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Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases: Japanese prospective multicentre observational study

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A Correction to this article was published on 20 February 2018

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Abstract

Atherosclerosis, a chronic inflammatory disease in arterial blood vessels, is one of the major causes of death in worldwide. Meanwhile, periodontal disease is a chronic inflammatory disease caused by infection with periodontal pathogens such as P. gingivalis (Porphyromonas gingivalis). Several studies have reported association between periodontal infection and atherosclerosis, but direct investigation about the effects of periodontal treatment on atherosclerosis has not been reported. We have planned Japanese local clinics to determine the relationship between periodontal disease and atherosclerosis under collaborative with medical and dental care. A prospective, multicentre, observational study was conducted including 38 medical patients with lifestyle-related diseases in the stable period under consultation at participating medical clinics and 92 periodontal patients not undergoing medical treatment but who were consulting at participating dental clinics. Systemic and periodontal examinations were performed before and after periodontal treatment. At baseline, LDL-C (low-density lipoprotein cholesterol) levels and percentage (%) of mobile teeth were positively related to plasma IgG (immunoglobulin) antibody titer against P. gingivalis with multivariate analysis. Corresponding to improvements in periodontal clinical parameters after treatment, right and left max IMT (maximum intima-media thickness) levels were decreased significantly after treatment (SPT-S: start of supportive periodontal therapy, SPT-1y: at 1 year under SPT, and SPT-3y: at 3 years under SPT). The present study has clarified our previous univariate analysis results, wherein P. gingivalis infection was positively associated with progression of atherosclerosis. Thus, routine screening using plasma IgG antibody titer against P. gingivalis and periodontal treatment under collaborative with medical and dental care may prevent cardiovascular accidents caused by atherosclerosis.

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Change history

  • 20 February 2018

    Unfortunately, in Table-5 of the original article, the parameter in the 5th row was published incorrectly as “LDL-C (mg/dL)”. The correct parameter should read as “HDL-C (mg/dL)”.

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Acknowledgements

This study was supported by Grant-in-planning for Advanced Research (H22) from Japanese Society of Periodontology. Periodontitis and Atherosclerosis Project–Tokyo and Chiba Consortiums include: Kiyotaka Fujii (Kashiwado Memorial Foundation Port square Kashiwado Clinic, Chiba), Tooru Hanai (Kensei Clinic, Chiba), Kouya Honda (Honda Medical Clinic, Tokyo), Yoshichika Horiuchi (Horiuchi Dental Clinic, Tokyo), Hiroshi Inoue (Tsubasa Dental Clinic, Tokyo), Kiyoo Ishige (Tendai Dental Clinic, Chiba), Shinichi Itoh (Ito Clinic, Tokyo), Sachiho Iwatsuka (Hotaruno Dental Clinic, Chiba), Tomoko Kakugawa (Tomiya Central Hospital, Miyagi), Hideto Komai (Eiken Medical Dental Clinic, Tokyo), Chikara Morimoto (Morimoto Dental Office, Tokyo), Mitsutaka Motoyoshi (Memorial Hospital of Kazusa, Tokyo), Masato Nakamura (Nakamura Clinic, Chiba), Mikiko Niida (Naganawa Dental Clinic, Chiba), Ryuji Numaguchi (Numaguchi Dental Office, Tokyo), Kiyomi Oono (Oono Dental Clinic, Chiba), Hidetoshi Sakai (Sakai Dental Clinic, Chiba), Yasunari Sakomura (Sakomura Medical Clinic, Tokyo), Takaaki Shinohara (Shinohara Dental Clinic, Tokyo), Yuichi Takakaze (Takakaze Dental Clinic, Tokyo), Yukio Tsuruta (Tsuruta Clinic, Tokyo), Daigaku Uchida (Hotaruno Central Internal Medicine, Chiba), Norihide Ueno (Ushigomekagurazaka Dental Office, Tokyo), and Osamu Yasuda (Clinic Yasuda, Tokyo).

