Skip to main content
SpringerLink
Log in

Gene Expression Profiling of Nonneoplastic Mucosa May Predict Clinical Outcome of Colon Cancer Patients

  • Original Contribution
  • Published:
Diseases of the Colon & Rectum

PURPOSE

This study assessed the possibility to build a prognosis predictor, based on microarray gene expression measures, in Stage II and III colon cancer patients.

METHODS

Tumor and nonneoplastic mucosa mRNA samples from 12 colon cancer patients were profiled using the Affymetrix HGU133A GeneChip. Six of 12 patients experienced a metachronous metastasis, whereas the 6 others remained disease-free for more than five years. Three datasets were constituted, including, respectively, the gene expression measures in tumor samples (T), in adjacent nonneoplastic mucosa samples (A), and the log-ratio of the gene expression measures (L). The step-down procedure of Westfall and Young and the k-nearest neighbor class prediction method were applied on T, A, and L. Leave-one-out cross-validation was used to estimate the generalization error of predictors based on different numbers of genes and neighbors.

RESULTS

The most frequent results were one false prediction with the A-based predictors (95 percent) and two false predictions with the T- and l-based predictors (65 and 60 percent, respectively). A-based predictors were more stable (i.e., less sensitive to changes of parameters, such as numbers of genes and neighbors) than T- and l-based predictors. Informative genes in A-based predictors included genes involved in the oxidative and phosphorylative mitochondrial metabolism and genes involved in cell-signaling pathways and their receptors.

CONCLUSIONS

This study suggests that one can build a prognosis predictor for Stage II and III colon cancer patients, based on microarray gene expression measures, and suggests the potential usefulness of nonneoplastic mucosa for this purpose.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

REFERENCES

  1. Fleming ID, Cooper JS, Henson DE, et al. AJCC: cancer staging manual. 5th ed. Philadelphia: Lippincott-Raven, 1997

  2. CG Moertel TR Fleming JS MacDonald et al. (1990) ArticleTitleLevamisole and fluorouracil as adjuvant therapy of resected colon carcinoma N Engl J Med 322 352–8 Occurrence Handle2300087 Occurrence Handle1:STN:280:DyaK3c7js1Ohsw%3D%3D Occurrence Handle10.1056/NEJM199002083220602

    Article  PubMed  CAS  Google Scholar 

  3. N Wolmark H Rockette B Fisher et al. (1993) ArticleTitleThe benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: results from National Surgical Adjuvant Breast and Bowel Project protocol C-03 J Clin Oncol 11 1879–87 Occurrence Handle8410113 Occurrence Handle1:STN:280:DyaK2c%2FhsFajtw%3D%3D

    PubMed  CAS  Google Scholar 

  4. International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT) Investigators. Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. Lancet 1995;345:939–44.

    Google Scholar 

  5. MJ O'Connell JA Mailliard MJ Kahn et al. (1997) ArticleTitleControlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer J Clin Oncol 15 246–50 Occurrence Handle8996149

    PubMed  Google Scholar 

  6. N Wolmark H Rockette E Mamounas et al. (1999) ArticleTitleClinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon. Results from National Surgical Adjuvant Breast and Bowel Project C-04 J Clin Oncol 17 3553–9 Occurrence Handle10550154 Occurrence Handle1:CAS:528:DyaK1MXnvVGltLo%3D

    PubMed  CAS  Google Scholar 

  7. MJ O'Connell JA Laurie M Kahn et al. (1998) ArticleTitleProspectively randomized trial of postoperative adjuvant chemotherapy in patients with high-risk colon cancer J Clin Oncol 16 295–300 Occurrence Handle9440756

    PubMed  Google Scholar 

  8. HC Moore DG Haller (1999) ArticleTitleAdjuvant therapy of colon cancer Semin Oncol 26 545–55 Occurrence Handle10528903 Occurrence Handle1:CAS:528:DyaK1MXntFOktbw%3D

