Abstract
Deep eutectic solvents are becoming more popular nowadays since they are green, safe and often save raw materials and energy compared to organic solvent. Due to the importance of environmentally compatible solvent in multicomponent reactions, herein we report an efficient and sustainable catalyst-free synthesis of imidazo [1,2-a] pyridines via Groebke multicomponent reaction in choline chloride-based deep eutectic solvent. One-pot, three-component reaction of 2-amino pyridine, aromatic aldehydes and cyclohexyl isocyanide in six different choline chloride-based deep eutectic solvents in the absence of catalyst were examined. Urea–choline chloride was selected as an efficient solvent for this isocyanide-based multicomponent reaction and afforded the imidazo [1,2-a] pyridines in good yields of 57–87 % and reaction times of 2–6 h. The method has several advantages such as environmentally benign and biodegradable solvent, easy purification processes by a simple filtration and methodological simplicity.
Similar content being viewed by others
Abbreviations
- HIV:
-
Human immunodeficiency virus
- DES:
-
Deep eutectic solvent
- IL:
-
Ionic liquid
- VOC:
-
Volatile organic compound
- VOS:
-
Volatile organic solvent
- NMR:
-
Nuclear magnetic resonance
- 1H NMR:
-
Proton nuclear magnetic resonance spectroscopy
- TMS:
-
Tetramethylsilane
- TLC:
-
Thin layer chromatography
- DMSO:
-
Dimethyl sulfoxide
- CDCl3 :
-
Deuterated chloroform
- FT-IR:
-
Fourier transform infrared spectroscopy
- PTSA:
-
Para toluene sulfonic acid
- ChCl:
-
Choline chloride
References
Abbott AP, Capper G, Davies DL, Rasheed RK, Tambyrajah V (2003) Novel solvent properties of choline chloride/urea mixtures. Chem Commun. doi:10.1039/B210714G
Abo-Hamad A, Hayyan M, AlSaadi MA, Hashim MA (2015) Potential applications of deep eutectic solvents in nanotechnology. Chem Eng J 273:551–576. doi:10.1016/j.cej.2015.03.091
Adib M, Mahdavi M, Noghani MA, Mirzaei P (2007) Catalyst-free three-component reaction between 2-aminopyridines (or 2-aminothiazoles), aldehydes, and isocyanides in water. Tetrahedron Lett 48:7263–7265. doi:10.1016/j.tetlet.2007.08.049
Al-Tel TH, Al-Qawasmeh RA (2010) Post Groebke–Blackburn multicomponent protocol: synthesis of new polyfunctional imidazo [1,2-a] pyridine and imidazo [1,2-a] pyrimidine. Eur J Med Chem 45:5848–5855. doi:10.1016/j.ejmech.2010.09.049
Azizi N, Batebi E (2012) Highly efficient deep eutectic solvent catalyzed ring opening of epoxides. Catal Sci Technol 2:2445–2448. doi:10.1039/C2CY20456H
Azizi N, Gholibeglo E (2012) A highly efficient synthesis of dithiocarbamates in green reaction media. RSC Adv 2:7413–7416. doi:10.1039/C2RA20615C
Azizi N, Saidi MR (2003) Lithium perchlorate diethyl ether solution: a highly efficient media for the Abramov reaction. Phosphorus Sulfur Silicon Relat Elem 178:1255–1259. doi:10.1080/10426500307904
Bienayme H, Bouzid K (1998) A new heterocyclic multicomponent reaction for the combinatorial synthesis of fused 3-aminoimidazoles. Angew Chem Int Ed 37:2234–2237. doi:10.1002/(SICI)1521-3773(19980904)