Author information

Author notes

  1. Kazuo Harai

    Present address: Harai Dental Office, 2-20-17-1F Sangenjaya, Setagaya-ku, Tokyo, 154-0024, Japan

Authors and Affiliations

  1. Division of Periodontology, Department of Oral Function & Restoration, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka, Kanagawa, 238-8580, Japan

    Chieko Kudo & Masato Minabe

  2. Sekimachi Medical Clinic, 5-6-1 Sekimachikita, Nerima-ku, Tokyo, 177-0051, Japan

    Wee Soo Shin

  3. Katsutadai Dental Clinic, 1-3-7 Katsutadai, Yachiyo-shi, Chiba, 276-0024, Japan

    Nobuhiro Sasaki

  4. Matsumoto Dental Office, 2-6-12-1F, Senzoku, Meguro-ku, Tokyo, 152-0012, Japan

    Kazuo Harai

  5. Mejiro Medical-Road Dental Clinic, 2-5-27 Mejiro, Toshima-ku, Tokyo, 171-0031, Japan

    Kai Kato

  6. Tomiya Central Hospital, 2-1-6 Kamisakuragi, Tomiya-machi, Kurokawa-gun, Miyagi, 981-3328, Japan

    Hiroaki Seino

  7. Goke Dental Clinic, 5-41-17 Higashioizumi, Nerima-ku, Tokyo, 178-0063, Japan

    Eiji Goke

  8. Kyodo Dental Clinic, 1-32-2 Yoyogi, Shibuya-ku, Tokyo, 151-0053, Japan

    Takemasa Fujino

  9. Misaki Internal Medicine Clinic, 6-44-9 Futawa Higashi, Funabashi-shi, Chiba, 274-0805, Japan

    Nobuichi Kuribayashi

  10. Pearce Clinic, 7-20-5 Konakadai, Inage-ku Chiba-shi, Chiba, 263-0043, Japan

    Youko Onuki Pearce

  11. Taira Clinic, 1-36-11 Katsutadai Yachiyo-shi, Chiba, 276-0023, Japan

    Masato Taira

  12. Matsushima Dental Clinic, 2-6-12-1F, Senzoku, Meguro-ku, Tokyo, 152-0012, Japan

    Ryoji Matsushima

  13. Bunkyo Do-ri Dental Clinic, 2-4-1, Anagawa, Inage-ku Chiba-shi, Chiba, 263-0024, Japan

    Masato Minabe

  14. Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan

    Shogo Takashiba

Authors
  1. Chieko Kudo
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  2. Wee Soo Shin
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  3. Nobuhiro Sasaki
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  4. Kazuo Harai
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  5. Kai Kato
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  6. Hiroaki Seino
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  7. Eiji Goke
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  8. Takemasa Fujino
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  12. Ryoji Matsushima
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  13. Masato Minabe
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Consortia

Periodontitis and Atherosclerosis Project-Tokyo and Chiba Consortiums

  • Kiyotaka Fujii
  • , Tooru Hanai
  • , Kouya Honda
  • , Yoshichika Horiuchi
  • , Hiroshi Inoue
  • , Kiyoo Ishige
  • , Shinichi Itoh
  • , Sachiho Iwatsuka
  • , Tomoko Kakugawa
  • , Hideto Komai
  • , Chikara Morimoto
  • , Mitsutaka Motoyoshi
  • , Masato Nakamura
  • , Mikiko Niida
  • , Ryuji Numaguchi
  • , Kiyomi Oono
  • , Hidetoshi Sakai
  • , Yasunari Sakomura
  • , Takaaki Shinohara
  • , Yuichi Takakaze
  • , Yukio Tsuruta
  • , Daigaku Uchida
  • , Norihide Ueno
  •  & Osamu Yasuda

Corresponding author

Correspondence to Chieko Kudo.

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The authors declare that they have no conflict of interest.

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UMIN-CTR: UMIN000008071.

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Kudo, C., Shin, W.S., Sasaki, N. et al. Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases: Japanese prospective multicentre observational study. Odontology 106, 316–327 (2018). https://doi.org/10.1007/s10266-017-0331-4

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