    PubMed  CAS  Google Scholar 

  9. A Zaniboni (1997) ArticleTitleAdjuvant chemotherapy in colorectal cancer with high-dose leucovorin and fluorouracil: impact on disease-free survival and overall survival J Clin Oncol 15 2432–41 Occurrence Handle9196159 Occurrence Handle1:CAS:528:DyaK2sXkt1ersbo%3D

    PubMed  CAS  Google Scholar 

  10. T Andre C Boni L Mounedji-Boudiaf et al. (2004) ArticleTitleOxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer N Engl J Med 350 2343–51 Occurrence Handle15175436 Occurrence Handle10.1056/NEJMoa032709 Occurrence Handle1:CAS:528:DC%2BD2cXks1Gjt78%3D

    Article  PubMed  CAS  Google Scholar 

  11. International Multicenter Pooled Analysis of B2 Colon Cancer Trials (IMPACT B2) Investigators. Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer. J Clin Oncol 1999;17:1356-63

    Google Scholar 

  12. E Mamounas S Wieand N Wolmark et al. (1999) ArticleTitleComparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer. Results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04) J Clin Oncol 17 1349–55 Occurrence Handle10334518 Occurrence Handle1:STN:280:DyaK1M3msFKrtQ%3D%3D

    PubMed  CAS  Google Scholar 

  13. S Gill CL Loprinzi DJ Sargent et al. (2004) ArticleTitlePooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: who benefits and by how much? J Clin Oncol 22 1797–806 Occurrence Handle15067028 Occurrence Handle10.1200/JCO.2004.09.059 Occurrence Handle1:CAS:528:DC%2BD2cXptlClu7Y%3D

    Article  PubMed  CAS  Google Scholar 

  14. KC Halling AJ French SK McDonnell et al. (1999) ArticleTitleMicrosatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers J Natl Cancer Inst 91 1295–303 Occurrence Handle10433618 Occurrence Handle10.1093/jnci/91.15.1295 Occurrence Handle1:CAS:528:DyaK1MXlsFyltbc%3D

    Article  PubMed  CAS  Google Scholar 

  15. R Gryfe H Kim ET Hsieh et al. (2000) ArticleTitleTumor satellite instability and clinical outcome in young patients with colorectal cancer N Engl J Med 342 69–77 Occurrence Handle10631274 Occurrence Handle10.1056/NEJM200001133420201 Occurrence Handle1:STN:280:DC%2BD3c%2FotVeitA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  16. N Hawkins M Norrie K Cheong et al. (2002) ArticleTitleCpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability Gastroenterology 122 1376–87 Occurrence Handle11984524 Occurrence Handle10.1053/gast.2002.32997 Occurrence Handle1:CAS:528:DC%2BD38Xkt1Cru7s%3D

    Article  PubMed  CAS  Google Scholar 

  17. C Wang M Rijnsoever Particlevan F Grieu et al. (2003) ArticleTitlePrognostic significance of microsatellite instability and Ki-ras mutation type in stage II colorectal cancer Oncology 64 259–65 Occurrence Handle12697967 Occurrence Handle10.1159/000069311 Occurrence Handle1:CAS:528:DC%2BD3sXivFOhtrc%3D

    Article  PubMed  CAS  Google Scholar 

  18. TE Witzig CL Loprinzi NJ Gonchoroff et al. (1991) ArticleTitleDNA ploidy and cell kinetic measurements as predictors of recurrence and survival in stages B2 and C colorectal adenocarcinoma Cancer 68 879–88 Occurrence Handle1855188 Occurrence Handle10.1002/1097-0142(19910815)68:4<879::AID-CNCR2820680434>3.0.CO;2-4 Occurrence Handle1:STN:280:DyaK3MzgvFSgtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  19. MA Chapman JD Hardcastle NC Armitage (1995) ArticleTitleFive-year prospective study of DNA tumor ploidy and colorectal cancer survival Cancer 76 383–7 Occurrence Handle8625117 Occurrence Handle10.1002/1097-0142(19950801)76:3<383::AID-CNCR2820760306>3.0.CO;2-F Occurrence Handle1:STN:280:DyaK283itlSnsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  20. E Martinez-Lopez A Abad A Font et al. (1998) ArticleTitleAllelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer Gastroenterology 114 1180–7 Occurrence Handle9609754 Occurrence Handle10.1016/S0016-5085(98)70423-8 Occurrence Handle1:STN:280:DyaK1c3ot1emtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  21. W Zhou SN Goodman G Galizia et al. (2002) ArticleTitleCounting alleles to predict recurrence of early-stage colorectal cancers Lancet 359 219–25 Occurrence Handle11812558 Occurrence Handle10.1016/S0140-6736(02)07448-2

