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High resolution fMRI of subcortical regions during visual erotic stimulation at 7 T

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Abstract

Object

Involvement of distinct subcortical structures during sexual arousal was shown in animals and functional imaging studies gave coarse evidence for a similar organisation in humans. In contrast to previous imaging studies at lower field strengths, we tried to investigate activation in distinguishable subcortical structures at high spatial resolution during a short stimulating paradigm to further account for potential effects of attenuation or adaptation.

Materials and methods

Seven healthy subjects were investigated using functional magnetic resonance imaging (fMRI) on a 7 T scanner. High resolution EPI images of 1.4 × 1.4 mm2 inplane resolution were acquired in a single functional session of 13.6 minutes. During the session erotic and non-erotic pictures were presented in an event-related design.

Results

In the unsmoothed data with preserved high spatial resolution significant effects were detected in relevant structures, including anterior caudate and mediodorsal thalamus. These effects were restricted to subcortical target structures and their anatomical boundaries.

Conclusion

This study demonstrates that fMRI at high fields provides an ideal tool to investigate functional anatomy of subcortical structures. Due to an increased signal-to-noise ratio, functional scans of short duration can be acquired at high resolution without the need for further spatial smoothing.

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References

  1. Ferretti A, Caulo M, Del Gratta C, Di Matteo R, Merla A, Montorsi F, Pizzella V, Pompa P, Rigatti P, Rossini PM, Salonia A, Tartaro A, Romani GL (2005) Dynamics of male sexual arousal: distinct components of brain activation revealed by fMRI. Neuroimage 26(4): 1086–1096

    Article  PubMed  Google Scholar 

  2. Moulier V, Mouras H, Pelegrini-Issac M, Glutron D, Rouxel R, Grandjean B, Bittoun J, Stoleru S (2006) Neuroanatomical correlates of penile erection evoked by photographic stimuli in human males. Neuroimage 33(2): 689–699

    Article  CAS  PubMed  Google Scholar 

  3. Redoute J, Stoleru S, Gregoire MC, Costes N, Cinotti L, Lavenne F, Le Bars D, Forest MG, Pujol JF (2000) Brain processing of visual sexual stimuli in human males. Hum Brain Mapp 11(3): 162–177

    Article  CAS  PubMed  Google Scholar 

  4. Arnow BA, Desmond JE, Banner LL, Glover GH, Solomon A, Polan ML, Lue TF, Atlas SW (2002) Brain activation and sexual arousal in healthy, heterosexual males. Brain 125(Pt 5): 1014–1023

    Article  PubMed  Google Scholar 

  5. Fisher H, Aron A, Brown LL (2005) Romantic love: an fMRI study of a neural mechanism for mate choice. J Comp Neurol 493(1): 58–62

    Article  PubMed  Google Scholar 

  6. Aron A, Fisher H, Mashek DJ, Strong G, Li H, Brown LL (2005) Reward, motivation, and emotion systems associated with early-stage intense romantic love. J Neurophysiol 94(1): 327–337

    Article  PubMed  Google Scholar 

  7. McKenna K (1999) The brain is the master organ in sexual function: central nervous system control of male and female sexual function. Int J Impot Res 11(Suppl 1): S48–55

    Article  PubMed  Google Scholar 

  8. Fisher HE, Aron A, Brown LL (2006) Romantic love: a mammalian brain system for mate choice. Philos Trans R Soc Lond B Biol Sci 361(1476): 2173–2186

    Article  CAS  PubMed  Google Scholar 

  9. Mouras H, Stoleru S, Bittoun J, Glutron D, Pelegrini-Issac M, Paradis AL, Burnod Y (2003) Brain processing of visual sexual stimuli in healthy men: a functional magnetic resonance imaging study. Neuroimage 20(2): 855–869

    Article  PubMed  Google Scholar 

  10. Heinzel A, Walter M, Schneider F, Rotte M, Matthiae C, Tempelmann C, Heinze HJ, Bogerts B, Northoff G (2006) Self-related processing in the sexual domain: parametric event-related fMRI study reveals neural activity in ventral cortical midline structures. Soc Neurosci 1(1): 41–51

    Article  PubMed  Google Scholar 

  11. Bartels A, Zeki S (2000) The neural basis of romantic love. Neuroreport 11(17): 3829–3834

    Article  CAS  PubMed  Google Scholar 

  12. Gati JS, Menon RS, Ugurbil K, Rutt BK (1997) Experimental determination of the BOLD field strength dependence in vessels and tissue. Magn Reson Med 38(2): 296–302

