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Long-Term Results of “Chemical Sphincterotomy” for Chronic Anal Fissure: A Prospective Study

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Diseases of the Colon & Rectum

Introduction

Pharmacologic anal sphincter relaxants promote fissure healing; however, their effect is transient and the risk of late recurrence remains uncertain.

Methods

From August 1997 to August 2002, patients with chronic anal fissure attending our outpatient clinic were treated with a protocol that included: topical isosorbide dinitrate, 2.5 mg, or nifedipine, 0.2 percent t.i.d., or the combination of both. Botulinum toxin 20 units was injected to the internal anal sphincter to those who failed. All the patients were contacted and interviewed during November to December 2002.

Results

Follow-up was a median of 47.43 ± 13 (range, 4.7–60) months. A total of 455 patients completed the study; 323 patients (71 percent) healed at follow-up ending: 170 of the healed patients had one or more recurrences that responded to further treatment (37.4 percent), whereas 153 patients (33.6 percent) healed and had no recurrences. One hundred thirty-two patients (29 percent) did not heal and were referred to lateral sphincterotomy. Long intervals between symptoms appearance and treatment initiation decreased healing and increased recurrence rates (P = 0.03 and 0.01 respectively).

Conclusions

Topical treatment is effective for patients with chronic anal fissure, at short-term and long-term periods. Because for many patients it is not a definitive treatment, it can be offered to those who are ready to receive repeated treatments. Longer intervals between symptom appearance and treatment initiation negatively affects fissure healing and recurrence rate.

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Authors and Affiliations

  1. Gastroenterology Service, Division of Medicine, Hadassah University Hospital and Hebrew University Medical School, Jerusalem, Israel

    Joseph Lysy M.D., Eran Israeli M.D., Sharon Levy M.D., Gloria Rozentzweig C.N., Nourit Strauss-Liviatan M.A. & Eran Goldin M.D.

  2. Department of Gastroenterology, Hadassah University Hospital, PO Box 12000, Jerusalem, 91120, Israel

    Eran Goldin M.D.

Authors
  1. Joseph Lysy M.D.
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  2. Eran Israeli M.D.
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  3. Sharon Levy M.D.
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  4. Gloria Rozentzweig C.N.
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  5. Nourit Strauss-Liviatan M.A.
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  6. Eran Goldin M.D.
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Correspondence to Eran Goldin M.D..

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Lysy, J., Israeli, E., Levy, S. et al. Long-Term Results of “Chemical Sphincterotomy” for Chronic Anal Fissure: A Prospective Study. Dis Colon Rectum 49, 858–864 (2006). https://doi.org/10.1007/s10350-006-0510-9

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  • DOI: https://doi.org/10.1007/s10350-006-0510-9

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