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The role of SHIP in cytokine-induced signaling

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Reviews of Physiology, Biochemistry and Pharmacology

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 149))

Abstract

The phosphatidylinositol (PI)-3 kinase (PI3K) pathway plays a central role in regulating many biological processes via the generation of the key second messenger PI-3,4,5-trisphosphate (PI-3,4,5-P3). This membrane-associated phospholipid, which is rapidly, albeit transiently, synthesized from PI-4,5-P2 by PI3K in response to a diverse array of extracellular stimuli, attracts pleckstrin homology (PH) domain-containing proteins to membranes to mediate its many effects. To ensure that the activation of this pathway is appropriately suppressed/terminated, the ubiquitously expressed tumor suppressor PTEN hydrolyzes PI-3,4,5-P3 back to PI-4,5-P2 while the 145-kDa hemopoietic-restricted SH2-containing inositol 5′-phosphatase, SHIP (also known as SHIP1), the 104-kDa stem cell-restricted SHIP (sSHIP) and the more widely expressed 150-kDa SHIP2 hydrolyze PI-3,4,5-P3 to PI-3,4-P2. In this review we will concentrate on the properties of the three SHIPs, with special emphasis being placed on the role that SHIP plays in cytokine-induced signaling.

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Abbreviations

BCR:

B cell receptor

BMMCs:

Bone marrow derived mast cells

Epo:

Erythropoietin

ES Cells:

embryonic stem cells

GM-CSF:

Granulocyte macrophage colony stimulating factor

IL-3:

Interleukin-3

IP4 :

Inositol-1,3,4,5-tetrakisphosphate

M-CSF:

Macrophage colony stimulating factor

PH:

Pleckstrin homology

PI3K:

Phosphatidylinositol-3 kinase

PI-3,4,5-P3 :

Phosphatidylinositol-3,4,5-trisphosphate

SHIP:

Src homology 2 containing inositol 5′-phosphatase

SF:

Steel Factor

sSHIP:

Stem cell SHIP

TCR:

T cell receptor

TPO:

Thrombopoietin

WT:

Wild type

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Authors and Affiliations

  1. The Terry Fox Laboratory, B.C. Cancer Agency, Vancouver, V5Z 1L3, Canada

    J. Kalesnikoff, L. M. Sly, M. R. Hughes, T. Büchse, M. J. Rauh, L.-P. Cao, V. Lam & G. Krystal

  2. The Jack Bell Research Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, Canada

    A. Mui

  3. Department of Molecular Immunology, Biology III, University of Freiburg and Max-Planck-Institute for Immunobiology, 79108, Freiburg, Germany

    M. Huber

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  1. J. Kalesnikoff
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  2. L. M. Sly
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  3. M. R. Hughes
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  4. T. Büchse
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  5. M. J. Rauh
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  6. L.-P. Cao
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  7. V. Lam
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  8. A. Mui
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  9. M. Huber
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  10. G. Krystal
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Correspondence to G. Krystal .

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© 2003 Springer-Verlag

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Kalesnikoff, J. et al. (2003). The role of SHIP in cytokine-induced signaling. In: Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology, vol 149. Springer, Berlin, Heidelberg. https://doi.org/10.1007/s10254-003-0016-y

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  • DOI: https://doi.org/10.1007/s10254-003-0016-y

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