Skip to main content

Advertisement

Log in

Automated Detection and Grading of Diabetic Maculopathy in Digital Retinal Images

  • Published:
Journal of Digital Imaging Aims and scope Submit manuscript

Abstract

Diabetic maculopathy is one of the retinal abnormalities in which a diabetic patient suffers from severe vision loss due to the affected macula. It affects the central vision of the person and causes blindness in severe cases. In this article, we propose an automated medical system for the grading of diabetic maculopathy that will assist the ophthalmologists in early detection of the disease. The proposed system extracts the macula from digital retinal image using the vascular structure and optic disc location. It creates a binary map for possible exudate regions using filter banks and formulates a detailed feature vector for all regions. The system uses a Gaussian Mixture Model-based classifier to the retinal image in different stages of maculopathy by using the macula coordinates and exudate feature set. The evaluation of proposed system is performed by using publicly available standard retinal image databases. The results of our system have been compared with other methods in the literature in terms of sensitivity, specificity, positive predictive value and accuracy. Our system gives higher values as compared to others on the same databases which makes it suitable for an automated medical system for grading of diabetic maculopathy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

References

  1. Causes and risk factors of diabetic retinopathy. United States National Library of Medicine. 15 September 2009

  2. Iwasaki M, Inomara H: “Relation between superficial capillaries and fovea structures in the human retina”, J Investigative Visual Ophthalmology 27:1698–1705,1986

    CAS  Google Scholar 

  3. Niemeijer M, Ginneken BV, Russell SR, Suttorp-Schulten MS, Abrmoff MD: Automated detection and differentiation of drusen, exudates, and cotton-wool spots in digital color fundus photographs for diabetic retinopathy diagnosis. Invest Ophthalmology Vis Sci 48(5):2260–2267,2007

    Article  Google Scholar 

  4. Zhang X, Chutatape O: Top down and bottom up strategies in lesion detection of background diabetic retinopathy. IEEE Computer Society Conference on Computer Vision and Pattern Recognition, 2005, CVPR 2005, 2: pp 422–428

  5. Acharya UR, Chua CK, Ng EYK, Yu W, Chee C: Application of higher order spectra for the identification of diabetes retinopathy stages. J Med Systems 32:481–488,2008

    Article  Google Scholar 

  6. Sinthanayothin C, Boyce JF, Cook HL, Williamson TH: Automated localisation of the optic disc, fovea, and retinal blood vessels from digital colour fundus images. British J Ophthalmology 83:902–910,1999

    Article  CAS  Google Scholar 

  7. Tan NM, Wong DWK, Liu J, Ng WJ, Zhang Z, Lim JH, Tan Z, Tang Y, Li H, Lu S, Wong TY: Automatic detection of the macula in the retinal fundus image by detecting regions with low pixel intensity, International Conference on Biomedical and Pharmaceutical Engineering, ICBPE '09, pp. 1–5, 2009, IEEE, Singapore

  8. Elshahawy MS, ElAntably A, Fawzy N, Samir K, Hunter M, Fahmy AS: Segmentation of diabetic macular edema in fluorescein angiograms. IEEE International Symposium on Biomedical Imaging: From Nano to Macro, pp. 661–664, 2011, IEEE, Chicago, IL

  9. Lim ST, Zaki WMDW, Hussain A, Lim SL, Kusalavan S: Automatic classification of diabetic macular edema in digital fundus images. 2011 IEEE Colloquium on Humanities, Science and Engineering (CHUSER), pp. 265–269, 2011, IEEE, Penang, Malaysia

  10. Deepak KS, Sivaswamy J: Automatic assessment of macular edema from color retinal images. IEEE Transactions on Medical Imaging 31(3):766–776,2012

    Article  PubMed  Google Scholar 

  11. Osareh A, Mirmehdi M, Thomas B, Markham R: Automatic recognition of exudative maculopathy using fuzzy C-means clustering and neural networks. Proceedings of Medical Image Understanding and Analysis Conference, pp. 49–52, 2001

  12. Siddalingaswamy PC,Prabhu KG: Automatic grading of diabetic maculopathy severity levels. Proceedings of 2010 International Conference on Systems in Medicine and Biology, pp. 331–334, 2010

