Abstract
Objective
To study the expressions of FAK and Pyk2 in human astrocytic tumors and their relationship with angiogenesis.
Methods
The S-P immunohistochemical method was used to measure the expressions of FAK, Pyk2 and VEGF proteins in 58 human brain astrocytic tumors, and microvessel density (MVD) was detected by CD31 staining.
Results
In astrocytic tumors with I, II, III and IV grades, the positive rates of FAK were 20.00%, 26.67%, 44.44% and 50.00%, respectively, those of Pyk2 were 40.00%, 60.00%, 77.78% and 85.00%, respectively. FAK and Pyk2 expressions, especially Pyk2, correlated positively with VEGF expression and MVD.
Conclusion
FAK and Pyk2 plays the important role in astrocytic tumor angiogenesis through regulation to VEGF.
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References
Li ZQ, Yuan XH, Wu T, et al. Expression of VEGF, MMPs and its relation with vascular ultrastructure in primary and recurrent gliomas. Chin J Neuromed (Chinese), 2005, 4: 994–997.
Wu ZM, Yuan XH, Jiang PC, et al. Influence of focal adhesion kinase on the biological behaviors of human glioma cells. Chin J Exper Surg (Chinese), 2006, 23: 351–353.
Jiang PC, Li ZQ, Yuan XH. Effect of VEGF and its antisense oligodeoxynucleotides on glioma angiogenesis. Chin J Exper Surg (Chinese), 2003, 20: 43–44.
Weidner N, Semple JP, Welch WR, et al. Tumor angiogenesis and metastasis correlation in invasive breast carcinoma. N Engl J Med, 1991, 324: 1–8.
Sakamoto Y, Ogita H, Hirota T, et al. Interaction of integrin alpha (v) beta3 with nectin. Implication in cross-talk between cell-matrix and cell-cell junctions. J Biol Chem, 2006, 281: 19631–19644.
Akagi T, Murata K, Shishido T, et al. v-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and HRas. Mol Cell Biol, 2002, 22: 7015–7023.
Stanizone R, Picascia A, Chieffi P, et al. Variations of proline-rich kinase Pyk2 expression correlate with prostate cancer progression. Lab Invest, 2001, 81: 51–59.
Guo HJ, Wang X, Liu YC, et al. Expression of proline-rich tyrosine kinase-2(Pyk2) in gastric carcinoma and its significance. J Peking Univ (Health Sci) (Chinese), 2005, 37: 261–264.
Gutenberg A, Bruck W, Buchfelder M, et al. Expression of tyrosine kinases FAK and Pyk2 in 331 human astrocytomas. Acta Neuropathol, 2004, 108: 224–230.
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Supported by grants from the Science Research Foundation of Health Department of Hubei Province (No. JX1B019) and the Science Research Foundation of Wuahn University (No. 301270064).
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Li, Z., Yuan, X., Wu, Z. et al. Expressions of FAK and Pyk2 in human astrocytic tumors and their relationship with angiogenesis. Chin. -Ger. J. Clin. Oncol. 7, 658–660 (2008). https://doi.org/10.1007/s10330-008-0112-1
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DOI: https://doi.org/10.1007/s10330-008-0112-1