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Nonpharmacological treatment of reflex syncope

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Abstract.

Reflex syncope is a common medical problem. Vasovagal reflex syncope is the most frequent form. Although the prognosis of the disorder is excellent, it may impose substantial changes in life style and cause profound psychological distress. Thus, management of this disorder is an important issue. This chapter, based on a review of the literature and the authors’ clinical experience, encompasses the non-pharmacological measures used in the management of reflex syncope.

The cornerstone of the non-pharmacological management of patients with reflex syncope is education and reassurance regarding the benign nature of the condition. Patients should be instructed to avoid potential triggers. A tilt table test can be employed to teach the patient to recognize early premonitory symptoms. There are several physical maneuvers (e. g., leg crossing, muscle tensing and squatting) that are effective in combating orthostatic intolerance. For the majority of patients this approach is adequate.

Patients with frequent attacks of reflex syncope are advised to increase their dietary salt intake. Exercise training also increases orthostatic tolerance. In highly motivated patients with recurrent syncope, raising the head of the bed to permit gravitational exposure during sleep and prolonged periods of enforced maintenance of the upright posture (tilt-training) can be considered. Preliminary data suggest that water drinking may improve orthostatic tolerance. Abdominal belts may also be effective in highly symptomatic subjects with reflex syncope.

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References

  1. Abe H, Kohshi K, Nakashima Y (2003) Efficacy of orthostatic self-training in medically refractory neurocardiogenic syncope. Clin Exp Hypertens 25:487–493

    Article  PubMed  Google Scholar 

  2. Allan SC, Taylor CG, Hall VE (1945) A study of orthostatic insufficiency by the tiltboard method. Am J Physiology 143:11–20

    Google Scholar 

  3. Arbeille P, Fomina G, Achaibou F, Pottier J, Kotovskaya A (1995) Cardiac and vascular adaptation to 0 g with and without thigh cuffs (Antares 14 and Altair 21 day Mir spaceflights). Acta Astronaut 36:753–762

    Article  CAS  PubMed  Google Scholar 

  4. Bouvette CM, McPhee BR, Opfer-Gehrking TL, Low PA (1996) Role of physical countermaneuvers in the management of orthostatic hypotension: efficacy and biofeedback augmentation. Mayo Clin Proc 71:847–853

    CAS  PubMed  Google Scholar 

  5. Brignole M, Alboni P, Benditt DG, Bergfeldt l, Blanc JJ, Bloch Thomsen PE, Dijk JGv, Fitzpatrick A, Hohnloser S, Janousek J, Kapoor WN, Kenny RA, Kulakowski P, Moya A, Raviele A, Sutton R, Theodorakis G, Wieling W (2001) Guidelines on management (diagnosis and treatment) of syncope. Eur Heart J 22:1256–1306

    Article  PubMed  Google Scholar 

  6. Brignole M, Croci F, Menozzi C, Solano A, Donateo P, Oddone D, Puggioni E, Lolli G (2002) Isometric arm counterpressure maneuvers to abort impending vasovagal syncope. J Am Coll Cardiol 40:2054–2060

    Google Scholar 

  7. Cariga P, Mathias CJ (2001) Haemodynamics of the pressor effect of oral water in human sympathetic denervation due to autonomic failure. Clin Sci 101:313–319

    Article  CAS  Google Scholar 

  8. Custaud MA, Millet C, Frutoso J, Maillet A, Gauquelin G, Gharib C, Fortrat JO (2000) No effect of venoconstrictive thigh cuffs on orthostatic hypotension induced by head-down bed rest. Acta Physiol Scand 170:77–85

    Article  CAS  PubMed  Google Scholar 

  9. Dambrink JH, Imholz BP, Karemaker JM, Wieling W (1991) Postural dizziness and transient hypotension in two healthy teenagers. Clin Auton Res 1:281–287

    CAS  PubMed  Google Scholar 

  10. Denq JC, Opfer-Gehrking TL, Giuliani M, Felten J, Convertino VA, Low PA (1997) Efficacy of compression of different capacitance beds in the amelioration of orthostatic hypotension. Clin Auton Res 7:321–326

    CAS  PubMed  Google Scholar 

  11. Di Girolamo E, Di Iorio C, Leonzio L, Sabatini P, Barsotti A (1999) Usefulness of a tilt training program for the prevention of refractory neurocardiogenic syncope in adolescents: A controlled study. Circulation 100:1798–1801

    CAS  PubMed  Google Scholar 

  12. Dijk N van, Harms MP, Linzer M, Wieling W (2000) Treatment of vasovagal syncope: pacemaker or crossing legs. Clin Auton Res 10:347–349

