Abstract
Objective: To describe an Internet-accessible database that contains validated in vivo MR spectra and clinical data of brain tumour patients. Materials and methods: All data from patients entering the INTERPRET project (International Network for Pattern Recognition of Tumours Using Magnetic Resonance, http://azizu.uab.es/INTERPRET) were stored in a web-accessible database (iDB) and selected using its query functionality. Criteria for selection were that the case had a single voxel (SV) short-echo (20–32 ms) 1.5 T spectrum acquired from a nodular region of the tumour, that the voxel had been positioned in the same region as where subsequent biopsy was obtained, that the short-echo spectrum had not been discarded because of acquisition artefacts or other reasons, and that a histopathological diagnosis was agreed among a committee of neuropathologists. When the spectra were obtained from normal volunteers or were of abscesses or clinically proven metastases, biopsy was not required. Results: A subset of 304 cases (22 normal volunteers and 282 tumour patients) was obtained. These cases were migrated to another similar database (validated-DB). Conclusion: The validated-DB complies with ethics regulations and represents the population studied. It is accessible by neuroradiologists willing to use information provided by MRS to help in the non-invasive diagnosis of brain tumours
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Rohringer M, Sutherland GR, Louw DF, Sima AA (1989) Incidence and clinicopathological features of meningioma. J Neurosurg 71(5 Pt 1):665–72
Kleihues P, Cavenee WK editors (2000) Pathology and genetics of tumours of the nervous system (World Health Organization Classification of Tumours) 2nd edn. IARC Press, Lyon
Bunin GR, Surawicz TS, Witman PA, Preston-Martin S, Davis F, Bruner JM (1998) The descriptive epidemiology of craniopharyngioma. J Neurosurg 89(4):547–51
Danielsen ER, Ross B (1999) Magnetic resonance spectroscopy diagnosis of neurological diseases. Marcel Dekker, New York
Alger JR, Frew AJ, Cloughesy TF, del Vecchio W, Villablanca JP, Curran JG (2002) Novel methodology for the archiving and interactive reading of clinical magnetic resonance spectroscopic imaging. Magn Reson Med 48:411–418
INTERPRET project: http://azizu.uab.es/INTERPRET
validated-DB: http://azizu.uab.es/INTERPRET/int_Disc_FrozenDB.shtml
Magnetic resonance spectroscopy protocols: http://azizu.uab.es/INTERPRET/mrs_data/mrs_data.html
Tate AR, Majos C, Moreno A, Howe FA, Griffiths JR, Arus C (2003) Automated classification of short echo time in in vivo 1H brain tumor spectra: a multicenter study. Magn Reson Med 49 (1): 29–36
Clinical data protocols: http://azizu.uab.es/INTERPRET/clinical_data/clinical_data.html
Candiota AP, Majos C, Bassols A, Cabanas ME, Acebes JJ, Quintero MR, Arus C (2004) Assignment of the 2.03 ppm resonance in in vivo 1H MRS of human brain tumour cystic fluid: contribution of macromolecules. MAGMA, Magn Reson Mater Phy 17 (1): 36–46
Quality Control of MR spectra: http://azizu.uab.es/INTERPRET/mrs_data/docs/MRS_QC.pdf
List of signed diagnoses: http://azizu.uab.es/INTERPRET/private/technical_reports.shtmlDocument number: 164
Lefournier V, Underwood J, Bosson J, Julià-Sapé M, Van Der Graaf M, Howe F, Majós C, Moreno A, Rémy C, Arús C (2004) The added value of single-voxel proton magnetic resonance. MAGMA, Magn Reson Mater Phy 17(1):49
Murphy M, Loosemore A, Ferrer I, Wesseling P, Wilkins PR, Bell BA (2002) Neuropathological diagnostic accuracy. Br J Neurosurg 16(5):461–464
Tate AR, Griffiths JR, Martinez-Perez I, Moreno A, Barba I, Cabanas ME, Watson D, Alonso J, Bartumeus F, Isamat F, Ferrer I, Vila F, Ferrer E, Capdevila A, Arus C (1998) Towards a method for automated classification of 1H MRS spectra from brain tumours. NMR Biomed 11(4,5):177–191
European Parliament and Council. Directive 95/46/EC (1995) Official Journal 281:0031–0050 http://europa.eu.int/comm/internal_market/privacy/law_en.htm#directive
Juan Carlos I. Ley Orgánica 15/1999 de Protección de Datos (1999) Boletín Oficial del Estado (BOE), 298:43088–43099 http://www.boe.es/boe/dias/1999-12-14/pdfs/A43088-43099.pdf
Ohgaki H, Kleihues P (2005) Epidemiology and etiology of gliomas. Acta Neuropathol (Berl) 109(1):93–108
Posner JB, Chernik NL (1978) Intracranial metastases from systemic cancer. Adv Neurol 19:579–592
Osborn AG (eds). (1994) Diagnostic neuroradiology Mo. Mosby, St Louis
eTUMOUR project: http://biospin.uv.es or http://www.etumour.net
Remmelinck M, Lopes MB, Nagy N, Rorive S, Rombaut K, Decaestecker C, Kiss R, Salmon I (2000) How could static telepathology improve diagnosis in neuropathology?. Anal Cell Pathol 21(3,4):177–82
Acosta DM, van der Graaf M, Julià-Sapé M, Rijpkema M, Moreno A, Majós C, Howe F, Arús C, Watson D (2002) An automated empirical approach for quality control filtering of single voxel 1H spectra for brain tumour classification. MAGMA, Magn Reson Mater Phy 15(1):140–141
Kreis R (2004) Issues of spectral quality in clinical 1H-magnetic resonance spectroscopy and a gallery of artifacts. NMR Biomed 17(6):361–81
Author information
Authors and Affiliations
Consortia
Corresponding author
Rights and permissions
About this article
Cite this article
Julià-Sapé, M., Acosta, D., Mier, M. et al. A Multi-Centre, Web-Accessible and Quality Control-Checked Database of in vivo MR Spectra of Brain Tumour Patients. Magn Reson Mater Phy 19, 22–33 (2006). https://doi.org/10.1007/s10334-005-0023-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10334-005-0023-x