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Outcome of Total Pelvic Exenteration for Primary Rectal Cancer

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Diseases of the Colon & Rectum

Abstract

PURPOSE: This retrospective study identifies the clinicopathologic factors (age, gender, size of tumor, location, tumor stage, lymph node metastasis, histologic differentiation, and adjuvant therapies) that are useful in predicting long-term survival in patients undergoing total pelvic exenteration for advanced primary rectal cancer. METHODS: We reviewed the medical records of 71 patients with stage T3 or T4 primary rectal cancer who underwent a curative total pelvic exenteration. The effects of various clinical variables on long-term survival were analyzed. RESULTS: The postoperative mortality, hospital death, and morbidity rates were 1.4, 4.2, and 66.2 percent, respectively. The overall five-year survival rate after total pelvic exenteration was 54.1 percent. The five-year survival rate was 65.7 percent for patients with T3 lesions and 39 percent for patients with T4 lesions. A univariate analysis showed that postoperative survival was affected by age, tumor stage, and lymph node metastasis, while a multivariate analysis showed that age and lymph node metastasis were independent prognostic factors. CONCLUSION: Total pelvic exenteration may enable long-term survival in younger patients with stage T3 or T4 primary rectal cancer and little or no lymph node metastasis.

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    Authors
    1. Hideyuki Ike M.D.
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    2. Hiroshi Shimada M.D.
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    3. Shigeki Yamaguchi M.D.
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    4. Yasushi Ichikawa M.D.
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    5. Shouichi Fujii M.D.
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    6. Shigeo Ohki M.D.
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    Ike, H., Shimada, H., Yamaguchi, S. et al. Outcome of Total Pelvic Exenteration for Primary Rectal Cancer. Dis Colon Rectum 46, 474–480 (2003). https://doi.org/10.1007/s10350-004-6585-2

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    • DOI: https://doi.org/10.1007/s10350-004-6585-2

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