    Article  PubMed  Google Scholar 

  22. HL McLeod GI Murray (1999) ArticleTitleTumor markers of prognosis in colorectal cancer Br J Cancer 79 191–203 Occurrence Handle9888457 Occurrence Handle1:STN:280:DyaK1M7gtlGgsA%3D%3D

    PubMed  CAS  Google Scholar 

  23. D Shibata MA Reale P Lavin et al. (1996) ArticleTitleThe DCC protein and prognosis in colorectal cancer N Engl J Med 335 1727–32 Occurrence Handle8929264 Occurrence Handle10.1056/NEJM199612053352303 Occurrence Handle1:STN:280:DyaK2s%2Fnt1Wgug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  24. OA Ogunbiyi PJ Goodfellow K Herfarth et al. (1998) ArticleTitleConfirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator J Clin Oncol 16 427–33 Occurrence Handle9469325 Occurrence Handle1:STN:280:DyaK1c7ivFahtQ%3D%3D

    PubMed  CAS  Google Scholar 

  25. XF Sun S Rutten H Zhang et al. (1999) ArticleTitleExpression of the deleted in colorectal cancer gene is related to prognosis in DNA diploid and low proliferative colorectal adenocarcinoma J Clin Oncol 17 1745–50 Occurrence Handle10561211 Occurrence Handle1:STN:280:DC%2BD3c%2FivF2nsg%3D%3D

    PubMed  CAS  Google Scholar 

  26. W Zhou G Galizia E Lieto et al. (2001) ArticleTitleCounting alleles reveals a connection between chromosome 18q loss and vascular invasion Nat Biotechnol 19 78–81 Occurrence Handle11135558 Occurrence Handle10.1038/86777 Occurrence Handle1:CAS:528:DC%2BD3MXis1Smtr4%3D

    Article  PubMed  CAS  Google Scholar 

  27. LJ Vant Veer H Dai MJ Vijver ParticleVan de et al. (2002) ArticleTitleGene expression profiling predicts clinical outcome of breast cancer Nature 415 530–6 Occurrence Handle10.1038/415530a Occurrence Handle1:CAS:528:DC%2BD38Xht1Giu7k%3D

    Article  CAS  Google Scholar 

  28. MJ Vijver ParticleVan de DH Yudong LJ Vant Veer et al. (2002) ArticleTitleA gene-expression signature as a predictor of survival in breast cancer N Engl J Med 347 1999–2009 Occurrence Handle12490681 Occurrence Handle10.1056/NEJMoa021967

    Article  PubMed  Google Scholar 

  29. DG Beer SLR Kardia C Huang et al. (2002) ArticleTitleGene expression profiles predict survival of patients with lung adenocarcinoma Nat Med 8 816–24 Occurrence Handle12118244 Occurrence Handle1:CAS:528:DC%2BD38Xls12msLk%3D

    PubMed  CAS  Google Scholar 

  30. A Bhattacharjee WG Richards J Staunton et al. (2001) ArticleTitleClassification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses Proc Natl Acad Sci USA 98 13790–5 Occurrence Handle11707567 Occurrence Handle10.1073/pnas.191502998 Occurrence Handle1:CAS:528:DC%2BD3MXovVynt7s%3D

