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Synthesis of 3-carboxycoumarins at room temperature in water extract of banana peels

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Abstract

The 3-carboxycoumarin is a major heterocycle in many biologically active agents, including anti-cancer, antibacterial and cosmetics. 3-Carboxycoumarins are also involved in the actions of plant growth hormones and growth regulators. Many catalytic systems have been used for the synthesis of 3-carboxycoumarins but such systems present issues such as harsh reaction conditions, tedious work-up and use of toxic solvents. Therefore, here we tested the synthesis of 3-carboxycoumarins by one-pot Knoevenagel condensation and intramolecular cyclization of various 2-hydroxybenzaldehydes with meldrum’s acid, using water extract of banana. Products were obtained in 76–94% yields in 420–490 min at room temperature by simple filtration.

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Acknowledgements

Authors are thankful to CSIR, New Delhi, India for financial assistance under the major research project [F.No.02 (0130)/13/EMR-II]; Authors are also thankful to SAIF, Punjab University, Chandigarh, for providing analytical facilities for characterization of compounds.

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Authors and Affiliations

  1. Department of Pesticides and Agrochemicals, School of Chemical Sciences, North Maharashtra University, Jalgaon, Maharashtra, 425001, India

    Suresh D. Bagul, Jamatsing D. Rajput & Ratnamala S. Bendre

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  1. Suresh D. Bagul
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  2. Jamatsing D. Rajput
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  3. Ratnamala S. Bendre
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Correspondence to Ratnamala S. Bendre.

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Bagul, S.D., Rajput, J.D. & Bendre, R.S. Synthesis of 3-carboxycoumarins at room temperature in water extract of banana peels. Environ Chem Lett 15, 725–731 (2017). https://doi.org/10.1007/s10311-017-0645-z

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  • DOI: https://doi.org/10.1007/s10311-017-0645-z

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