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Le Coriolus versicolor: le plus puissant immunostimulant connu. Utilisation en cancérologie, contre les virus et pour toute stimulation immunitaire

Coriolus versicolor: the most powerful immunostimulating agent. Interest in oncology, against virus and for all types of immunostimulation

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  • Mycothérapie
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Phytothérapie

Résumé

Le Coriolus versicolor (CV) est le chef de file des immunostimulants. Il est utilisé avec succès comme adjuvant des radiochimiothérapies dans les cancers digestifs, ORL, du sein, du système nerveux, de la peau, du poumon, du foie... Il stimule la voie TH1 avec libération d’IL2, de TNF et d’interférons. Il empêche la dégradation de l’immunité vers la voie TH2 (allergie) ou TH3 (auto-immunité). En corollaire, il peut éviter les effets secondaires inhérents à la vaccination (stimulation excessive TH2 ou TH3). Le CV possède des propriétés antivirales bien établies contre l’herpès et le papillomavirus. Son activité anti-VIH constatée in vitro reste à prouver chez les patients. C’est un excellent hépatoprotecteur, propriété précieuse chez les patients qui subissent une chimiothérapie.

Abstract

Coriolus versicolor (CV) is the strongest immunostimulating agent currently used. It is successfully added to protocoles including radio-chimiotherapy regimens in digestive, upper respiratory, breast, nervous system, skin, lung or hepatic cancers. It stimulates immunity (TH1) with IL2, TNF or interferons release. It hinders the switch to TH2 (allergy) or TH3 (auto-immunity). It therefore may limitate the adverse reactions related to vaccination. (excess in TH2 or TH3 stimulation). CV is a potent antiviral agent against herpes and papillomavirus. Its anti-HIV activity observed in vitro requires further clinical investigations. It is an efficacious hepatoprotective agent, which is quite usefull in patients undergoing chemotherapy and receiving many medications.

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    B. Donatini

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Donatini, B. Le Coriolus versicolor: le plus puissant immunostimulant connu. Utilisation en cancérologie, contre les virus et pour toute stimulation immunitaire. Phytothérapie 8, 255–258 (2010). https://doi.org/10.1007/s10298-010-0562-9

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