    Article  CAS  PubMed  Google Scholar 

  13. Yacoub E, Shmuel A, Pfeuffer J, Van De Moortele PF, Adriany G, Andersen P, Vaughan JT, Merkle H, Ugurbil K, Hu X (2001) Imaging brain function in humans at 7 T. Magn Reson Med 45(4): 588–594

    Article  CAS  PubMed  Google Scholar 

  14. Pfeuffer J, van de Moortele PF, Yacoub E, Shmuel A, Adriany G, Andersen P, Merkle H, Garwood M, Ugurbil K, Hu X (2002) Zoomed functional imaging in the human brain at 7 T with simultaneous high spatial and high temporal resolution. Neuroimage 17(1): 272–286

    Article  PubMed  Google Scholar 

  15. Gizewski ER, de Greiff A, Maderwald S, Timmann D, Forsting M, Ladd ME (2007) fMRI at 7 T: whole-brain coverage and signal advantages even infratentorially. Neuroimage 37(3): 761–768

    Article  PubMed  Google Scholar 

  16. Kruger G, Glover GH (2001) Physiological noise in oxygenation-sensitive magnetic resonance imaging. Magn Reson Med 46(4): 631–637

    Article  CAS  PubMed  Google Scholar 

  17. Triantafyllou C, Hoge RD, Krueger G, Wiggins CJ, Potthast A, Wiggins GC, Wald LL (2005) Comparison of physiological noise at 1.5 T, 3 T and 7 T and optimization of fMRI acquisition parameters. Neuroimage 26(1): 243–250

    Article  CAS  PubMed  Google Scholar 

  18. Dale AM (1999) Optimal experimental design for event-related fMRI. Hum Brain Mapp 8(2–3): 109–114

    Article  CAS  PubMed  Google Scholar 

  19. Lehericy S, Bardinet E, Tremblay L, Vande Moortele PF, Pochon JB, Dormont D, Kim DS, Yelnik J, Ugurbil K (2006) Motor control in basal ganglia circuits using fMRI and brain atlas approaches. Cereb Cortex 16(2): 149–161

    Article  PubMed  Google Scholar 

  20. Brickenkamp R, Zillmer E (1998) d2 test of attention. Hogrefe, Goettingen

    Google Scholar 

  21. Walter M, Witzel J, Wiebking C, Gubka U, Rotte M, Schiltz K, Bermpohl F, Tempelmann C, Bogerts B, Heinze HJ, Northoff G (2007) Pedophilia is linked to reduced activation in hypothalamus and lateral prefrontal cortex during visual erotic stimulation. Biol Psychiatry

  22. Lang PJ, Bradley MM, Cuthbert BN (2005) International affective picture system (IAPS): affective ratings of pictures and instruction manual. Technical Report A-6. University of Florida, Gainesville

  23. Zaitsev M, Hennig J, Speck O (2004) Point spread function mapping with parallel imaging techniques and high acceleration factors: fast, robust, and flexible method for echo-planar imaging distortion correction. Magn Reson Med 52(5): 1156–1166

    Article  CAS  PubMed  Google Scholar 

  24. Goebel R. Brainvoyager QX (2006) 1.8. Maastricht: braininnovation. http://www.BrainVoyager.com

  25. Goebel R, Esposito F, Formisano E (2006) Analysis of functional image analysis contest (FIAC) data with brainvoyager QX: from single-subject to cortically aligned group general linear model analysis and self-organizing group independent component analysis. Hum Brain Mapp 27(5): 392–401

    Article  PubMed  Google Scholar 

  26. Bullmore E, Brammer M, Williams SC, Rabe-Hesketh S, Janot N, David A, Mellers J, Howard R, Sham P (1996) Statistical methods of estimation and inference for functional MR image analysis. Magn Reson Med 35(2): 261–277

    Article  CAS  PubMed  Google Scholar 

  27. Della-Maggiore V, Chau W, Peres-Neto PR, McIntosh AR (2002) An empirical comparison of SPM preprocessing parameters to the analysis of fMRI data. Neuroimage 17(1): 19–28

    Article  PubMed  Google Scholar 

  28. Friston KJ, Holmes AP, Worsley KJ, Poline JP, Frith CD, Frackowiak RS (1994) Statistical parametric maps in functional imaging: A general linear approach. Hum Brain Mapp 2(4): 189–210

    Article  Google Scholar 

  29. Genovese CR, Lazar NA, Nichols T (2002) Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 15(4): 870–878

    Article  PubMed  Google Scholar 

  30. Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Roy Stat Soc Ser B 57: 289–300

    Google Scholar 

  31. Nichols T, Hayasaka S (2003) Controlling the familywise error rate in functional neuroimaging: a comparative review. Stat Methods Med Res 12(5): 419–446