Blackburn C (1998) A three-component solid-phase synthesis of 3-aminoimidazo [1, 2-a] azines. Tetrahedron Lett 9:5469–5472. doi:10.1016/S0040-4039(98)01113-7
Blackburn C, Guan B (2000) A novel dealkylation affording 3-aminoimidazo [1, 2] pyridines: access to new substitution patterns by solid-phase synthesis. Tetrahedron Lett 41:1495–1500. doi:10.1016/S0040-4039(00)00003-4
Groebke K, Weber L, Mehlin F (1998) Synthesis of imidazo [1, 2-a] annulated pyridines, pyrazines and pyrimidines by a novel three-component condensation. Synlett. doi:10.1055/s-1998-1721
Gueiffier A, Mavel S, Lhassani M, Elhakmaoui A, Snoeck R, Andrei G, Chavignon O, Teulade J-C, Witvrouw M, Balzarini J (1998) Synthesis of imidazo [1, 2-a] pyridines as antiviral agents. J Med Chem 41:5108–5112. doi:10.1021/jm981051y
Hayyan A, Mjalli FS, AlNashef IM, Al-Wahaibi T, Al-Wahaibi YM, Hashim MA (2012) Fruit sugar-based deep eutectic solvents and their physical properties. Thermochim Acta 541:70–75. doi:10.1016/j.tca.2012.04.030
Hayyan A, Hashim MA, Mjalli FS, Hayyan M, AlNashef IM (2013) A novel phosphonium-based deep eutectic catalyst for biodiesel production from industrial low grade crude palm oil. Chem Eng Sci 92:81–88. doi:10.1016/j.ces.2012.12.024
Katritzky AR, Xu YJ, Tu H (2003) Regiospecific synthesis of 3-substituted imidazo [1, 2-a] pyridines, imidazo [1, 2-a] pyrimidines, and imidazo [1, 2-c] pyrimidine. J Org Chem 68:4935–4937. doi:10.1021/jo026797p
Kishore KG, Basavanag UMV, Islas-Jácome A, Gámez-Montaño R (2015) Synthesis of imidazo [1,2-a] pyridin-chromones by a MW assisted Groebke–Blackburn–Bienaymé process. Tetrahedron Lett 56:155–158. doi:10.1016/j.tetlet.2014.11.047
Krasavin M, Tsirulnikov S, Nikulnikov M, Sandulenko Y, Bukhryakov K (2008) tert-Butyl isocyanide revisited as a convertible reagent in the Groebke–Blackburn reaction. Tetrahedron Lett 49:7318–7321. doi:10.1016/j.tetlet.2008.10.046
Lamberth C (2011) First synthesis of 3-amino-2-arylimidazo [1,2-B] pyridazines by Groebke–Blackburn reaction. Synlett 2011:1740–1744. doi:10.1055/s-0030-1260940
Liu P, Hao JW, Mo LP, Zhang ZH (2015) Recent advances in the application of deep eutectic solvents as sustainable media as well as catalysts in organic reactions. RSC Adv 5:48675–48704. doi:10.1039/C5RA05746A
Mirmashhori B, Azizi N, Saidi MR (2006) A simple, economical, and highly efficient synthesis of β-hydroxynitriles from epoxide under solvent free conditions. J Mole Catal A Chem 247:159–161. doi:10.1016/j.molcata.2005.11.042
Mjalli FS, Naser J, Jibril B, Alizadeh V, Gano Z (2014) Tetrabutylammonium chloride based ionic liquid analogues and their physical properties. J Chem Eng Data 59:2242–2251. doi:10.1021/je5002126
Parchinsky VZ, Shuvalova O, Ushakova O, Kravchenko DV, Krasavin M (2006) Multi-component reactions between 2-aminopyrimidine, aldehydes and isonitriles: the use of a nonpolar solvent suppresses formation of multiple products. Tetrahedron Lett 47:947–951. doi:10.1016/j.tetlet.2005.11.152
Phadtare SB, Jarag KJ, Shankarling GS (2013) Greener protocol for one pot synthesis of coumarinstyryl dyes. Dye Pigments 97:105–112. doi:10.1016/j.dyepig.2012.12.001