    Article  PubMed  CAS  Google Scholar 

  31. MA Shipp KN Ross P Tamayo et al. (2002) ArticleTitleDiffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning Nat Med 8 68–74 Occurrence Handle11786909 Occurrence Handle10.1038/nm0102-68 Occurrence Handle1:CAS:528:DC%2BD38XjtlygsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  32. A Rosenwald G Wright WC Chan et al. (2002) ArticleTitleThe use of molecular profiling to predict survival after chemotherapy for diffuse large B-cell lymphoma N Engl J Med 346 1937–47 Occurrence Handle12075054 Occurrence Handle10.1056/NEJMoa012914

    Article  PubMed  Google Scholar 

  33. CM Fredericksen S Knudsen S Laurberg TF Orntoft (2003) ArticleTitleClassification of Dukes' B and C colorectal cancers using expression arrays J Cancer Res Clin Oncol 129 263–71

    Google Scholar 

  34. K Birkenkamp-Demtroder LL Christensen SH Olesen et al. (2002) ArticleTitleGene expression in colorectal cancer Cancer Res 62 4352–63 Occurrence Handle12154040 Occurrence Handle1:CAS:528:DC%2BD38XlvFeluro%3D

    PubMed  CAS  Google Scholar 

  35. F Bertucci S Salas S Eysterier et al. (2004) ArticleTitleGene expression profiling of colon cancer and correlation with histoclinical parameters Oncogene 23 1377–91 Occurrence Handle14973550 Occurrence Handle10.1038/sj.onc.1207262 Occurrence Handle1:CAS:528:DC%2BD2cXhtlKhuro%3D

    Article  PubMed  CAS  Google Scholar 

  36. B Iacopetta (2002) ArticleTitleAre there two sides to colorectal cancer? Int J Cancer 101 403–8 Occurrence Handle12216066 Occurrence Handle10.1002/ijc.10635 Occurrence Handle1:CAS:528:DC%2BD38Xnt1ehsrw%3D

    Article  PubMed  CAS  Google Scholar 

  37. U Alon N Barkai DA Notterman et al. (1999) ArticleTitleBroad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays Proc Natl Acad Sci USA 96 6745–50 Occurrence Handle10359783 Occurrence Handle10.1073/pnas.96.12.6745 Occurrence Handle1:CAS:528:DyaK1MXks1WksL4%3D

    Article  PubMed  CAS  Google Scholar 

  38. S Backert M Gelos U Kobalz et al. (1999) ArticleTitleDifferential gene expression in colon carcinoma cells and tissues detected with a cDNA array Int J Cancer 82 868–74 Occurrence Handle10446455 Occurrence Handle10.1002/(SICI)1097-0215(19990909)82:6<868::AID-IJC16>3.0.CO;2-W Occurrence Handle1:CAS:528:DyaK1MXlvVKiu7k%3D

    Article  PubMed  CAS  Google Scholar 

  39. P Hedge R Qi R Gaspard et al. (2001) ArticleTitleIdentification of tumor markers in models of human colorectal cancer using a 19,200-element complementary DNA microarray Cancer Res 61 7792–7

    Google Scholar 

  40. O Kitahara Y Furukawa T Tanaka et al. (2001) ArticleTitleAlterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser-capture microdissection of tumor tissues and normal epithelia Cancer Res 61 3544–9 Occurrence Handle11325815 Occurrence Handle1:CAS:528:DC%2BD3MXjsFCgt7g%3D

    PubMed  CAS  Google Scholar 

  41. DA Notterman U Alon AJ Sierk AJ Levine (2001) ArticleTitleTranscriptional gene expression profiles of colorectal adenoma, adenocarcinoma and normal tissue examined by oligonucleotide arrays Cancer Res 61 3124–30 Occurrence Handle11306497 Occurrence Handle1:CAS:528:DC%2BD3MXivFGqsb8%3D

    PubMed  CAS  Google Scholar 

  42. D Agrawal T Chen R Irby et al. (2002) ArticleTitleOsteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling J Natl Cancer Inst 94 513–21 Occurrence Handle11929952 Occurrence Handle1:CAS:528:DC%2BD38Xjt1Ciurw%3D