    Article  PubMed  Google Scholar 

  32. Logan BR, Rowe DB (2004) An evaluation of thresholding techniques in fMRI analysis. Neuroimage 22(1): 95–108

    Article  PubMed  Google Scholar 

  33. Friston KJ, Frith CD, Liddle PF, Frackowiak RS (1991) Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab 11(4): 690–699

    CAS  PubMed  Google Scholar 

  34. Worsley KJ, Evans AC, Marrett S, Neelin P (1992) A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab 12(6): 900–918

    CAS  PubMed  Google Scholar 

  35. Worsley KJ, Marrett S, Neelin P, Vandal AC, Friston KJ, Evans AC (1996) A unified statistical approach for determining significant signals in images of cerebral activation. Hum Brain Mapp 4(1): 58–73

    Article  Google Scholar 

  36. Mai J, Assheuer J, Paxinos G (2004) Atlas of the human brain. Academic Press/Elsevier, San Diego

    Google Scholar 

  37. Karama S, Lecours AR, Leroux JM, Bourgouin P, Beaudoin G, Joubert S, Beauregard M (2002) Areas of brain activation in males and females during viewing of erotic film excerpts. Hum Brain Mapp 16(1): 1–13

    Article  PubMed  Google Scholar 

  38. Kranz F, Ishai A (2006) Face perception is modulated by sexual preference. Curr Biol 16(1): 63–68

    Article  CAS  PubMed  Google Scholar 

  39. Barbas H (2005) Connections underlying the synthesis of cognition, memory, and emotion in primate prefrontal cortices. Brain Res Bull 52(5): 319–330

    Article  Google Scholar 

  40. Schlag J, Schlag-Rey M (1984) Visuomotor functions of central thalamus in monkey. II. Unit activity related to visual events, targeting, and fixation. J Neurophysiol 51(6): 1175–1195

    CAS  PubMed  Google Scholar 

  41. Schlag-Rey M, Schlag J (1984) Visuomotor functions of central thalamus in monkey. I. Unit activity related to spontaneous eye movements. J Neurophysiol 51(6): 1149–1174

    CAS  PubMed  Google Scholar 

  42. Macchi G, Bentivoglio M, Molinari M, Minciacchi D (1984) The thalamo-caudate versus thalamo-cortical projections as studied in the cat with fluorescent retrograde double labeling. Exp Brain Res 54(2): 225–239

    Article  CAS  PubMed  Google Scholar 

  43. Aron A, Aron EN (1991) Love and sexuality. In: McKinney K, Sprecher S(eds) Sexuality in close relationships. Erlbaum, Hillsdale, pp 25–48

    Google Scholar 

  44. Stoleru S, Gregoire MC, Gerard D, Decety J, Lafarge E, Cinotti L, Lavenne F, Le Bars D, Vernet-Maury E, Rada H, Collet C, Mazoyer B, Forest MG, Magnin F, Spira A, Comar D (1999) Neuroanatomical correlates of visually evoked sexual arousal in human males. Arch Sex Behav 28(1): 1–21

    Article  CAS  PubMed  Google Scholar 

  45. Hallgren B, Sourander P (1958) The effect of age on the non-haemin iron in the human brain. J Neurochem 3(1): 41–51

    Article  CAS  PubMed  Google Scholar 

  46. Aoki S, Okada Y, Nishimura K, Barkovich AJ, Kjos BO, Brasch RC, Norman D (1989) Normal deposition of brain iron in childhood and adolescence: MR imaging at 1.5 T. Radiology 172(2): 381–385

    CAS  PubMed  Google Scholar 

  47. White T, O’Leary D, Magnotta V, Arndt S, Flaum M, Andreasen NC (2001) Anatomic and functional variability: the effects of filter size in group fMRI data analysis. Neuroimage 13(4): 577–588

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Psychiatry, University Hospital Otto v. Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany

    Martin Walter & Georg Northoff

  2. Leibniz Institute for Neurobiology, Magdeburg, Germany

    Joerg Stadler

  3. Department of Neurology II, University Hospital Otto v. Guericke University, Magdeburg, Germany

    Claus Tempelmann

  4. Department of Biomedical Magnetic Resonance, FNW, Otto v. Guericke University, Magdeburg, Germany

    Oliver Speck

Authors
  1. Martin Walter
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  2. Joerg Stadler
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  3. Claus Tempelmann
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  4. Oliver Speck
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  5. Georg Northoff
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Corresponding author

Correspondence to Martin Walter.

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Walter, M., Stadler, J., Tempelmann, C. et al. High resolution fMRI of subcortical regions during visual erotic stimulation at 7 T. Magn Reson Mater Phy 21, 103 (2008). https://doi.org/10.1007/s10334-007-0103-1

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  • DOI: https://doi.org/10.1007/s10334-007-0103-1

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