Abstract
PURPOSE: Carcinoembryonic antigen is the classical tumor marker for colorectal cancer. The main clinical utility is in monitoring patients with colorectal cancer. Like carcinoembryonic antigen, the plasma level of CA 242 is elevated in patients with colorectal cancer. The purpose of this study was to investigate whether the plasma levels of carcinoembryonic antigen and/or CA 242 were elevated before clinical diagnosis of colorectal cancer. METHODS: The Northern Sweden Health and Disease Cohort was linked to the Swedish National and Regional Cancer registries, and 124 prospective cases with colorectal cancer were identified. Two referents for each case were randomly selected and matched for gender, age, date of sampling, and fasting time. Plasma from the included patients was analyzed for carcinoembryonic antigen and CA 242 using specific immunoassays. RESULTS: An elevated level of carcinoembryonic antigen before diagnosis was associated with an increased risk of developing manifest colorectal cancer (adjusted odds ratio, 7.9; 95 percent confidence interval, 2.1–29.1; P = 0.002). An elevated level of CA 242 was not significantly related to colorectal cancer risk. Elevated carcinoembryonic antigen levels were only seen in samples collected in the two-year time interval immediately before diagnosis. In this group, 30.4 percent of all plasma samples from cases were carcinoembryonic antigen-positive and 71.4 percent were future Dukes A or B cases. The specificity of the carcinoembryonic antigen test for identifying future colorectal cancer patients was 0.99 with a sensitivity of 0.12. For CA 242 the specificity was 0.92 and the sensitivity was 0.1. CONCLUSIONS: Elevated carcinoembryonic antigen levels strongly indicate occult colorectal cancer. Although the specificity of the carcinoembryonic antigen test in its present form is high, the sensitivity is disappointingly low, prohibiting the use of the carcinoembryonic antigen test for mass screening.
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References
P Gold SO Freedman (1965) ArticleTitleSpecific carcinoembryonic antigens of the human digestive system J Exp Med 122 467–481
. American Society of Clinical Oncology (1998) ArticleTitle1997 update of recommendations for the use tumour markers in breast and colorectal cancer J Clin Oncol 16 793–795
DJ Bruinvels AM Stiggelbout J Kievit HC van Houwelingen JD Habbemaa CJ van de Velde (1994) ArticleTitleFollow-up of patients with colorectal cancer. A meta-analysis Ann Surg 219 174–182
R Graham S Wang P Catalano D Haller (1998) ArticleTitlePostsurgical surveillance of colon cancer. Preliminary cost analysis of physical examination, carcinoembryonic antigen testing, chest x-ray and colonoscopy Ann Surg 228 59–63
MA Chapman D Buckley DB Henson NC Armitage (1998) ArticleTitlePreoperative carcinoembryonic antigen is related to tumor long-term survival in colorectal cancer Br J Cancer 78 1346–1349
A Quentmeier P Schlag P Hohenberger V Schwarz U Abel (1989) ArticleTitleAssessment of serial carcinoembryonic antigen J Surg Oncol 40 112–118
B Engarås (2003) ArticleTitleIndividual cutoff levels of carcinoembryonic antigen and CA 242 indicate recurrence of colorectal cancer with high sensitivity Dis Colon Rectum 46 313–321
B Engarås J Kewenter O Nilsson H Wedel L Hafström (2001) ArticleTitleCEA, CA 50 and CA 242 in patients surviving colorectal cancer without recurrent disease Eur J Surg Oncol 27 43–48
CG Moertel TR Fleming JS Macdonald DG Haller JA Laurie C Tangen (1993) ArticleTitleAn evaluation of the carcinoembryonic antigen (CEA) test for monitoring patients with resected colon cancer JAMA 270 943–947
S Hammarström (1999) ArticleTitleThe carcinoembryonic antigen (CEA) family Sem Cancer Biol 9 67–81
N Beauchemin P Draber G Dveksler et al. (1999) ArticleTitleRedefined nomenclature for members of the carcinoembryonic antigen family Exp Cell Res 252 243–249
Y Matsuoka Y Matsuo N Okamoto M Kuroki M Kuroki Y Ikehara (1991) ArticleTitleHighly effective extraction of carcinoembryonic antigen with phosphatidylinositol-specific phospholipase C Tumor Biol 12 91–98
S Benchimol A Fuks S Jothy N Beauchemin K Shirota CP Stanners (1989) ArticleTitleCarcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule Cell 57 327–334
B Öbrink (1997) ArticleTitleCEA adhesion molecules Curr Opin Cell Biol 9 171–177
S Hammarström V Baranov (2001) ArticleTitleIs there a role for CEA in innate immunity in the colon? Trends Microbiol 9 119–125
V Baranov MM Yeung S Hammarström (1994) ArticleTitleExpression of carcinoembryonic antigen and nonspecific cross-reactive 50 kDa antigen in human normal and cancerous colon mucosa Cancer Res 54 3305–3314
