JJ Nuyttens IK Kolkman-Deurloo M Vermaas et al. (2004) ArticleTitleHigh-dose-rate intraoperative radiotherapy for close or positive margins in patients with locally advanced or recurrent rectal cancer Int J Radiat Oncol Biol Phys 58 106–112 Occurrence Handle14697427 Occurrence Handle10.1016/S0360-3016(03)01494-9
MJ Eble T Lehnert C Herfarth M Wannenmacher (1998) ArticleTitleIntraoperative radiotherapy as adjuvant treatment for stage II/III rectal carcinoma Recent Results Cancer Res 146 152–160 Occurrence Handle9670258 Occurrence Handle1:STN:280:DyaK1czjsV2itg%3D%3D
IK Kolkman-Deurloo JJ Nuyttens PE Hanssens PC Levendag (2004) ArticleTitleIntraoperative HDR brachytherapy for rectal cancer using a flexible intraoperative template: standard plans versus individual planning Radiother Oncol 70 75–79 Occurrence Handle15036855 Occurrence Handle10.1016/j.radonc.2003.10.010
ES Kaplan (1958) ArticleTitleNonparametric estimation from incomplete observations J Am Stat Assoc 53 457–481 Occurrence Handle10.2307/2281868
DR Cox (1972) ArticleTitleRegression models and life tables J R Stat Soc B34 187–220
GH Mannaerts HJ Rutten H Martijn GJ Groen PE Hanssens T Wiggers (2001) ArticleTitleAbdominosacral resection for primary irresectable and locally recurrent rectal cancer Dis Colon Rectum 44 806–814 Occurrence Handle11391140 Occurrence Handle1:STN:280:DC%2BD3Mzkt1Cgug%3D%3D Occurrence Handle10.1007/BF02234699
E Bussieres FN Gilly P Rouanet et al. (1996) ArticleTitleRecurrences of rectal cancers: results of a multimodal approach with intraoperative radiation therapy. French Group of IORT. Intraoperative Radiation Therapy Int J Radiat Oncol Biol Phys 34 49–56 Occurrence Handle12125680 Occurrence Handle1:STN:280:DC%2BD38znvFyrsw%3D%3D Occurrence Handle10.1016/0360-3016(95)02048-9
LL Gunderson MG Haddock H Nelson et al. (1997) ArticleTitleLocally recurrent colorectal cancer: IOERT and EBRT ±5-FU and maximal resection Front Radiat Ther Oncol 31 224–228 Occurrence Handle9263828 Occurrence Handle1:STN:280:ByiH3cbks1M%3D
D Hahnloser H Nelson LL Gunderson et al. (2003) ArticleTitleCurative potential of multimodality therapy for locally recurrent rectal cancer Ann Surg 237 502–508 Occurrence Handle12677146 Occurrence Handle10.1097/00000658-200304000-00011
CG Willett PC Shellito JE Tepper R Eliseo K Convery WC Wood (1991) ArticleTitleIntraoperative electron beam radiation therapy for recurrent locally advanced rectal or rectosigmoid carcinoma Cancer 67 1504–1508 Occurrence Handle2001537 Occurrence Handle1:STN:280:By6C2MbptFM%3D Occurrence Handle10.1002/1097-0142(19910315)67:6<1504::AID-CNCR2820670607>3.0.CO;2-X
M Vermaas FT Ferenschild JJ Nuyttens et al. (2005) ArticleTitlePreoperative radiotherapy improves outcome in recurrent rectal cancer Dis Colon Rectum 48 918–928 Occurrence Handle15785886 Occurrence Handle10.1007/s10350-004-0891-6
GH Mannaerts H Martijn MA Crommelin W Dries OJ Repelaer van Driel HJ Rutten (2000) ArticleTitleFeasibility and first results of multimodality treatment, combining EBRT, extensive surgery, and IOERT in locally advanced primary rectal cancer Int J Radiat Oncol Biol Phys 47 425–433 Occurrence Handle10802370 Occurrence Handle1:STN:280:DC%2BD3c3mtlyhug%3D%3D Occurrence Handle10.1016/S0360-3016(99)00492-7
BM Nakfoor CG Willett PC Shellito DS Kaufman WJ Daly (1998) ArticleTitleThe impact of 5-fluorouracil and intraoperative electron beam radiation therapy on the outcome of patients with locally advanced primary rectal and rectosigmoid cancer Ann Surg 228 194–200 Occurrence Handle9712564 Occurrence Handle1:STN:280:DyaK1czns1Cjuw%3D%3D Occurrence Handle10.1097/00000658-199808000-00008
G Palmer A Martling L Blomqvist B Cedermark T Holm (2005) ArticleTitleOutcome after the introduction of a multimodality treatment program for locally advanced rectal cancer Eur J Surg Oncol 31 727–734 Occurrence Handle15979271 Occurrence Handle1:STN:280:DC%2BD2MvlvVCgsA%3D%3D Occurrence Handle10.1016/j.ejso.2005.04.009
ID Nagtegaal CA Marijnen EK Kranenbarg CJ Velde Particlevan de JH Krieken Particlevan (2002) ArticleTitleCircumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma: not one millimeter but two millimeters is the limit Am J Surg Pathol 26 350–357 Occurrence Handle11859207 Occurrence Handle10.1097/00000478-200203000-00009
Vermaas M, Ferenschild FT, Nuyttens JJ, et al. Total pelvic exenteration for primary locally advanced and recurrent rectal cancer. Eur J Surg Oncol 2006; (in press).