    PubMed  Google Scholar 

  13. Dijk N van, Krediet CT, Bruin IGJMd, Lieshout JJv, Wieling W (2003) Physical counterpressure maneuvers to prevent and abort vasovagal syncope: a novel effective treatment? In: Raviele A (ed) Cardiac Arrhythmias. Springer-Verlag, pp 633–639

  14. Dijk N van, Velzeboer SCJM, Destree-Vonk A, Linzer M, Wieling W (2001) Psychological treatment of malignant vasovagal syncope due to blood phobia. Pacing Clin Electrophysiol 24:122–124

    Article  PubMed  Google Scholar 

  15. Ector H, Reybrouck T, Heidbuchel H, Gewillig M, Van de Werf F (1998) Tilt training: a new treatment for recurrent neurocardiogenic syncope and severe orthostatic intolerance. Pacing Clin Electrophysiol 21:193–196

    CAS  PubMed  Google Scholar 

  16. El-Sayed H, Hainsworth R (1995) Relationship between plasma volume, carotid baroreceptor sensitivity and orthostatic tolerance. Clin Sci (Colch.) 88:463–470

    PubMed  Google Scholar 

  17. El-Sayed H, Hainsworth R (1996) Salt supplement increases plasma volume and orthostatic tolerance in patients with unexplained syncope. Heart 75:134–140

    CAS  PubMed  Google Scholar 

  18. Engel GL, Romano J (1947) Studies of syncope: IV. Biologic interpretation of vasodepressor syncope. Psychosom Med 9:288–294

    Google Scholar 

  19. Fenton AM, Hammill SC, Rea RF, Low PA, Shen WK (2000) Vasovagal syncope. Ann Intern Med 133:714–725

    CAS  PubMed  Google Scholar 

  20. Evaluation of tilt training in the treatment of recurrent neurally mediated syncope. Europace Supplements 2:B195

  21. Grimm W, Degenhardt M, Hoffman J, Menz V, Wirths A, Maisch B (1997) Syncope recurrence can better be predicted by history than by head-up tilt testing in untreated patients with suspected neurally mediated syncope. Eur Heart J 18:1465–1469

    CAS  PubMed  Google Scholar 

  22. Hainsworth R (2000) Head-up sleeping for posturally related syncope. Clin Auton Res 10(4):225–226

    Google Scholar 

  23. Harkel ADt, Lieshout JJv, Wieling W (1994) Effects of leg muscle pumping and tensing on orthostatic arterial pressure: a study in normal subjects and patients with autonomic failure. Clin Sci (Lond) 87:553–558

    PubMed  Google Scholar 

  24. Hellstrom K, Fellenius J, Ost LG (1996) One versus five sessions of applied tension in the treatment of blood phobia. Behav Res Ther 34:101–112

    Article  CAS  PubMed  Google Scholar 

  25. Henry R, Rowe J, O’Mahony D (1999) Haemodynamic analysis of efficacy of compression hosiery in elderly fallers with orthostatic hypotension. Lancet 354:45–46

    Article  CAS  PubMed  Google Scholar 

  26. Hill L (1895) The influence of the force of gravity in the circulation of the blood. J Physiol 18:15–53

    Google Scholar 

  27. Imholz BPM, Wieling W, Montfrans GAv, Wesseling KH (1998) Fifteen years experience with finger arterial pressure monitoring: assessment of the technology. Cardiovasc Res 38:605–616

    Article  CAS  PubMed  Google Scholar 

  28. Jordan J, Shannon JR, Black BK, Ali Y, Farley M, Costa F, Diedrich A, Robertson RM, Biaggioni I, Robertson D (2000) The Pressor Response to Water Drinking in Humans. A Sympathetic Reflex? Circulation 101:504–509

    CAS  PubMed  Google Scholar 

  29. Jordan J, Shannon JR, Grogan E, Biaggioni I, Robertson D (1999) A potent pressor response elicited by drinking water. Lancet 353:723

    Article  CAS  PubMed  Google Scholar 

  30. Kapoor WN (2000) Syncope. N Engl J Med 343:1856–1862

    Article  CAS  PubMed  Google Scholar 

  31. Khurana RK, Lynch JJ, Craig FW (1997) A novel psychophysiological treatment for vasovagal syncope. Clin Auton Res 7:191–197

    CAS  PubMed  Google Scholar 

  32. Kozak MJ (1985) The psychophysiological process of therapy in a case of injury-scene-elicited fainting. J Behav Ther & Exp Psychiat 16:139–145

