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2-Keto acids based biosynthesis pathways for renewable fuels and chemicals

  • Metabolic Engineering and Synthetic Biology
  • Published:
Journal of Industrial Microbiology & Biotechnology

Abstract

Global energy and environmental concerns have driven the development of biological chemical production from renewable sources. Biological processes using microorganisms are efficient and have been traditionally utilized to convert biomass (i.e., glucose) to useful chemicals such as amino acids. To produce desired fuels and chemicals with high yield and rate, metabolic pathways have been enhanced and expanded with metabolic engineering and synthetic biology approaches. 2-Keto acids, which are key intermediates in amino acid biosynthesis, can be converted to a wide range of chemicals. 2-Keto acid pathways were engineered in previous research efforts and these studies demonstrated that 2-keto acid pathways have high potential for novel metabolic routes with high productivity. In this review, we discuss recently developed 2-keto acid-based pathways.

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Acknowledgments

This work was supported by University of California–Davis startup fund and the Hellman fellowship to S.A. G.M.R. was supported by a US National Institutes of Health Biotechnology Training Grant Fellowship (T32-GM008799) and a Sloan Fellowship. Y.T. was supported by Japan Society for the Promotion of Science postdoctoral fellowship for research abroad.

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  1. Department of Chemistry, University of California-Davis, Davis, CA, USA

    Yohei Tashiro, Gabriel M. Rodriguez & Shota Atsumi

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  1. Yohei Tashiro
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Correspondence to Shota Atsumi.

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Tashiro, Y., Rodriguez, G.M. & Atsumi, S. 2-Keto acids based biosynthesis pathways for renewable fuels and chemicals. J Ind Microbiol Biotechnol 42, 361–373 (2015). https://doi.org/10.1007/s10295-014-1547-8

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