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Characterization and detection of experimental rat gliomas using magnetic resonance imaging

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Abstract

Two different experimental rat brain tumours (F98 glioma and 9L glioma) were characterized using T1 and T2, apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR). Even though both tumours appeared homogenous at the early stage of growth, significant differences were measured for all parametric images between tumours and normal brain tissue. Irrespective of the sequence used, tumour lesion/normal parenchyma contrast for the non-infiltrative 9L was twice that of the infiltrative F98 glioma. The use of spin preparation via an inversion pulse in a fast spin echo sequence increases contrast by a factor of 20–30.

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Acknowledgments.

We would like to thank Dr. Anne Clavreul and Dr. Manuel Delhaye for supplying the F98 glioma cells and also recognize the employees of “animalerie hospitalo-universitaire d’Angers” for their assistance in the animal experimentation. This work is part of the INSERM-CNRS ‘Imagerie du Petit Animal’ project—grant number 8BG02H.

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Authors and Affiliations

  1. Inserm U646, “Ingénierie de la Vectorisation Particulaire” bâtiment IBT, 10, rue André Boquel, 49100, Angers, France

    A. Vonarbourg, A. Sapin, L. Lemaire, P. Jallet & J.J. Le Jeune

  2. Service Commun d’analyses spectroscopiques, Université d’Angers, Angers, France

    F. Franconi

  3. Neurochirurgie, C.H.U. d’Angers, 4, rue Larrey, 49100, Angers, France

    P. Menei

Authors
  1. A. Vonarbourg
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  2. A. Sapin
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  3. L. Lemaire
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  4. F. Franconi
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  5. P. Menei
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  6. P. Jallet
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  7. J.J. Le Jeune
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Correspondence to L. Lemaire.

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Vonarbourg, A., Sapin, A., Lemaire, L. et al. Characterization and detection of experimental rat gliomas using magnetic resonance imaging. MAGMA 17, 133–139 (2004). https://doi.org/10.1007/s10334-004-0049-5

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  • DOI: https://doi.org/10.1007/s10334-004-0049-5

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