    Google Scholar 

  33. Krediet CT (2002) Initial orthostatic hypotension in a 37-year old horse rider. Clin Auton Res 12:202

    Article  Google Scholar 

  34. Krediet CT, Wieling W (2003) Manoeuvres to combat vasovagal syncope. Europace 5:303

    Article  PubMed  Google Scholar 

  35. Krediet CTP, van Dijk N, Linzer M, van Lieshout JJ, Wieling W (2002) Management of Vasovagal Syncope: Controlling or Aborting Faints by Leg Crossing and Muscle Tensing. Circulation 106:1684–1689

    Article  PubMed  Google Scholar 

  36. Lieshout JJv, Harkel ADt, Wieling W (1992) Physical manoeuvres for combating orthostatic dizziness in autonomic failure. Lancet 339:897–898

    Article  PubMed  Google Scholar 

  37. Lieshout JJv, Pott F, Madsen PL, Goudoever Jv, Secher NH (2001) Muscle Tensing During Standing: Effects on Cerebral Tissue Oxygenation and Cerebral Artery Blood Velocity. Stroke 32:1546–1551

    PubMed  Google Scholar 

  38. Lindgren KN, Kraft D, Ballard RE, Tucker A, Hargens AR (1998) Venoconstrictive thigh cuffs impede fluid shifts during simulated microgravity. Aviat Space Environ Med 69:1052–1058

    CAS  PubMed  Google Scholar 

  39. Linzer M, Pontinen M, Gold DT, Divine GW, Felder A, Brooks WB (1991) Impairment of physical and psychosocial function in recurrent syncope. J Clin Epidemiol 44:1037–1043

    Article  CAS  PubMed  Google Scholar 

  40. Lu CC, Diedrich A, Tung CS, Paranjape SY, Harris PA, Byrne DW, Jordan J, Robertson D (2003) Water ingestion as prophylaxis against syncope. Circulation 108:2660–2665

    Article  PubMed  Google Scholar 

  41. Matsnev EI, Yakovleva IY, Tarasov IK, Alekseev VN, Kornilova LN, Mateev AD, Gorgiladze GI (1983) Space motion sickness: phenomenology, countermeasures, and mechanisms. Aviat Space Environ Med 54:312–317

    CAS  PubMed  Google Scholar 

  42. Mayerson HS, Burch GE (1940) Relationships of tissue (subcutaneous and intramuscular) and venous pressures to syncope induced in man by gravity. Am J Physiol 128:258–269

    Google Scholar 

  43. Mtinangi BL, Hainsworth R (1998) Early effects of oral salt on plasma volume, orthostatic tolerance, and baroreceptor sensitivity in patients with syncope. Clin Auton Res 8:231–235

    CAS  Google Scholar 

  44. Mtinangi BL, Hainsworth R (1998) Increased orthostatic tolerance following moderate exercise training in patients with unexplained syncope. Heart 80:596–600

    CAS  PubMed  Google Scholar 

  45. Mtinangi BL, Hainsworth R (1999) Effect of moderate excercise training on plasma volume, baroreceptor sensitivity and orthostatic tolerance in healthy subjects. Exp Physiol 84:121–130

    CAS  PubMed  Google Scholar 

  46. Newton JL, Kenny RA, Baker CR (2003) Cognitive behavioural therapy as a potential treatment for vasovagal/neurocardiogenic syncope–a pilot study. Europace 5:299–301

    Article  CAS  PubMed  Google Scholar 

  47. Omboni S, Smit AA, Lieshout JJv, Settels JJ, Langewouters GJ, Wieling W (2001) Mechanisms underlying the impairment in orthostatic tolerance after nocturnal recumbency in patients with autonomic failure. Clin Sci (Colch.) 101:619–620

    Article  PubMed  Google Scholar 

  48. Ost LG, Hellstrom K, Kaver A (1992) One versus five sessions of exposure in the treatment of injection phobia. Behavior Therapy 23:263–282

    Google Scholar 

  49. Ost LG, Sterner U (1987) Applied tension. A specific behavioral method for treatment of blood phobia. Behav Res Ther 25:25–29

    Article  CAS  PubMed  Google Scholar 

  50. Piorry PA (1826) Recherches sur l’influence de la pesanteur sur le cours du sang; diagnostic de la syncope et de l’apoplexie; cause et traitement de la syncope. Arch Gen Med 12:527–544

    Google Scholar 

  51. Reybrouck T, Heidbuchel H, Van De WF, Ector H (2002) Long-term follow-up results of tilt training therapy in patients with recurrent neurocardiogenic syncope. Pacing Clin Electrophysiol 25:1441–1446

    Article  PubMed  Google Scholar 

  52. Rose MS, Koshman ML, Spreng S, Sheldon R (2000) The relationship between health-related quality of life and frequency of spells in patients with syncope. J Clin Epidemiol 53:1209–1216