    PubMed  CAS  Google Scholar 

  43. YM Lin Y Furukawa T Tsunoda CT Yue KC Yang Y Nakamura (2002) ArticleTitleMolecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas Oncogene 21 4120–8 Occurrence Handle12037668 Occurrence Handle10.1038/sj.onc.1205518 Occurrence Handle1:CAS:528:DC%2BD38XltVymtb0%3D

    Article  PubMed  CAS  Google Scholar 

  44. TT Zou FM Selaru Y Xu et al. (2002) ArticleTitleApplication of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon Oncogene 21 4855–62 Occurrence Handle12101425 Occurrence Handle10.1038/sj.onc.1205613 Occurrence Handle1:CAS:528:DC%2BD38XltVOmu7k%3D

    Article  PubMed  CAS  Google Scholar 

  45. O Tureci J Ding H Hilton et al. (2003) ArticleTitleComputational dissection of tissue contamination for identification of colon cancer-specific expression profiles FASEB J 17 376–85 Occurrence Handle12631577 Occurrence Handle10.1096/fj.02-0478com Occurrence Handle1:CAS:528:DC%2BD3sXitFeiur8%3D

    Article  PubMed  CAS  Google Scholar 

  46. NS Williams RB Gaynor S Scoggin et al. (2003) ArticleTitleIdentification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference Clin Cancer Res 9 931–46 Occurrence Handle12631590 Occurrence Handle1:CAS:528:DC%2BD3sXhvFKiurs%3D

    PubMed  CAS  Google Scholar 

  47. Y Wang T Jatkoe Y Zhang et al. (2004) ArticleTitleGene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer J Clin Oncol 27 1564–71 Occurrence Handle10.1200/JCO.2004.08.186 Occurrence Handle1:CAS:528:DC%2BD2cXpsVWmurw%3D

    Article  CAS  Google Scholar 

  48. RA Irizarry B Hobbs F Collin et al. (2003) ArticleTitleExploration, normalization, and summaries of high density oligonucleotide array probe level data Biostatistics 4 249–64 Occurrence Handle12925520 Occurrence Handle10.1093/biostatistics/4.2.249

    Article  PubMed  Google Scholar 

  49. BM Bolstad RA Irizarry M Astrand TP Speed (2003) ArticleTitleA comparison of normalization methods for high density oligonucleotide array based on variance and bias Bioinformatics 19 185–93 Occurrence Handle12538238 Occurrence Handle10.1093/bioinformatics/19.2.185 Occurrence Handle1:CAS:528:DC%2BD3sXitlCnsL4%3D

    Article  PubMed  CAS  Google Scholar 

  50. Westfall PH, Young SS. Resampling-based multiple testing: examples and methods for p-value adjustment. New York: John Wiley £ Sons, 1993

  51. MJ Laan ParticleVan der S Dudoit KS Pollard (2004) ArticleTitleMultiple testing. Part II. Step-down procedures for control of the family-wise error rate Stat Appl Genet Mol Biol 3 14

    Google Scholar 

  52. S Dudoit JP Shaffer JC Boldrick (2003) ArticleTitleMultiple hypothesis testing in microarray experiments Stat Sci 18 71–103 Occurrence Handle10.1214/ss/1056397487

    Article  Google Scholar 

  53. Dudoit S, Fridlyand J. Classification in microarray experiments. In: Speed T, ed. Statistical analysis of gene expression microarray data. Boca Raton: Chapman £ Hall/CRC, 2003:93–158

  54. L Breiman (1996) ArticleTitleHeuristics of instability and stabilization in model selection Ann Stat 24 2350–83 Occurrence Handle10.1214/aos/1032181158