GJ Frykholm L Pahlman B Glimelius (1995) ArticleTitleTreatment of local recurrences of rectal carcinoma Radiother Oncol 34 185–194 Occurrence Handle7543209 Occurrence Handle1:STN:280:ByqA2MjltVU%3D Occurrence Handle10.1016/0167-8140(95)01519-M
W Neve ParticleDe H Martijn MM Lybeert M Crommelin C Goor JG Ribot (1991) ArticleTitleIncompletely resected rectum, recto-sigmoid, or sigmoid carcinoma: results of postoperative radiotherapy and prognostic factors Int J Radiat Oncol Biol Phys 21 1297–1302 Occurrence Handle1938527
I Azinovic FA Calvo F Puebla J Aristu R Martinez-Monge (2001) ArticleTitleLong-term normal tissue effects of intraoperative electron radiation therapy (IOERT): late sequelae, tumor recurrence, and second malignancies Int J Radiat Oncol Biol Phys 49 597–604 Occurrence Handle11173160 Occurrence Handle1:STN:280:DC%2BD3M7kvFGqtQ%3D%3D Occurrence Handle10.1016/S0360-3016(00)01475-9
HK Kim JM Jessup CJ Beard et al. (1997) ArticleTitleLocally advanced rectal carcinoma: pelvic control and morbidity following preoperative radiation therapy, resection, and intraoperative radiation therapy Int J Radiat Oncol Biol Phys 38 777–783 Occurrence Handle9240646 Occurrence Handle1:STN:280:ByiA1c3msVY%3D Occurrence Handle10.1016/S0360-3016(97)89476-X
JN Wiig JP Poulsen KM Tveit DR Olsen KE Giercksky (2000) ArticleTitleIntra-operative irradiation (IORT) for primary advanced and recurrent rectal cancer. a need for randomised studies Eur J Cancer 36 868–874 Occurrence Handle10785591 Occurrence Handle1:STN:280:DC%2BD3c3kvFSjuw%3D%3D Occurrence Handle10.1016/S0959-8049(00)00015-0
FA Calvo M Gomez-Espi JA Diaz-Gonzalez et al. (2002) ArticleTitleIntraoperative presacral electron boost following preoperative chemoradiation in T3-4Nx rectal cancer: initial local effects and clinical outcome analysis Radiother Oncol 62 201–206 Occurrence Handle11937247 Occurrence Handle10.1016/S0167-8140(01)00477-7
CG Willett (2001) ArticleTitleIntraoperative radiation therapy Int J Clin Oncol 6 209–214 Occurrence Handle11723741 Occurrence Handle1:STN:280:DC%2BD3MnnvVequg%3D%3D Occurrence Handle10.1007/PL00012107
LL Gunderson H Nelson JA Martenson et al. (1997) ArticleTitleLocally advanced primary colorectal cancer: intraoperative electron and external beam irradiation ±5-FU Int J Radiat Oncol Biol Phys 37 601–614 Occurrence Handle9112459 Occurrence Handle1:STN:280:ByiB28nntlI%3D Occurrence Handle10.1016/S0360-3016(96)00563-9
D Hahnloser MG Haddock H Nelson (2003) ArticleTitleIntraoperative radiotherapy in the multimodality approach to colorectal cancer Surg Oncol Clin N Am 12 993–1013 Occurrence Handle14989129 Occurrence Handle10.1016/S1055-3207(03)00091-7
A Wibe MT Eriksen A Syse S Tretli HE Myrvold O Soreide (2005) ArticleTitleEffect of hospital caseload on long-term outcome after standardization of rectal cancer surgery at a national level Br J Surg 92 217–224 Occurrence Handle15584060 Occurrence Handle1:STN:280:DC%2BD2M7hslOquw%3D%3D Occurrence Handle10.1002/bjs.4821