    Article  CAS  PubMed  Google Scholar 

  53. Sabin N (2001) The use of applied tension and cognitive therapy to manage syncope (common faint) in an older adult. Aging Ment Health 5:92–94

    Article  CAS  PubMed  Google Scholar 

  54. Saul JP (1999) Syncope: etiology, management, and when to refer. J South Carolina Med Assoc 95:385–387

    CAS  Google Scholar 

  55. Schroeder C, Bush V, Norcliffe L, Luft F, Tank J, Jordan J, Hainsworth R (2002) Water drinking acutely improves orthostatic tolerance in healthy subjects. Circulation 106:2806–2811

    Article  PubMed  Google Scholar 

  56. Sewall H (1916) The clinical relations of gravity, posture and circulation. Am J Med Sci 151:491–505

    Google Scholar 

  57. Shannon JR, Diedrich A, Biaggioni I, Tank J, Robertson RM, Robertson D, Jordan J (2002) Water Drinking as a Treatment for Orthostatic Syndromes. Am J Med 112:355–360

    Article  PubMed  Google Scholar 

  58. Sharpey-Schafer EP (1956) Emergencies in general practice. Syncope. Br Med J 1:506–509

    Google Scholar 

  59. Sheldon R, Rose S (2001) Components of clinical trials for vasovagal syncope. Europace 3:233–240

    Article  CAS  PubMed  Google Scholar 

  60. Sheldon R, Rose S, Flanagan P, Koshman ML, Killam S (1996) Risk factors for syncope recurrence after a positive tilt-table test in patients with syncope. Circulation 93:973–981

    CAS  PubMed  Google Scholar 

  61. Shichiri M, Tanaka H, Takaya R, Tamai H (2002) Efficacy of high sodium intake in a boy with instantaneous orthostatic hypotension. Clin Auton Res 12:47–50

    Article  PubMed  Google Scholar 

  62. Smit AAJ, Wieling W, Fujimura O, Denq JC, Opfer-Gehrking TL, Akario M, Karemaker JM, Low PA (2004) Use of lower abdominal compression to combat orthostatic hypotension in patients with autonomic failure. Clin Auton Res (in press)

  63. Smit AAJ, Halliwill JR, Low PA, Wieling W (1999) Pathophysiological basis of orthostatic hypotension in autonomic failure. J Physiol 519:1–10

    Article  CAS  PubMed  Google Scholar 

  64. Soteriades ES, Evans JC, Larson MG, Chen MH, Chen L, Benjamin EJ, Levy D (2002) Incidence and Prognosis of Syncope. N Engl J Med 347:878–885

    Article  PubMed  Google Scholar 

  65. Sutton R (1999) Vasovagal syncope: prevalence and presentation. An algorithm of management in the aviation environment. Eur Heart J (Supplement 1):D109–D113

    Google Scholar 

  66. Sutton R, Bloomfield DM (1999) Indications, Methodology, and Classification of Results of Tilt-Table Testing. Am J Cardiol 84:10Q–19Q

    Article  CAS  PubMed  Google Scholar 

  67. Tanaka H, Yamaguchi H, Tamai H (1997) Treatment of orthostatic intolerance with inflatable abdominal band (letter). Lancet 349:175

    Article  CAS  Google Scholar 

  68. Thijs RD, Reijntjes RH, van Dijk JG (2003) Water drinking as a potential treatment for idiopathic exercise-related syncope. A case report. Clin Auton Res 13:103–105

    Article  PubMed  Google Scholar 

  69. Vogt FB, Johnson PC (1967) Effectiveness of extremity cuffs or leotards in preventing or controlling the cardiovascular deconditioning of bedrest. Aerospace Medicine 38:702–707

    CAS  PubMed  Google Scholar 

  70. White WD, Sheldon RS, Ritchie DA (2003) Learning needs of patients with vasovagal syncope. Can J Cardiovasc Nurs 13:26–30

    PubMed  Google Scholar 

  71. Wieling W, Lieshout JJv, Hainsworth R (2002) Extracellular fluid volume expansion in patients with posturally related syncope. Clin Auton Res 12:242–249

    Article  CAS  PubMed  Google Scholar 

  72. Wieling W, Lieshout JJv, Leeuwen AMv (1993) Physical manoeuvres that reduce postural hypotension in autonomic failure. Clin Auton Res 3:57–65

    CAS  PubMed  Google Scholar 

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Correspondence to Wouter Wieling MD, PhD.

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Wieling, W., Colman, N., Krediet, C.T.P. et al. Nonpharmacological treatment of reflex syncope. Clin Auton Res 14 (Suppl 1), i62–i70 (2004). https://doi.org/10.1007/s10286-004-1009-x

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