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Ovarielle Protektion und Erhalt der Fertilität im Rahmen der Therapie gynäkologischer Malignome bei Kinderwunsch

Ovarian protection and preserving fertility during treatment for gynaecological malignancies when children are desired

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Gynäkologische Endokrinologie Aims and scope

Zusammenfassung

Neue reproduktionsmedizinische Techniken und ein steigendes Bewusstsein in der Bevölkerung für die Möglichkeit der Erfüllung eines Kinderwunsches nach einer Krebserkrankung haben zu einer zunehmenden Verbreitung fertilitätserhaltender Maßnahmen im Rahmen zytotoxischer Therapien geführt. Bei gynäkologischen Malignomen ist das Mammakarzinom von größter Relevanz, da ca. 2500 Frauen bis zu einem Alter von 35 Jahren/Jahr erkranken. Für den Fertilitätserhalt kommen IVF/ICSI-Behandlungen, die In-vitro-Maturation, die Oozytenkryokonservierung, die Kryokonservierung von Ovarialgewebe und die Gabe von GnRH-Analoga in Betracht. Allerdings ist die Wahrscheinlichkeit, dass die Patientin letztlich von diesen Therapien im Sinne der Geburt eines Kindes profitieren kann, begrenzt. Deswegen sollten diese Therapien nur nach einer sorgfältigen Risiko-Nutzen-Abwägung und nach einer ausführlichen interdisziplinären Beratung der Patientin angewendet werden.

Abstract

New reproductive techniques have led to the introduction of a broad spectrum of fertility-preserving techniques in patients treated by chemotherapy or radiation. Such techniques can also be offered to patients with gynaecological tumours, mainly those with carcinoma of the breast, as this cancer is diagnosed in around 2500 women at the age of 35 years and younger. The techniques which can be used are IVF/ICSI, in vitro maturation, oocyte cryopreservation, cryopreservation of ovarian tissue and treatment with gonadotropin-releasing agonists. However, as the chance that these patients will actually profit from the therapies by delivering a child is rather low, these therapies should only be offered under certain circumstances and after careful counselling.

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  1. Abteilung für Gynäkologische Endokrinologie und Fertilitätsstörungen der Universitäts-Frauenklinik Heidelberg

    M. von Wolff, S. Eisenhardt & T. Strowitzki

  2. Abteilung für Gynäkologische Endokrinologie und Fertilitätsstörungen der Universitäts-Frauenklinik Heidelberg, Vossstraße 9, 69115 , Heidelberg

    M. von Wolff

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  1. M. von Wolff
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  3. T. Strowitzki
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Correspondence to M. von Wolff.

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von Wolff, M., Eisenhardt, S. & Strowitzki, T. Ovarielle Protektion und Erhalt der Fertilität im Rahmen der Therapie gynäkologischer Malignome bei Kinderwunsch. Gynäkologische Endokrinologie 3, 107–114 (2005). https://doi.org/10.1007/s10304-005-0107-8

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  • DOI: https://doi.org/10.1007/s10304-005-0107-8

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