D Schrag KS Panageas E Riedel et al. (2002) ArticleTitleHospital and surgeon procedure volume as predictors of outcome following rectal cancer resection Ann Surg 236 583–592 Occurrence Handle12409664 Occurrence Handle10.1097/00000658-200211000-00008
CB Begg LD Cramer WJ Hoskins MF Brennan (1998) ArticleTitleImpact of hospital volume on operative mortality for major cancer surgery JAMA 280 1747–1751 Occurrence Handle9842949 Occurrence Handle1:STN:280:DyaK1M%2FlslSrsQ%3D%3D Occurrence Handle10.1001/jama.280.20.1747
AS Allal S Bieri MA Brundler et al. (2002) ArticleTitlePreoperative hyperfractionated radiotherapy for locally advanced rectal cancers: a phase I–II trial Int J Radiat Oncol Biol Phys 54 1076–1081 Occurrence Handle12419434 Occurrence Handle10.1016/S0360-3016(02)03003-1
AM Cohen BD Minsky (1990) ArticleTitleAggressive surgical management of locally advanced primary and recurrent rectal cancer. Current status and future directions Dis Colon Rectum 33 432–438 Occurrence Handle2183979 Occurrence Handle1:STN:280:By%2BB38fhtV0%3D Occurrence Handle10.1007/BF02156274
BD Minsky AM Cohen WE Enker et al. (1997) ArticleTitlePreoperative 5-FU, low-dose leucovorin, and radiation therapy for locally advanced and unresectable rectal cancer Int J Radiat Oncol Biol Phys 37 289–295 Occurrence Handle9069299 Occurrence Handle1:CAS:528:DyaK2sXisVeitLY%3D Occurrence Handle10.1016/S0360-3016(96)00487-7
MJ O’Connell JA Martenson HS Wieand et al. (1994) ArticleTitleImproving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery N Engl J Med 331 502–507 Occurrence Handle8041415 Occurrence Handle1:STN:280:ByuA3MnisFU%3D Occurrence Handle10.1056/NEJM199408253310803
JF Bosset G Calais A Daban et al. (2004) ArticleTitlePreoperative chemoradiotherapy versus preoperative radiotherapy in rectal cancer patients: assessment of acute toxicity and treatment compliance. Report of the 22921 randomised trial conducted by the EORTC Radiotherapy Group Eur J Cancer 40 219–224 Occurrence Handle14728936 Occurrence Handle1:STN:280:DC%2BD2c%2FivFentg%3D%3D Occurrence Handle10.1016/j.ejca.2003.09.032
JF Bosset (2005) ArticleTitleRectal cancer: preoperative chemoradiation, a new standard [in French] Cancer Radiother 9 137–139 Occurrence Handle15967700 Occurrence Handle1:STN:280:DC%2BD2MvhtFKquw%3D%3D
R Sauer H Becker W Hohenberger et al. (2004) ArticleTitlePreoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med 351 1731–1740 Occurrence Handle15496622 Occurrence Handle1:CAS:528:DC%2BD2cXovFSksbo%3D Occurrence Handle10.1056/NEJMoa040694
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Ferenschild, F.T.J., Vermaas, M., Nuyttens, J.J.M.E. et al. Value of Intraoperative Radiotherapy in Locally Advanced Rectal Cancer. Dis Colon Rectum 49, 1257–1265 (2006). https://doi.org/10.1007/s10350-006-0651-x
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DOI: https://doi.org/10.1007/s10350-006-0651-x