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Aberrant Methylation of HLTF, SOCS-1, and CDH13 Genes Is Shown in Colorectal Cancers Without Lymph Node Metastasis

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Diseases of the Colon & Rectum

PURPOSE and METHODS

In this study, we examined the combined methylation status of HLTF, SOCS-1, and CDH13 in 61 resected primary colorectal cancers using methylation-specific polymerase chain reaction and correlated the number of methylated genes with the clinicopathologic features of affected patients.

RESULTS

We found a significant difference in lymph node metastasis (P = 0.020) when we compared the number of methylated genes in colorectal cancers with lymph node metastasis to those without it.

CONCLUSIONS

Colorectal cancers without lymph node metastasis frequently exhibited the aberrant methylation of HLTF , SOCS-1 , and CDH13 genes.

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ACKNOWLEDGMENTS

The authors thank M. Ume and T. Sakai for their technical assistance.

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Authors and Affiliations

  1. Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan

    Kenji Hibi M.D., Yasuhiro Kodera M.D., Katsuki Ito M.D., Seiji Akiyama M.D. & Akimasa Nakao M.D.

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  1. Kenji Hibi M.D.
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  2. Yasuhiro Kodera M.D.
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  3. Katsuki Ito M.D.
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  4. Seiji Akiyama M.D.
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  5. Akimasa Nakao M.D.
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Correspondence to Kenji Hibi M.D..

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Hibi, K., Kodera, Y., Ito, K. et al. Aberrant Methylation of HLTF, SOCS-1, and CDH13 Genes Is Shown in Colorectal Cancers Without Lymph Node Metastasis. Dis Colon Rectum 48, 1282–1286 (2005). https://doi.org/10.1007/s10350-004-0947-7

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  • DOI: https://doi.org/10.1007/s10350-004-0947-7

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