L Frängsmyr V Baranov S Hammarström (1999) ArticleTitleFour carcinoembryonic antigen (CEA) subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in normal human colon epithelium are integral components of the fuzzy coat Tumor Biol 20 277–292
LM Tibbetts CM Doremus GN Tzanakakis MP Vezeridis (1993) ArticleTitleLiver metastases with 10 human colon carcinoma cell lines in nude mice and association with carcinoembryonic antigen production Cancer 71 315–321
G Steele SuffixJr N Zamcheck (1985) ArticleTitleThe use of CEA in the clinical management of patients with colorectal cancer Cancer Detect Prev 8 421–427
OP Børmer E Paus K Nustad (1991) ArticleTitleTumour markers as seen from the clinical laboratory Scand J Clin Lab Invest 206 12–20
C Johansson O Nilsson D Bäckström EL Janson (1991) ArticleTitleNovel epitopes on the CA50-carrying antigen Tumor Biol 12 159–179
O Nilsson B Glimelius B Persson B Nörgaard-Pedersen Aring Andrén-Sandberg L Lindholm (1992) ArticleTitleSensitivity and specificity of CA 242 in gastrointestinal cancer. A comparison with CEA, CA50 and CA19–9 Br J Cancer 65 215–221
S von Kleist Y Hesse R Kananeeh (1996) ArticleTitleComparative evaluation of four tumour markers, CA 242, CA19-9, TPA and CEA in carcinomas of the colon Anticancer Res 16 2325–2332
M Carpelan-Holmström C Haglund J Lundin H Alfthan UH Stenman PJ Roberts (1996) ArticleTitleIndependent prognostic value of preoperative serum markers CA 242, specific tissue polypeptide antigen and human chorionic gonadotrophin beta, but not of carcinoembryonic antigen or tissue polypeptide antigen in colorectal cancer Br J Cancer 74 925–929
NA Scott HS Wieand CG Moertel SS Cha RW Beart MM Lieber (1987) ArticleTitleDukes’ Stage, tumor site, preoperative plasma CEA level, and patient prognosis related to tumor DNA ploidy pattern Arch Surg 122 1375–1379
TO Rognum HE Heier H Orjasaeter E Thorud P Brandtzaeg (1986) ArticleTitleComparison of two CEA assays in primary and recurrent large bowel carcinoma with different ploidy pattern Eur J Cancer Clin Oncol 22 1165–1169
JS Mandel JH Bond TR Church et al. (1993) ArticleTitleReducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study N Engl J Med 328 1365–1371
JD Hardcastle JO Chamberlain MH Robinson et al. (1996) ArticleTitleRandomised controlled trial of faecal-occult-blood screening for colorectal cancer Lancet 348 1472–1477
O Kronborg C Fenger J Olsen OD Jorgensen O Sondergaard (1996) ArticleTitleRandomised study of screening for colorectal cancer with faecal-occult-blood test Lancet 348 1467–1471
J Kewenter H Brevinge B Engaras E Haglind C Ahren (1994) ArticleTitleResults of screening, rescreening, and follow-up in a prospective randomized study for detection of colorectal cancer by fecal occult blood testing. Results for 68,308 subjects Scand J Gastroenterol 29 468–473
DA Lieberman DG Weiss JH Bond DJ Ahnen H Garewal G Chejfec (2000) ArticleTitleUse of colonoscopy to screen asymptomatic adults for colorectal cancer. Veterans Affairs Cooperative Study Group 380 N Engl J Med 343 162–168
L Weinehall O Johnson JH Jansson et al. (1998) ArticleTitlePerceived health modifies the effect of biomedical risk factors in the prediction of acute myocardial infarction. An incident case-control study from northern Sweden J Intern Med 243 99–107
B Engarås L Hafström J Kewenter O Nilsson H Wedel (1999) ArticleTitleStandard serum concentrations and normal fluctuations of CEA, CA 50 and CA 242 during twelve months in men and women aged 60–64 years without malignant disease Eur J Surg 165 110–116
G Lindmark R Bergström L Påhlman B Glimelius (1995) ArticleTitleThe association of preoperative serum tumour markers with Dukes’ stage and survival in colorectal cancer Br J Cancer 71 1090–1094
R Palmqvist R Stenling Aring Öberg G Landberg (1998) ArticleTitleExpression of cyclin D1 and retinoblastoma protein in colorectal cancer Eur J Cancer 34 1575–1581
R Goslin MJ O’Brien G Steele et al. (1981) ArticleTitleCorrelation of plasma CEA and CEA tissue staining in poorly differentiated colorectal cancer Am J Med 71 246–253
K Komoto J Furui M Haraguchi T Kanematsu (2000) ArticleTitleThe detection of colorectal cancer at an asymptomatic stage by screening is useful Hepatogastroenterology 47 1011–1014
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Palmqvist, R., Engarås, B., Lindmark, G. et al. Prediagnostic Levels of Carcinoembryonic Antigen and CA 242 in Colorectal Cancer: A Matched Case-Control Study. Dis Colon Rectum 46, 1538–1544 (2003). https://doi.org/10.1007/s10350-004-6810-z
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DOI: https://doi.org/10.1007/s10350-004-6810-z