  13. Tariq A, Akram MU: An automated system for colored retinal image background and noise segmentation. IEEE Symposium on Industrial Electronics and Applications (ISIEA 2010), pp. 405–409, 3rd–5th October 2010, Penang, Malaysia

  14. Akram MU, Tariq A, Anjum MA, Javed MY: Automated detection of exudates in colored retinal images for diagnosis of diabetic retinopathy. OSA J Applied Optics 51(20):4858–4866,2012

    Article  CAS  Google Scholar 

  15. Gonzalez RC, Woods RE: Digital Image Processing, 2nd edition. Prentice Hall, Upper Saddle River, 2002

    Google Scholar 

  16. Akram MU, Khan A, Iqbal K, Butt WH: Retinal images: optic disk localization and detection, ICIAR 2010, Part II, LNCS 6112, pp. 40–49, 2010

  17. Mubbashar M, Usman A, Akram MU: “Automated system for macula detection in digital retinal images”. International Conference on Information and Communication Technologies (ICICT), pp. 1–5, 2011.

  18. Akram MU, Khan SA: Multilayered thresholding-based blood vessel segmentation for screening of diabetic retinopathy, Engineering with Computer (EWCO), 2012, doi:10.1007/s00366-011-0253-7

  19. Theodoridis S, Koutroumbas K: Pattern Recognition, 1st ed. Burlington, MA: Academic, 1999

    Google Scholar 

  20. Duda RO, Hart PE, Stork DG: Pattern Classification. New York: Wiley, 2001

    Google Scholar 

  21. MESSIDOR: http://messidor.crihan.fr/index-en.php. Accessed 10 January 2013.

  22. Hoover, STARE database, http://www.ces.clemson.edu/~ahoover/stare/. Accessed 10 January 2013.

  23. Sagar AV, Balasubramanian S, Chandrasekaran V: Automatic detection of anatomical structures in digital fundus retinal images. Conference on Machine Vision Applications pp. 483–486, 2007

  24. Lu S, Lim JH: Automatic macula detection from retinal images by a line operator. Proceedings of 2010 IEEE 17th International Conference on Image Processing, pp. 4073–4076, 2010

  25. Nayak J, Bhat PS, Acharya UR, Lim CM, Kagathi M: Automated identification of diabetic retinopathy stages using digital fundus images, J Medical Systems 32:107–115,2008

    Article  Google Scholar 

  26. Reza AW, Eswaran C, Dimyati K: Diagnosis of diabetic retinopathy: automatic extraction of optic disc and exudates from retinal images using marker controlled watershed transformation. J Medical Systems 35(6):1491–1501,2011

    Article  Google Scholar 

  27. Yazid H, Arof H, Mohd Isa H: Automated Identification of exudates and optic disc based on inverse surface thresholding, J Medical Systems 36(3):1997–2204,2012

    Article  Google Scholar 

  28. Walter T, Klein JC, Massin P, Erginay A: A contribution of image processing to the diagnosis of diabetic retinopathy detection of exudates in color fundus images of the human retina. IEEE Transactions on Medical Imaging 21(10):1236–1243,2002

    Article  PubMed  Google Scholar 

  29. Alireza O, Shadgar B, Markham R: A computational-intelligence-based approach for detection of exudates in diabetic retinopathy images. IEEE Transactions on Information Technology in Biomedicine 13(4):535–545,2009

    Article  Google Scholar 

  30. Akram MU, Khan MU: Automated detection of dark and bright lesions in retinal images for early detection of diabetic retinopathy. J Medical Systems 36(5):3151–3162,2012

    Article  Google Scholar 

  31. Aquino A, Gegundez ME, Marin D: Automated optic disc detection in retinal images of patients with diabetic retinopathy and risk of macular edema. International J Biological Life Sciences 8(2):87–92,2012

    Google Scholar 

Download references

Conflict of Interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anam Tariq.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tariq, A., Akram, M.U., Shaukat, A. et al. Automated Detection and Grading of Diabetic Maculopathy in Digital Retinal Images. J Digit Imaging 26, 803–812 (2013). https://doi.org/10.1007/s10278-012-9549-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10278-012-9549-4

Keywords

Navigation