Abstract
Glycosylation is one of the most important post-modification processes of small molecules and enables the parent molecule to have increased solubility, stability, and bioactivity. Enzyme-based glycosylation has achieved significant progress due to advances in protein engineering, DNA recombinant techniques, exploitation of biosynthetic gene clusters of natural products, and computer-based modeling programs. Our report summarizes glycosylation data that have been published within the past five years to provide an overall review of current progress. We also present the future trends and perspectives for glycosylation.
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Acknowledgments
This study was supported by the Intelligent Synthetic Biology Center of Global Frontier Project funded by the Ministry of Education, Science and Technology (2011-0031960) and by the grant from the Next-Generation BioGreen 21 Program (JKS: PJ0094832), Rural Development Administration, and Republic of Korea.
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Thuan, N.H., Sohng, J.K. Recent biotechnological progress in enzymatic synthesis of glycosides. J Ind Microbiol Biotechnol 40, 1329–1356 (2013). https://doi.org/10.1007/s10295-013-1332-0
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DOI: https://doi.org/10.1007/s10295-013-1332-0