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Treatment of Grade III Anal Intraepithelial Neoplasia With Photodynamic Therapy

Report of a Case

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Diseases of the Colon & Rectum

Abstract

PURPOSE: We report the use of photodynamic therapy to treat a 53-year-old female with Grade III anal intraepithelial neoplasia. METHODS: Topical 5-aminolevulinic acid cream was applied to the affected area five hours before light treatment. The distribution of 5-aminolevulinic acid–induced protoporphyrin IX was identified by its characteristic red fluorescence. The lesion was treated by illumination with a 630-nm red laser light that used a total energy of 125 J/cm2 for approximately 17 minutes. RESULTS: Complete symptomatic relief was achieved after the first photodynamic therapy session, and macroscopic and microscopic ablation of dysplasia was achieved after a second session of photodynamic therapy. Healing was excellent, with no residual scarring or functional loss. CONCLUSION: Photodynamic therapy offers a simple, noninvasive method for treatment of anal intraepithelial neoplasia.

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Authors and Affiliations

  1. Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, Dundee; Department of Physics and Astronomy, Glasgow University, Glasgow; and Department of Pathology, Ninewells Hospital, Dundee, United Kingdom

    Khaled A. Hamdan M.R.C.S.(Edinb.), Iain S. Tait Ph.D., Valerie Nadeau B.Sc., Miles Padgett Ph.D., Frank Carey M.D. & Robert J. Steele M.D.

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  1. Khaled A. Hamdan M.R.C.S.(Edinb.)
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  2. Iain S. Tait Ph.D.
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  3. Valerie Nadeau B.Sc.
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  4. Miles Padgett Ph.D.
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  5. Frank Carey M.D.
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  6. Robert J. Steele M.D.
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Hamdan, K.A., Tait, I.S., Nadeau, V. et al. Treatment of Grade III Anal Intraepithelial Neoplasia With Photodynamic Therapy. Dis Colon Rectum 46, 1555–1559 (2003). https://doi.org/10.1007/s10350-004-6813-9

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  • DOI: https://doi.org/10.1007/s10350-004-6813-9

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