    Article  Google Scholar 

  55. M West C Blanchette H Dressman et al. (2001) ArticleTitlePredicting the clinical status of human breast cancer by using gene expression profiles Proc Natl Acad Sci USA 98 11462–7 Occurrence Handle11562467 Occurrence Handle10.1073/pnas.201162998 Occurrence Handle1:CAS:528:DC%2BD3MXnt1yqu7w%3D

    Article  PubMed  CAS  Google Scholar 

  56. C Ambroise GJ McLachlan (2002) ArticleTitleSelection bias in gene extraction on the basis of microarray gene-expression data Proc Natl Acad Sci USA 99 6562–6 Occurrence Handle11983868 Occurrence Handle10.1073/pnas.102102699 Occurrence Handle1:CAS:528:DC%2BD38XjvFCktbo%3D

    Article  PubMed  CAS  Google Scholar 

  57. MM Mueller NE Fusenig (2004) ArticleTitleFriends or foes—bipolar effects of the tumour stroma in cancer Nat Rev Cancer 4 839–49 Occurrence Handle15516957 Occurrence Handle10.1038/nrc1477 Occurrence Handle1:CAS:528:DC%2BD2cXptFegt78%3D

    Article  PubMed  CAS  Google Scholar 

  58. MD Sternlicht A Lochter CJ Sympson et al. (1999) ArticleTitleThe stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis Cell 98 137–46 Occurrence Handle10428026 Occurrence Handle10.1016/S0092-8674(00)81009-0 Occurrence Handle1:CAS:528:DyaK1MXltVOqt7o%3D

    Article  PubMed  CAS  Google Scholar 

  59. NA Bhowmick A Chytil D Plieth et al. (2004) ArticleTitleTGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia Science 303 848–51 Occurrence Handle14764882 Occurrence Handle10.1126/science.1090922 Occurrence Handle1:CAS:528:DC%2BD2cXovVKmtQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  60. LC Chen CY Hao YS Chiu et al. (2004) ArticleTitleAlteration of gene expression in normal-appearing colon mucosa of APC(min) mice and human cancer patients Cancer Res 64 3694–700 Occurrence Handle15150130 Occurrence Handle10.1158/0008-5472.CAN-03-3264 Occurrence Handle1:CAS:528:DC%2BD2cXktVWht7o%3D

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service de Chirurgie Digestive, Hôpital Tenon, Université Pierre et Marie Curie, Assistance Publique, Paris, France

    Alain Barrier M.D., François Lacaine M.D., Sidney Houry M.D. & Michel Huguier M.D.

  2. INSERM U444, Faculté de Médecine Saint-Antoine, Université Pierre et Marie Curie, Paris, France

    Alain Barrier M.D., Pierre-Yves Boelle Ph.D. & Antoine Flahault M.D., Ph.D.

  3. Division of Biostatistics, School of Public Health, University of California, Berkeley, California, France

    Alain Barrier M.D. & Sandrine Dudoit Ph.D.

  4. INSERM U602, Hôpital Paul Brousse, Université Paris XI, Villejuif, France

    Antoinette Lemoine Ph.D. & Franck Chiappini Ph.D.

  5. Service de Biochimie, Hôpital Tenon, Université Pierre et Marie Curie, Assistance Publique, Paris, France

    Chantal Tse Ph.D. & Didier Brault Ph.D.

Authors
  1. Alain Barrier M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pierre-Yves Boelle Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Antoinette Lemoine Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chantal Tse Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Didier Brault Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Franck Chiappini Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. François Lacaine M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sidney Houry M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Michel Huguier M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Antoine Flahault M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Sandrine Dudoit Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by a grant from the Fondation de France/Fédération Nationale des Centres de Lutte Contre le Cancer for a stay in the Division of Biostatistics at the University of California, Berkeley (AB).

About this article

Cite this article

Barrier, A., Boelle, PY., Lemoine, A. et al. Gene Expression Profiling of Nonneoplastic Mucosa May Predict Clinical Outcome of Colon Cancer Patients. Dis Colon Rectum 48, 2238–2248 (2005). https://doi.org/10.1007/s10350-005-0175-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10350-005-0175-9

Key words

Search

Navigation