Rostamnia S, Hassankhani A (2013) RuCl 3-catalyzed solvent-free Ugi-type Groebke–Blackburn synthesis of aminoimidazole heterocycles. RSC Adv 3:18626–18629. doi:10.1039/C3RA42752H
Rostamnia S, Lamei K, Mohammadgholi M, Sheykhan M, Heydari A (2012) Nanomagnetically modified sulfuric acid (γ-Fe2O3@SiO2-OSO3H): an efficient, fast, and reusable green catalyst for the Ugi-like Groebke–Blackburn–Bienaymé three-component reaction under solvent-free conditions. Tetrahedron Lett 53:5257–5260. doi:10.1016/j.tetlet.2012.07.075
Rousseau AL, Matlaba P, Parkinson CJ (2007) Multicomponent synthesis of imidazo [1,2-a] pyridines using catalytic zinc chloride. Tetrahedron Lett 48:4079–4082. doi:10.1016/j.tetlet.2007.04.008
Shaabani A, Maleki A, Soleimani E (2007) Cellulose sulfuric acid catalyzed one-pot three-component synthesis of imidazoazines. Chem Pharm Bull 55:957–958. doi:10.1080/00397910802517871
Shaabani A, Soleimani E, Maleki A, Moghimi-Rad J (2008) Rapid synthesis of 3-Aminoimidazo [1, 2-a] pyridines and pyrazines. Synth Commun 38:1090–1095. doi:10.1080/00397910701862931
Shukla NM, Salunke DB, Yoo E, Mutz CA, Balakrishna R, David SA (2012) Antibacterial activities of Groebke–Blackburn–Bienaymé-derived imidazo [1,2-a] pyridin-3-amines. Bioorg Med Chem 20:5850–5863. doi:10.1016/j.bmc.2012.07.052
Singh BS, Lobo HR, Pinjari DV, Jarag KJ, Pandit AB, Shankarling GS (2013) Ultrasound and deep eutectic solvent (DES): a novel blend of techniques for rapid and energy efficient synthesis of oxazoles. Ultrason Sonochem 20:287–293. doi:10.1016/j.ultsonch.2012.06.003
Smith EL, Abbott AP, Ryder KS (2014) Deep eutectic solvents (DESs) and their applications. Chem Rev 114:11060–11082. doi:10.1021/cr300162p
Spisa FL, Meneghetti F, Pozzi B, Tron GC (2015) Synthesis of heteroarylogous 1H-indole-3-carboxamidines via a three-component interrupted ugi reaction. Synthesis 47:489–496. doi:10.1055/s-0034-1378921
Starrett JE Jr, Montzka TA, Crosswell AR, Cavanagh RL (1989) Synthesis and biological activity of 3-substituted imidazo [1, 2-a] pyridines as antiulcer agents. J Med Chem 32:2204–2210. doi:10.1021/jm00129a028
Tang B, Row KH (2013) Recent developments in deep eutectic solvents in chemical sciences. Monatsh Chem 144:1427–1454. doi:10.1007/s00706-013-1050-3
Vidyacharan S, Shinde AH, Satpathia B, Sharada DS (2014) A facile protocol for the synthesis of 3-aminoimidazo-fused heterocycles via the Groebke–Blackburn–Bienayme reaction under catalyst-free and solvent-free conditions. Green Chem 16:1168–1175. doi:10.1039/C3GC42130A
Yi Y-B, Lee J-W, Chung C-H (2015) Conversion of plant materials into hydroxymethylfurfural using ionic liquids. Environ Chem Lett 13:173–190. doi:10.1007/s10311-015-0503-9
Zhang Q, De Oliveira Vigier K, Royer S (2012) Deep eutectic solvents: syntheses, properties and applications. Chem Soc Rev 41:7108–7146. doi:10.1039/C2CS35178A
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Azizi, N., Dezfooli, S. Catalyst-free synthesis of imidazo [1,2-a] pyridines via Groebke multicomponent reaction. Environ Chem Lett 14, 201–206 (2016). https://doi.org/10.1007/s10311-015-0541-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10311-015-0541-3