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Detrimental Immunologic Effects of Preoperative Chemoradiotherapy in Advanced Rectal Cancer

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Diseases of the Colon & Rectum

Abstract

PURPOSE: Preoperative chemoradiotherapy for advanced rectal cancer has been an important therapeutic tool to improve the long-term results of curative resection. It is not known whether preoperative chemoradiotherapy for advanced rectal cancer influences the perioperative course of immune parameters. METHODS: Thirty patients with rectal cancer underwent surgery with (study group, n = 15) or without (control group, n = 15) preoperative chemoradiotherapy (2 cycles of 5-fluorouracil, 45 Gy). Blood samples were taken before neoadjuvant therapy, preoperatively, and on Days 1, 2, and 5 after surgery. Cell numbers of lymphocyte subpopulations, granulocytes, monocytes, and natural killer cells were determined by flow cytometry; tumor necrosis factor-α and interleukin-6 serum levels were measured with enzyme-linked immunosorbent assay. RESULTS: Significant differences between study and control patients (P < 0.05) were detected regarding circulating interleukin-6 and tumor necrosis factor-α levels, with depression of the proinflammatory response to surgery in study patients. Similarly, granulocytosis and monocytosis after surgery were significantly lower in patients after neoadjuvant therapy. Furthermore, cell counts of total T lymphocytes, T helper cells, B lymphocytes, and natural killer cells were significantly reduced after preoperative chemoradiotherapy. This depression of cell-mediated immunity in study patients was even more pronounced after surgery. CONCLUSIONS: Preoperative chemoradiotherapy for advanced rectal cancer results in a significant preoperative and postoperative immune dysfunction as indicated by depression of lymphocyte subpopulations, monocytes, granulocytes, and proinflammatory cytokine release. These findings are of importance because increased perioperative morbidity and mortality rates have been observed after preoperative chemoradiotherapy.

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Authors and Affiliations

  1. Departments of Surgery, Clinical Chemistry, Internal Medicine III, and Radiation Oncology, Ludwig-Maximilians-University, Klinikum Groβhadern, Munich, Germany

    Matthias W. Wichmann M.D., Günther Meyer M.D., Michaela Adam M.D., Wilma Höchtlen-Vollmar M.D., Martin K. Angele M.D., Andreas Schalhorn M.D., Ralf Wilkowski M.D., Christian Müller M.D. & Friedrich-Wilhelm Schildberg M.D.

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  1. Matthias W. Wichmann M.D.
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  2. Günther Meyer M.D.
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  3. Michaela Adam M.D.
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  4. Wilma Höchtlen-Vollmar M.D.
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  5. Martin K. Angele M.D.
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  6. Andreas Schalhorn M.D.
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  7. Ralf Wilkowski M.D.
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  8. Christian Müller M.D.
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  9. Friedrich-Wilhelm Schildberg M.D.
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Wichmann, M.W., Meyer, G., Adam, M. et al. Detrimental Immunologic Effects of Preoperative Chemoradiotherapy in Advanced Rectal Cancer. Dis Colon Rectum 46, 875–887 (2003). https://doi.org/10.1007/s10350-004-6677-z

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  • DOI: https://doi.org/10.1007/s10350-004-6677-z

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