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Prospecting genomes for lasso peptides

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  • Published:
Journal of Industrial Microbiology & Biotechnology

Abstract

Genome mining has unlocked a veritable treasure chest of natural compounds. However, each family of natural products requires a genome-mining approach tailored to its unique features to be successful. Lasso peptides are ribosomally synthesized and posttranslationally modified products with a unique three-dimensional structure. Advances in the understanding of these molecules have informed the design of strategies to identify new members of the class in sequenced genomes. This review presents the bioinformatic methods used to discover novel lasso peptides and describes how such analyses have afforded insights into the biosynthesis and evolution of this peptide class.

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Acknowledgments

Research in our laboratory on lasso peptides has been supported by the NSF and Project X. AJL is a DuPont Young Professor and a Sloan Research Fellow.

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Authors and Affiliations

  1. 207 Hoyt Laboratory, Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, 08544, USA

    Mikhail O. Maksimov & A. James Link

  2. Department of Molecular Biology, Princeton University, Princeton, NJ, USA

    A. James Link

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  1. Mikhail O. Maksimov
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  2. A. James Link
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Correspondence to A. James Link.

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Maksimov, M.O., Link, A.J. Prospecting genomes for lasso peptides. J Ind Microbiol Biotechnol 41, 333–344 (2014). https://doi.org/10.1007/s10295-013-1357-4

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